Best Hospitals for Bone Marrow Transplant

A bone marrow transplant is a treatment performed to replace unhealthy bone marrow with a healthy one. Bone marrow a spongy tissue inside the bone, containing the immature cells, termed as the stem cells. These stem cells can develop into:

  • Red blood cells: They help in carrying oxygen throughout the body
  • White blood cells: These help to fight infections  
  • Platelets: They assist in the clotting of blood

The bone marrow gets destroyed by infection, chemotherapy or diseases and can be treated by replacement therapy. The procedure involves transplanting bone stem cells, which then travels to the bone marrow and produce new blood cells, promoting the growth of the new marrow.

There are two types of bone marrow transplant:

  • Autologous transplant: This procedure involves the use of persons owns stem cell.
  • Allogenic transplant: This involves the use of stem cells from a donor.  

Indications for a bone marrow transplant 

A bone marrow transplant is performed in people suffering from 

  • Leukemia
  • Severe blood diseases like thalassemia, aplastic anemia, and sickle cell anemia
  • Multiple myelomas
  • Certain immune deficiency diseases
  • Inborn errors of metabolism
  • Plasma cell disorders
  • Neuroblastoma
  • Primary amyloidosis
  • POEMS syndrome
  • Bone marrow failure syndrome

Treatment and Cost

90

Total Days
In Country
  • 30 Day in Hospital
  • 2 No. Travelers
  • 60 Days Outside Hospital

Treatment cost starts from

USD 20000

62 Hospitals


Mount Elizabeth Novena Hospital located in Novena, Singapore is accredited by JCI. Also listed below are some of the most prominent infrastructural details:

  • Capacity of 333 beds
  • Intensive Care Unit beds
  • Endoscopy beds
  • Day ward with 20 beds
  • 13 Operating Theatres, which includes 1 Neurological operating room, 2 Cardiac operating rooms, 4 Orthopaedic operating rooms, etc.
  • High Dependency Unit (HDU)
  • Neonatal Intensive Care Unit (NICU)
  • 24/7 Accident & Emergency Department
  • Maternity ward
  • 1 major operating unit with 13 operating rooms inclusive of 1 hybrid theatre
  • In-house Pharmacy
  • Rooms are categorized as Single Signature Rooms, Junior Suite and Regal Suite
  • All patient rooms are equipped with electric safe, LCD, sofa cum bed, wardrobe, radio channels, and much more

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14

SPECIALITIES

6+

FACILITIES & AMENITIES


Fortis Hiranandani Hospital located in Mumbai, India is accredited by ISO, NABH. Also listed below are some of the most prominent infrastructural details:

  • The hospital has a bed capacity of 138.
  • The healthcare organisation is present on a 1, 20,000 sq. ft. area.
  • A super ICU enables healthcare delivery to critically conditions.
  • Fortis Hiranandani Hospital, Mumbai possesses world class diagnostic equipment.
  • Attractive healthcare packages are available.
  • Over 5 lakh patients have been treated till date.
  • Over 13 years of experience in healthcare delivery.
  • There are more than 38 health departments.
  • 150 plus beds are available in the hospital.
  • The hospital has many specialty areas, some of the important ones are Cardiology & Cardiac Surgery, Gastroenterology & Gastrointestinal Surgery, Gynecology & Obstetrics, Neurology & Neurosurgery etc.

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21

DOCTORS IN 13 SPECIALITIES

6+

FACILITIES & AMENITIES

USD 21320 - 27060

FOR Bone Marrow Transplant


Medicana Camlica Hospital located in Istanbul, Turkey is accredited by JCI. Also listed below are some of the most prominent infrastructural details:

  • 150 bedded Hospital
  • Specialty-based clinics
  • Fully-equipped patient rooms

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31

DOCTORS IN 14 SPECIALITIES

6+

FACILITIES & AMENITIES

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Architecture of the Hospital designed as per the comfort of patients-

