IVF stands for in vitro fertilization. This is a highly advanced technology that helps childless couples conceive a baby successfully. This treatment is used as a treatment for both male and female infertility. During this treatment, an egg and a sperm are made to fuse in a Petri dish under laboratory conditions. The developing zygote is transferred to the womb of the mother at 8- or 16-celled stage, where further development takes place.
In vitro fertilization in Singapore is conducted at some of the globally renowned hospitals. Thousands of infertile couples from across the world choose Singapore as their destination for IVF because of several reasons. First, the cost of treatment in the country and the cost of overall living are quite affordable. Secondly, the best hospitals for IVF treatment in Singapore are equipped with latest technology and equipment used to conduct this procedure. Moreover, this procedure is performed by a team of highly experienced and skilled IVF experts.
The natural process of fertilization involves the conjugation of an egg and sperm inside the woman’s body. In-vitro-fertilization (IVF) is the procedure that involves the conception of an egg outside the body in a laboratory. IVF comes under assisted reproductive technology (ART) that involves the use of advanced medical technology to help with pregnancy in the woman.
The different types of treatments available for IVF are:
Assisted hatching is a technique used in IVF where a gap or a hole is created on the outer shell of the embryo called zona pellucida before transferring the embryo into the mother’s womb. Before the implantation of the embryo, the developing embryo should “hatch” out of its outer shell (zona pellucida).
Sometimes the embryo is thick, which decreases its ability to hatch on its own. Making a hole or thinning the outer layer may help the embryos to hatch, which increases the chances of pregnancy. Pregnancy cannot occur unless the embryo hatches. Thus, assisted hatching IVF success rates are higher than simple IVF success rates.
Because of the use of additional technology, IVF with laser assisted hatching cost is higher than just IVF cost.
IVF with laser assisted hatching is recommended when:
It is performed by using
It is performed before transferring the embryo into the mother’s womb on day 3, 5, or 6 after fertilization. An opening in the zona pellucida is created by drilling it with acidified tyrode’s solution.
The embryo is held firmly using holding pipette and a microneedle is applied
The acid is expelled over a small area of zona pellucida until it is breached. Suction is applied immediately after the breach of zona pellucida to prevent excess
This procedure Is exactly the same as the usual IVF procedure with a difference that the egg used for fertilization comes from a different candidate than the one undergoing IVF. This procedure involves a process known as female egg donation in which a suitable candidate donates an egg for successful fertilization with the retrieved sperms.
The egg donation procedure is similar to how the eggs are retrieved from the womb of the future mother. The only difference is that during
IVF with egg donation is mostly performed in the case of women who have
Intracytoplasmatic sperm injection (ICSI) is an IVF variation in which the sperm is directly injected into the egg for fertilization. The resulting fertilized egg is placed in
ICSI procedure does not require the sperm to penetrate the layers of the egg. It is highly useful to treat infertility problems in couples who suffer because the male partner’s sperms are either not able to get into the egg or are unable to fertilize the egg even when they are able to get through it.
During IVF with ICSI procedure, the eggs are extracted and held in one place with the help of a glass tool. A single sperm is injected into each egg using a small glass tube. The eggs are cultured and checked for fertilization overnight. The fully fertilized eggs are selected. A few fertilized eggs selected are placed in the uterus with the help of a catheter. The leftover embryos are preserved for future use.
While in simple IVF, the eggs and sperms are mixed together and allowed to fertilize naturally, in ICSI, a sperm is forced into the sperm for fertilization.
ICSI success rates largely
IVF with ICSI is also performed when the sperms come from a suitable donor and not from the male partner of the female undergoing IVF procedure. ICSI IVF treatment is the same when conducted with donor sperms as it is with sperms that come from the male partner.
ICSI treatment involves the injection of a single sperm directly into the egg from the female partner or a donor. In the case of ICSI with donor sperms, a semen sample from a suitable donor is retrieved. The sperm sample is processed and viable and good quality sperms are extracted from for further procedure.
Next, the entire ICSI procedure is conducted in a similar manner. ICSI success rates are the same whether the sperm comes from a donor or the actual male partner. ICSI treatment cost is separate from the cost of IVF.
