In Vitro Fertilization in Singapore

IVF stands for in vitro fertilization. This is a highly advanced technology that helps childless couples conceive a baby successfully. This treatment is used as a treatment for both male and female infertility. During this treatment, an egg and a sperm are made to fuse in a Petri dish under laboratory conditions. The developing zygote is transferred to the womb of the mother at 8- or 16-celled stage, where further development takes place.

IVF Treatment in Singapore

In vitro fertilization in Singapore is conducted at some of the globally renowned hospitals. Thousands of infertile couples from across the world choose Singapore as their destination for IVF because of several reasons. First, the cost of treatment in the country and the cost of overall living are quite affordable. Secondly, the best hospitals for IVF treatment in Singapore are equipped with latest technology and equipment used to conduct this procedure. Moreover, this procedure is performed by a team of highly experienced and skilled IVF experts.

Treatment and Cost

60

Total Days
In Country

2 No. Travelers

1 Day in Hospital

59 Days Outside Hospital

Treatment cost starts from

USD 11200

Hospitals

About the IVF (In Vitro Fertilization)

The natural process of fertilization involves the conjugation of an egg and sperm inside the woman’s body. In-vitro-fertilization (IVF) is the procedure that involves the conception of an egg outside the body in a laboratory.  IVF comes under assisted reproductive technology (ART) that involves the use of advanced medical technology to help with pregnancy in the woman.

Which conditions may need IVF support?

  • Blocked Fallopian tubes
  • Endometriosis
  • Advanced age of a woman
  • Decreased sperm count
  • Failure of the treatment with fertility drugs

Types of IVF treatment

The different types of treatments available for IVF are:

  • Natural cycle IVF procedure: In this treatment, the fertility drugs are not administered. The egg released during the normal monthly cycle is collected and then fertilized.
  • Mild stimulation IVF procedure: The lower dose fertility drugs are administered and then the eggs are collected and fertilized.
  • In vitro maturation (IVM): The immature ovaries are collected and then allowed to mature in the laboratory.
  • Embryo transfer: The fertilized embryos are taken and transferred to the mother’s womb.
  • Blastocyst transfer: The embryos are cultured in the laboratory until blastocyst stage and then transferred to the mother’s womb.

IVF with Laser Assisted Hatching

Assisted hatching is a technique used in IVF where a gap or a hole is created on the outer shell of the embryo called zona pellucida before transferring the embryo into the mother’s womb. Before the implantation of the embryo, the developing embryo should “hatch” out of its outer shell (zona pellucida).

Sometimes the embryo is thick, which decreases its ability to hatch on its own. Making a hole or thinning the outer layer may help the embryos to hatch, which increases the chances of pregnancy. Pregnancy cannot occur unless the embryo hatches. Thus, assisted hatching IVF success rates are higher than simple IVF success rates.

Because of the use of additional technology, IVF with laser assisted hatching cost is higher than just IVF cost.

IVF with laser assisted hatching is recommended when:

  • The embryos do not have sufficient energy and nutrients to complete the hatching process
  • The woman is older than 37 years as they are more likely to have thick zona pellucida due to increased levels of follicle stimulating hormones
  • The candidate has had repeated IVF failure
  • The quality of the embryo is poor and demonstrated slow cell division and excessive fragmentation

It is performed by using infrared 1.48-μm diode laser. The technique does not cause any blastocyte damage. Laser assisted hatching has several advantages such as minimal handling of the embryo,  fast delivery, and exact control over the drilling of the hole.

It is performed before transferring the embryo into the mother’s womb on day 3, 5, or 6 after fertilization. An opening in the zona pellucida is created by drilling it with acidified tyrode’s solution.

The embryo is held firmly using holding pipette and a microneedle is applied on the area of zona pellucida. The microneedle is preloaded with Tyrode’s acid using mouth-controlled suction before each micromanipulation.

The acid is expelled over a small area of zona pellucida until it is breached. Suction is applied immediately after the breach of zona pellucida to prevent excess acid entering the embryo. The patients should be provided with antibiotics after implanting the embryo to reduce the risk of infections. 

IVF with Egg Donation

This procedure Is exactly the same as the usual IVF procedure with a difference that the egg used for fertilization comes from a different candidate than the one undergoing IVF. This procedure involves a process known as female egg donation in which a suitable candidate donates an egg for successful fertilization with the retrieved sperms.

The egg donation procedure is similar to how the eggs are retrieved from the womb of the future mother. The only difference is that during egg donation process, the ovaries of the donor are stimulated prior to the collection of suitable number of eggs from the ovaries. All the remaining stems in the donor egg IVF process are similar to the rest of the IVF procedure.

IVF with egg donation is mostly performed in the case of women who have insufficient number of eggs or whose eggs are compromised with respect to quality. The IVF specialist advices the woman to opt for donor eggs in case they believe that there are minimal chances of IVF success because of poor quality of her own eggs.

IVF with ICSI

Intracytoplasmatic sperm injection (ICSI) is an IVF variation in which the sperm is directly injected into the egg for fertilization. The resulting fertilized egg is placed in uterus of the woman. It is the most successful infertility treatment used to treat sperm-related conception problems in couples.