  • Consisting of 8 floors, 212 bed capacity
  • 75m2 suite rooms
  • 35 thousand m2 closed area
  • 7 operating rooms
  • 53 polyclinics
  • 54 Departments
  • Hotel-like patient rooms
  • Intensive care units consisting of 33 beds
  • Hyperbaric Oxygen Center inside the hospital
  • PYXIS computerized medicine system working with fingerprint
  • Social waiting areas
  • Indoor and Outdoor Cafeterias & Restaurants

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29

DOCTORS IN 12 SPECIALITIES

6+

FACILITIES & AMENITIES


Asan Medical Centre located in Seoul, South Korea is accredited by ISO. Also listed below are some of the most prominent infrastructural details:

  • 524,700 square meters is the floor area of Asan Medical Centre
  • Number of beds is 2,715
  • 67 operating rooms
  • 11,680 outpatients
  • Everday 2,427 inpatients come to the Centre
  • 66,838 Sophisticated surgeries (per year)
  • 1,600 physicians and surgeons
  • 3,100 nurses
  • Five various types of rooms ranging from suites to multi-bed rooms

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40

DOCTORS IN 12 SPECIALITIES

5+

FACILITIES & AMENITIES


Max Smart Super Speciality Hospital located in New Delhi, India is accredited by NABH. Also listed below are some of the most prominent infrastructural details:

  • 50-bed facility with 12 high-end modular operation theatres
  • High-tech observation unit, 72 critical care beds
  • 18 HDU beds for patients
  • Dedicated endoscopy unit, and advanced dialysis units
  • Tertiary care hospital that is equipped with 256 Slice CT Angio, 3.0 Tesla digital broadband MRI,
  • Cath Lab with electrophysiology navigation, a ?at panel C-Arm detector
  • Da Vinci Xi Robotic System
  • GE Lightspeed 16-slice CT scanners
  • Interventional Radiology Suite, X-rays
  • Novalis Tx-a highly powerful radiosurgery system, which offers a combination of advanced technology for the treatment of tumours and other body parts
  • Allegretto Wave Eye-Q excimer laser, which uses technical innovations to get laser vision correction, with excellent clinical results
  • Optical Coherence Tomography
  • Bi-Plane Digital Cathlab for producing high-resolution 3D images of blood vessels in the brain
  • Offers services in medical disciplines of Cardiac Sciences, Neurology, Paediatrics, Orthopaedics, Urology, Obstetrics, and Gynaecology
  • Over 300 leading specialists, strong nursing staff, state-of-the-art innovative medical tools
  • A hub for complex procedures such as heart surgeries, orthopaedic surgeries, neurovascular intervention, targeted cancer treatments, liver & kidney transplant, and fertility treatments.
  • Interpreter Facility
  • Stay and Food Arrangement
  • Visa and Travel Arrangement
  • 3D (4D) imaging and Pure wave x Matrix technology
  • Live 3D TEE
  • 20-Inch high resolution articulating flat panel display
  • Automated Stress Echo
  • Premium Image Quality
  • Full Doppler functions

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24

DOCTORS IN 12 SPECIALITIES

6+

FACILITIES & AMENITIES

USD 22310 - 27130

FOR Bone Marrow Transplant


Apollo Hospital located in Chennai, India is accredited by JCI, NABH. Also listed below are some of the most prominent infrastructural details:

  • Committed Centers of Excellence involving many major specialties, super specialties
  • Assistance in trip planning and execution
  • Insurance related assistance
  • Visa facilitation
  • International patient representatives for complete end to end travel and transfer processing for medical travellers
  • Language translators availability
  • Robust safety and infection protocols
  • Personalised, Visa and Premium Health Checks available
  • Health Library and accessing health records online
  • Wide variety of procedures accomplished including complex and critical procedures
  • Technologically advanced systems and procedures in place
  • Research and academics base of healthcare delivery

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42

DOCTORS IN 13 SPECIALITIES

6+

FACILITIES & AMENITIES

USD 21390 - 25880

FOR Bone Marrow Transplant


BGS Gleneagles Global Hospitals located in Bengaluru, India is accredited by NABH, NABL. Also listed below are some of the most prominent infrastructural details:

  • The BGS Gleneagles Global Hospital at Kengeri has a capacity of 500 beds.
  • There are 14 operation theatres in this healthcare facility at Kengeri.
  • It is a technologically advanced hospital with imaging facilities, Transplant ICU.
  • A professionally managed International patient center caters to the huge influx of overseas patients.
  • Gleneagles Global Hospitals, Richmond Road is associated with the latest imaging services, pathology laboratory and in house pharmacy.
  • The Richmond Road hospital is a 40-bed healthcare specialty.
  • It specialises in preventive medicine options which makes regular health check ups a reality for patients.

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29

DOCTORS IN 14 SPECIALITIES

6+

FACILITIES & AMENITIES

USD 23740 - 25520

FOR Bone Marrow Transplant


Helmed by the highlyexperienced bone marrow transplant surgeons in India Indraprastha Apollo Hospital offers best bone marrow surgery at the most competitive price The hospital brings together a wealth of experience and expertise which has helped it grow as one of the top bone marrow transplant hospitals in India

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61

DOCTORS IN 14 SPECIALITIES

5+

FACILITIES & AMENITIES

USD 20010 - 25740

FOR Bone Marrow Transplant


Fortis Hospital located in Noida, India is accredited by ISO, NABH. Also listed below are some of the most prominent infrastructural details:

  • The hospital has a capacity of as many as 200 beds.
  • There are also 7 operation rooms.
  • Emergency trauma unit of the hospital is an epitome of excellence.
  • The laboratories are made to make diagnosis and analysis a strong part of the treatment process.
  • Numerous organ transplants have been performed and continued to be performed in this healthcare organization.
  • The dialysis unit of the Fortis Hospital Noida is definitely worth a mention, as is its position as a referral hospital for renal ailment treatments.
  • The critical care procedures of the hospital are a major attraction.
  • The hospital has a smoothly functioning 24/7 Emergency centre and its Cardiac Centre for Excellence is well renowned.

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32

DOCTORS IN 12 SPECIALITIES

6+

FACILITIES & AMENITIES

USD 23770 - 25730

FOR Bone Marrow Transplant


Medicana Bahcelievler Hospital located in Istanbul, Turkey is accredited by ISO, JCI. Also listed below are some of the most prominent infrastructural details:

  • Capacity of 89 beds
  • 6 Operating Rooms
  • 2 Delivery Rooms
  • Coronary Intensive Care Unit
  • General Intensive Care Unit
  • Neonatal Intensive Care Unit
  • Dialysis Unit with 30 beds

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20

DOCTORS IN 13 SPECIALITIES

6+

FACILITIES & AMENITIES


Medicana Bursa Hospital located in Bursa, Turkey is accredited by ISO, JCI. Also listed below are some of the most prominent infrastructural details:

  • Covers an indoor area of 40,000 sqm
  • 22-storey building
  • Capacity of 300 beds (100 intensive care beds and 200 single rooms)
  • Intensive care units with general intensive care units (reanimation)
  • Operating rooms are available for all kinds of surgeries
  • Cardiovascular surgery ICU
  • Neonatal ICU (NICU)
  • Coronary ICU
  • Emergency room
  • Bursa Hospital provides a 5-star hotel comfort to its patients and their relatives
  • Cinema and Conference hall with Medical explanations
  • Rest areas
  • Cafeteria
  • Game and Hobby sections for children
  • Dining room (designed for 1000 employees)
  • Terrace Rest Area

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21

DOCTORS IN 11 SPECIALITIES

6+

FACILITIES & AMENITIES


VPS Lakeshore Hospital is a leading hospital for bone marrow transplant in India. The Centre is backed by ultra-modern infrastructure and trained faculty. The hospital has formed ‘Unrelated Donor Stem Cell Transplant’ for Thalassemia Major. Their trained haematologists have performed a number of bone marrow & stem cell transplants each year. Peripheral blood stem cell transplantation has received recognition for excellent results in cancer care.