Optical spindle view is a specialized technique used at the time of IVF and ICSI. This technique helps the fertility specialists view the division of cells carefully to ensure that the entire process goes on smoothly.
The optical spindle view technique is used after the fusion of the eggs and the sperms
Sometimes during IVF and ICSI, the fertility specialist may order a testicular biopsy to assess testicular function in the male partner before using his sperms. During
Step 1: Over-stimulation of ovulation
Stimulation of the ovaries occurs with the administration of fertility drugs. The natural process involves the production of one egg per month, but the fertility drugs hyperstimulate the ovaries to produce more number of drugs.
Step 2: Retrieval of eggs
Removal of the eggs from the woman’s body is done through a minor surgery called follicular aspiration surgery. Pain medications are given to the woman and with the help of ultrasound, a thin needle attached to the suction pump is inserted into the vagina. The needle is directed towards the follicles containing eggs and suctions the fluid and the eggs.
Step 3: Insemination
The inactive cells from the semen are removed. The ovum and the sperms are incubated in the ratio of 1:75,000.
Step 4: Fertilization
The sperm enters the egg and fertilization takes place. If the sperm is found to be weak, then Intra-cytoplasmic sperm injection (ICSI) is performed which involves direct injection of sperm into the ovum.
Step 6: Culture of the embryo
After fertilization, the egg divides forming an embryo. The embryo rapidly divides within five days after fertilization.
Genetic diagnosis is performed after 3-4 days of fertilization to rule out the genetic disorders.
Step7: Transfer of the embryo
The embryos are transferred into the mother’s womb after 3-5 days of fertilization. This transfer is done with the help of a thin tube containing embryos. The tube is inserted through the vagina, cervix, and to the womb. Pregnancy is resulted if the embryo starts growing.
If you have experience symptoms such as fever, pelvic pain, bleeding, and blood in urine, consult your physician immediately.
Many couples struggling with infertility prefer to go to Singapore to get IVF treatment done. Singapore, as a medical tourism destination, is popular for its health care services and treatment facilities, and IVF is one of them.
There are many reasons why couples should choose to undergo IVF procedure in Singapore. Some of these reasons include the following:
Availability of all the latest assisted reproductive techniques
There are a number of clinics in Singapore with state-of-the-art embryology labs
It is highly accessible
The cost is comparable as compared to the Western countries such as the US
High standard of services and great professionalism
Availability of trained IVF specialists
Even though IVF cost in Singapore is much more than the other popular medical tourism destinations, including Turkey, Thailand, and India, many couples still prefer to choose Singapore because of a greater sense of security and better treatment quality.
The IVF cost in Singapore starts at approximately $13000. It includes all the basic steps in an IVF cycle, including consultation, ovarian stimulation, egg retrieval, lab charges, and the cost of embryo transfer. The package does not usually including the pre-investigations conducted before the start of ovarian stimulation, the cost of medications prescribed after embryo transfer, and the expenses associated with any special technique such as intracytoplasmic sperm injection (ICSI) or the use of egg donor or sperm donor.
There are many clinics and hospitals that perform IVF procedure in Singapore. Some of the best IVF doctors in Singapore are associated with the JCI-certified hospitals in the country. A majority of them also have their independent clinics or may act as a visiting consultant across several hospitals.
Some of the hospitals with the best fertility doctors in Singapore include the following:
Mount Elizabeth Hospital
Mount Elizabeth Novena Hospital
Gleneagles Global Hospital
IVF is a highly sensitive procedure, the success of which depends on a number of variables. It usually takes multiple cycles for couples to be able to finally conceive a baby.
The success rate of IVF in Singapore is between 40 to 60 percent. The best IVF doctors in Singapore are highly qualified, experienced, and skilled. It is recommended that one should only undergo IVF procedure in Singapore under the guidance of an experienced and qualified specialist.
However, the success of the IVF procedure depends on a number of other factors. For example, it depends on individual factors such as the quality of the egg and sperm, the health of the uterine wall for implantation, receptivity, the overall health status of the mother-to-be, and how well her body receives the embryo.
IVF is a tedious procedure that requires a lot of patience and preparation. The mother-to-be is expected to remain calm and stress-free during the entire procedure, failure of which may ultimately lead to the failure of the IVF cycle.
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