ICSI procedure does not require the sperm to penetrate the layers of the egg. It is highly useful to treat infertility problems in couples who suffer because the male partner’s sperms are either not able to get into the egg or are unable to fertilize the egg even when they are able to get through it.

During IVF with ICSI procedure, the eggs are extracted and held in one place with the help of a glass tool. A single sperm is injected into each egg using a small glass tube. The eggs are cultured and checked for fertilization overnight. The fully fertilized eggs are selected. A few fertilized eggs selected are placed in the uterus with the help of a catheter. The leftover embryos are preserved for future use.

While in simple IVF, the eggs and sperms are mixed together and allowed to fertilize naturally, in ICSI, a sperm is forced into the sperm for fertilization.

ICSI success rates largely depends on the quality of sperms used for fertilization. Overall, the success rate of ICSI is greater than any other technique used as a variation in the IVF procedure.

IVF with ICSI and Donor Sperms

IVF with ICSI is also performed when the sperms come from a suitable donor and not from the male partner of the female undergoing IVF procedure. ICSI IVF treatment is the same when conducted with donor sperms as it is with sperms that come from the male partner.

ICSI treatment involves the injection of a single sperm directly into the egg from the female partner or a donor. In the case of ICSI with donor sperms, a semen sample from a suitable donor is retrieved. The sperm sample is processed and viable and good quality sperms are extracted from for further procedure.

Next, the entire ICSI procedure is conducted in a similar manner. ICSI success rates are the same whether the sperm comes from a donor or the actual male partner. ICSI treatment cost is separate from the cost of IVF.

 

IVF with ICSI and Optical Spindle View

Optical spindle view is a specialized technique used at the time of IVF and ICSI. This technique helps the fertility specialists view the division of cells carefully to ensure that the entire process goes on smoothly.

The optical spindle view technique is used after the fusion of the eggs and the sperms is complete using ICSI as a part of the IVF procedure. The use of this technique helps ensure that the ICSI procedure is successful and that no DNA damage taken place around the site of injection of the sperm.

 

IVF with ICSI and Testicular Biopsy

Sometimes during IVF and ICSI, the fertility specialist may order a testicular biopsy to assess testicular function in the male partner before using his sperms. During testicular biopsy procedure, a small sample of tissue from just one or both the testicles is removed and examined under a microscope. The specialist confirms whether the male partner is fertile or not and accordingly donor sperms are arranged for IVF and ICSI.

 

How is IVF (In Vitro Fertilization) performed?

The steps through which IVF procedure occurs are:

Step 1: Over-stimulation of ovulation

Stimulation of the ovaries occurs with the administration of fertility drugs. The natural process involves the production of one egg per month, but the fertility drugs hyperstimulate the ovaries to produce more number of drugs.

Step 2: Retrieval of eggs

Removal of the eggs from the woman’s body is done through a minor surgery called follicular aspiration surgery. Pain medications are given to the woman and with the help of ultrasound, a thin needle attached to the suction pump is inserted into the vagina. The needle is directed towards the follicles containing eggs and suctions the fluid and the eggs.

Step 3: Insemination

The inactive cells from the semen are removed. The ovum and the sperms are incubated in the ratio of 1:75,000.

Step 4: Fertilization

The sperm enters the egg and fertilization takes place. If the sperm is found to be weak, then Intra-cytoplasmic sperm injection (ICSI) is performed which involves direct injection of sperm into the ovum.

Step 6: Culture of the embryo

After fertilization, the egg divides forming an embryo. The embryo rapidly divides within five days after fertilization.

Genetic diagnosis is performed after 3-4 days of fertilization to rule out the genetic disorders.

Step7: Transfer of the embryo

The embryos are transferred into the mother’s womb after 3-5 days of fertilization. This transfer is done with the help of a thin tube containing embryos. The tube is inserted through the vagina, cervix, and to the womb. Pregnancy is resulted if the embryo starts growing.

Recovery from IVF (In Vitro Fertilization)

Care to be taken after the procedure

  • You can perform your daily living activities from the next day.
  • Continue to take Progesterone pills for 8 to 12 weeks as decrease in progesterone levels may cause miscarriage.

If you have experience symptoms such as fever, pelvic pain, bleeding, and blood in urine, consult your physician immediately.

Patient Stories

Frequently Asked Questions

Why should you go for IVF in Singapore

Many couples struggling with infertility prefer to go to Singapore to get IVF treatment done. Singapore, as a medical tourism destination, is popular for its health care services and treatment facilities, and IVF is one of them.

There are many reasons why couples should choose to undergo IVF procedure in Singapore. Some of these reasons include the following:

  • Availability of all the latest assisted reproductive techniques

  • There are a number of clinics in Singapore with state-of-the-art embryology labs

  • It is highly accessible

  • The cost is comparable as compared to the Western countries such as the US

  • High standard of services and great professionalism

  • Availability of trained IVF specialists

What is the cost of IVF in Singapore

Even though IVF cost in Singapore is much more than the other popular medical tourism destinations, including Turkey, Thailand, and India, many couples still prefer to choose Singapore because of a greater sense of security and better treatment quality.