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23

DOCTORS IN 13 SPECIALITIES

6+

FACILITIES & AMENITIES


Manipal Hospital, Dwarka located in New Delhi, India is accredited by NABH. Also listed below are some of the most prominent infrastructural details:

  • 380 beds with 13 modular state-of-art OTs, 118 critical care beds, along with technological advancements like automated pneumatic chute system, telemedicine, remote monitoring, artificial intelligence, virtual reality, augmented thinking, EMR, etc.
  • 24X7 emergency and trauma services

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33

DOCTORS IN 13 SPECIALITIES

6+

FACILITIES & AMENITIES

USD 21110 - 26240

FOR Bone Marrow Transplant


Started as a small hospital and has become a large general Hospital with-

  • 254 beds
  • 12 Operating rooms
  • Staff of 1600 people including expert physicians, nurses, and auxiliary health personnel
  • Guven Medical Surgical Centre
  • IVF Centre
  • Blood Bank
  • Organ Transplant Centre
  • Fully-equipped centres to perform various types of Surgeries
  • Guven Healthy Living Campus for patients

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DOCTORS IN 14 SPECIALITIES

5+

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About the Bone Marrow Transplant

Stem cell transplant is one modern technology that is undergoing rapid improvements. It is said these days that instead of investing in various life insurance policies that are making the rounds in the market, to secure the future and precious life of your child go for stem cell technologies. This can later cure him or her from any life threatening terminal disease like cancer. Stem cell transplant has been used in recent times as a cure for cancer, but the technique is different from the stem cell bank that is maintained these days for new born.

 

Who needs a stem cell transplant?

The bone marrow which is part of the bones is responsible for making blood cells. It is soft and spongy tissue lodged inside the bone having hematopoietic stem cells. These cells either turn into bone marrow cells or can turn into any other kinds of cells or the blood cells. But there are certain forms of cancers that can keep these cells from developing normally.

A patient is recommended to get a blood as well as bone marrow stem cell transplant if they are in a condition which prevents the body from producing new healthy blood cells. Some of the conditions and diseases that prevent the bone marrow from doing so are given below:

  • Cancers like Myeloma, breast cancer, leukemia, Lymphoma may require stem cell transplant
  • Blood diseases which may require are sickle cell anemia, aplastic anemia and thalassemia
  • There are immune deficiency diseases like the congenital neutropenia, severe combined immunodeficiency syndrome, chronic granulomatous disease may demand a stem cell transplant.

The oncologist or hematologist shall decide for a stem cell transplant for a patient depending upon overall age and health, severity of the diseases and other treatment possibilities.

 

What is a stem cell transplant?

So the stem cell transplant is a kind of treatment to treat blood disorders or any types of cancer. Even blood diseases are also treated with transplants. Previously patients had to undergo a bone marrow transplant due to the fact that stem cells are collected from the bone marrow. But today stem cells get collected from the blood. And for this particular reason they are now called stem cell transplants. Nowadays stem cell therapies are used to combat hair loss and many other aesthetic related issues.

Some of the different types of stem cell treatments available are discussed below

Autologous transplant: These kinds of transplants are known as auto transplant. This kind of transplant has the scope  of very high dose chemotherapy paired with autologous stem cell rescue. In this process usually the doctors treat the cancel and then make use of the stem cells from the patient itself. From the blood, stem cells are collected and the health care team then freezes it. These cells are usually placed back in the blood after thawing them in the frozen state post the chemotherapy. The cells take almost 24 hours to reach the bone marrow and start multiplying to give rise to healthy blood cells.

Allogenic transplantation: This is better known as an allo transplant medically. In this case stem cells are obtained from another individual. But this individual needs to be someone with whom the bone marrow of the patient matches. Due to presence of proteins in white blood cells called the human leukocyte antigens (HLA) it is important that bone marrow matching takes place. The most compatible stem cell donor will have the HLA matching with that of the patient.

But the process of matching can also give rise to a very severe condition named graft versus host disease or GVHD but then it is not very likely. In this kind of a disease the healthy cells obtained from transplantation will start attacking the cells of the patients. In such cases siblings are considered to be the best match. And if they are not available then some other close family member can also work. Once the donor is fixed then the patient starts receiving chemotherapy session with or without radiotherapy. The other person’s stem is then placed in a vein via a tube. These cells unlike the previous ones are not frozen so they can be given immediately after the completion of chemotherapy.

There can be two types of Allo transplantation depending upon the age, condition and the disease that is being addressed:

The first kind is ablative where high dose of chemotherapy is used and in the second kind milder doses of chemotherapy is employed.

When the assigned health care team is unable to find a matched adult donor then are other options that must be considered like the Umbilical cord blood transplant and these days cancer centers all around the globe make use of cord blood.

Parent child transplant and haplotype mismatched transplant: In these kinds of transplants which are commonly employed the match found is 50% instead of 100% and the donor can be a parent, child or brother and sister.

How is Bone Marrow Transplant performed?

The first step in bone marrow transplant is to reduce the tumour so that the stem cell transplant success rate is improved. The process of harvesting stem cells takes around three to four hours, depending on the number of stem cells collected. The entire process may take around three to five days to complete. Blood count is daily monitored during collection of stem cells to ensure that it does not go below the admissible levels in the donor, which may contribute to anaemia.

A catheter is placed in the donor’s arm during the actual stem cell transplant procedure. The catheter is connected to a special machine that separated stem cells from the blood. After extracting the stem cells, the remaining blood is infused back into the donor's body.

 

Stem Cell Harvesting Procedure

The stem cell concentration in the bone marrow is almost 10 to 100 times more than the levels found in peripheral blood. The hip bone is considered to have the greatest amount of marrow in the active state and a large number of stem cells can also be extracted from there.

The process of harvesting the stem cells from the bone marrow is carried out in an operating room. The donor is given either general anaesthesia, an epidural, or spinal anaesthesia.

The surgeon makes a number of punctures over the skin covering the pelvic bone. A special kind of needle attached to a syringe is then inserted through these punctures. The needle penetrates the bone marrow and blood is drawn out along with marrow through the syringe. The process is continued several times to ensure enough numbers of stem cells are collected as required for the transplant. The whole duration can last for a period of one to two hours. The amount of blood and marrow removed will vary according to the weight and concentration of stem cells in the marrow of the donor. At the end of this procedure, the surgeon covers the puncture region with pressure dressing and bandages. The collected cells are filtered to separate fat particles and fragments of bones. The donor is taken to the recovery room where the hospital team checks for signs of pain, bleeding or any other side effects of the procedure. The donor can leave the hospital in a few hours after his or her body has recovered. But in some cases, they may be required to stay overnight for better monitoring.

The hip area of the donor remains sore for a few days and it is important to take medicines as directed to relieve the pain. Until the blood cell counts increase, doctors may suggest iron supplements t to enhance the ability of the bone marrow to replenish blood cells.

 

Stem Cell Transplant Procedure

High dose of chemotherapy is given to the patient immediately after stem cell collection or can even be done at a later stage. Stem cells are injected into the bloodstream of the patient after the completion of high dose chemotherapy. These stem cells travel all the way to bone marrow to start producing new blood cells, which is important as a number of healthy blood cells are lost during high dose chemotherapy.

Recovery from Bone Marrow Transplant

Until the bone marrow is in a position to make sufficient blood cells, the patient is at the risk of contracting infections and diseases. Therefore, the patient is kept in an isolation room following stem cell transplantation to protect him or her from contamination. The stay in isolation room lasts for over a week or until the level of blood cells is back to normal again.

Isolation is more important in the case of allogeneic stem cell transplant than autologous stem cell transplant. This is the reason why some hospitals do not prefer to keep a patient who has had an autologous transplant isolated.

During the recovery period, only one or two visitors are allowed to visit the patient. Those who are already ill should strictly avoid visiting the patient. There are a few hospital who conduct autologous stem cell transplant on an outpatient basis. However, the patient must come for follow-up 0vists regularly for monitoring of their health.

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