The IVF cost in Singapore starts at approximately $13000. It includes all the basic steps in an IVF cycle, including consultation, ovarian stimulation, egg retrieval, lab charges, and the cost of embryo transfer. The package does not usually including the pre-investigations conducted before the start of ovarian stimulation, the cost of medications prescribed after embryo transfer, and the expenses associated with any special technique such as intracytoplasmic sperm injection (ICSI) or the use of egg donor or sperm donor.

What are the top hospitals for IVF in Singapore

There are many clinics and hospitals that perform IVF procedure in Singapore. Some of the best IVF doctors in Singapore are associated with the JCI-certified hospitals in the country. A majority of them also have their independent clinics or may act as a visiting consultant across several hospitals.

Some of the hospitals with the best fertility doctors in Singapore include the following:

  • Mount Elizabeth Hospital

  • Mount Elizabeth Novena Hospital

  • Raffles Medical

  • Thompson Medical

  • Gleneagles Global Hospital

Is IVF in Singapore successful

IVF is a highly sensitive procedure, the success of which depends on a number of variables. It usually takes multiple cycles for couples to be able to finally conceive a baby.

The success rate of IVF in Singapore is between 40 to 60 percent. The best IVF doctors in Singapore are highly qualified, experienced, and skilled. It is recommended that one should only undergo IVF procedure in Singapore under the guidance of an experienced and qualified specialist.

However, the success of the IVF procedure depends on a number of other factors. For example, it depends on individual factors such as the quality of the egg and sperm, the health of the uterine wall for implantation, receptivity, the overall health status of the mother-to-be, and how well her body receives the embryo.

IVF is a tedious procedure that requires a lot of patience and preparation. The mother-to-be is expected to remain calm and stress-free during the entire procedure, failure of which may ultimately lead to the failure of the IVF cycle.

What is the health care infrastructure of Singapore / Why should opt for Singapore as a destination for your medical treatment?
Singapore is generally known for its well-managed health care infrastructure and has an efficient and widespread system of healthcare. Singapore was ranked 6th in the World Health Organization's ranking of the world's health systems in the year 2000. Bloomberg ranked Singapore's healthcare system the most efficient in the world in 2014. Three main healthcare groups exist in Singapore:
  • National Healthcare Group
  • National University Health System
  • SingHealth
The 10 public hospitals in Singapore comprise 8 general hospitals (AH, SGH, NUH, CGH, TTSH, KTPH, NTFGH & SKH), and 2 specialized hospitals (KKH & IMH). In addition, there are 9 national specialty centres for cancer (NCCS & NCIS), cardiac (NHCS & NUHCS), eye (SNEC), skin (NSC), neuroscience (NNI) and dental care (NDCS & NUCOHS). The private healthcare infrastructure in Singapore is also well established. The payment methods include private payment gateways or private insurance companies. You can expect better technology to be used in private hospitals in Singapore. Various procedures like stem cell therapy and cancer research are conducted in Singapore.
What are the conditions of the hospitals in Singapore? Are they JCI certified? What is the quality of the support staff in the hospitals?
The Joint Commission International (JCI) is a global leader in health care accreditation. JCI accreditation is considered a gold standard in worldwide health care. It provides the most skilled and experienced healthcare professionals in the medical industry, as evaluators of the rigorous international standards in healthcare quality and patient safety. Here are some of the JCI certified hospitals in Singapore :
  • Mount Elizabeth Hospital
  • Singapore National Eye Centre
  • National Dental Centre
  • Raffles Hospital
  • National University Hospital
  • Gleneagles Hospital
  • Singapore General Hospital
  • National Heart Centre Singapore
  • Changi General Hospital
  • National Cancer Centre
  • National Skin Centre
  • Johns Hopkins Singapore International Medical Centre
  • Tan Tock Seng Hospital
Are the doctors/surgeons in Singapore of the best quality?
Since Singapore is known all over the world for some of the best medical treatments all across the globe, you can surely expect the best quality of doctors and surgeons here. This country has a very high quality of life and hence the health of people is of high priority.
What is the process for obtaining a medical visa in India?
People who wish to go to Singapore as a tourist for social purposes or seeking medical treatment, and require a longer period of stay beyond the Visit Pass granted on entry into Singapore, may submit an application for extension of stay (not more than 89 days from date of entry) online using the e-Service of ICA. All extension applications must be submitted online using the e-service at least seven days prior to the expiry of the visit pass to avoid overstaying. Extension of visit will not be accepted over the counter. Every visit pass issued to any person as a tourist or for the purpose of a social visit or medical treatment shall be subjected to the condition that the holder shall not engage in any form of employment (paid or unpaid) or in any business, profession or occupation in Singapore during the validity of that pass unless he is a holder of a valid work pass issued under the Employment of Foreign Manpower Act. Do visit the ICA website for further information.
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Which are the best cities in Singapore for medical treatment?
Singapore is a sovereign island city in itself. So you can find many options for treatment in Singapore itself, without having to travel too much.

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