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Craniotomy Surgery Cost in Dubai

Treatment and Cost

28

Total Days
In Country
  • 5 Day in Hospital
  • 2 No. Travelers
  • 23 Days Outside Hospital

Treatment cost

USD12000 - USD50000

12 Hospitals


Types of Craniotomy in Saudi German Hospital and its associated cost

Treatment OptionApproximate Cost Range (USD)Approximate Cost Range (AED)
Overall Craniotomy Surgery15140 - 2837055626 - 105458
Extended Bifrontal Craniotomy10860 - 2779240188 - 99048
Supra-Orbital Craniotomy11690 - 2455843009 - 88814
Retro Sigmoid Craniotomy13826 - 2763950583 - 101269
Orbitozygomatic Craniotomy13353 - 2758650636 - 101439
Translabyrinthine Craniotomy13735 - 2802350599 - 104978
Pterional Craniotomy12145 - 2741644512 - 96838
Suboccipital Craniotomy12240 - 2586146333 - 92617
  • Address: Saudi German Hospital Dubai - Dubai - United Arab Emirates
  • Facilities related to Saudi German Hospital: Online Doctor Consultation, Post operative followup, Mobility Accessible Rooms, Rehabilitation, Air Ambulance

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30

DOCTORS IN 9 SPECIALITIES

20+

FACILITIES & AMENITIES

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Types of Craniotomy in Aster DM Healthcare and its associated cost

Treatment OptionApproximate Cost Range (USD)Approximate Cost Range (AED)
Overall Craniotomy Surgery15127 - 2779956170 - 103286
Extended Bifrontal Craniotomy11144 - 2706240233 - 100718
Supra-Orbital Craniotomy11387 - 2465942602 - 90874
Retro Sigmoid Craniotomy13847 - 2736950037 - 99188
Orbitozygomatic Craniotomy13406 - 2706149269 - 98464
Translabyrinthine Craniotomy13780 - 2845050000 - 105849
Pterional Craniotomy12489 - 2651945866 - 96849
Suboccipital Craniotomy12384 - 2509646211 - 91886
  • Address: Aster DM Healthcare - Dubai - United Arab Emirates
  • Facilities related to Aster DM Healthcare: Choice of Meals, Interpreter, SIM, TV inside room, Accommodation

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28

DOCTORS IN 10 SPECIALITIES

6+

FACILITIES & AMENITIES


Types of Craniotomy in NMC Specialty Hospital, Al Nahda and its associated cost

Treatment OptionApproximate Cost Range (USD)Approximate Cost Range (AED)
Overall Craniotomy Surgery15349 - 2842355640 - 101982
Extended Bifrontal Craniotomy11071 - 2685240621 - 100963
Supra-Orbital Craniotomy11694 - 2492042160 - 88845
Retro Sigmoid Craniotomy13464 - 2778450003 - 98379
Orbitozygomatic Craniotomy13461 - 2756750070 - 98983
Translabyrinthine Craniotomy13313 - 2882150112 - 104246
Pterional Craniotomy12398 - 2658045226 - 98647
Suboccipital Craniotomy12199 - 2493546352 - 93091
  • Address: NMC Speciality Hospital Al Nahda Dubai - Dubai - United Arab Emirates
  • Facilities related to NMC Specialty Hospital, Al Nahda: Choice of Meals, Interpreter, SIM, TV inside room, Accommodation

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46

DOCTORS IN 10 SPECIALITIES

6+

FACILITIES & AMENITIES

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Types of Craniotomy in Zulekha Hospital Dubai and its associated cost

Treatment OptionApproximate Cost Range (USD)Approximate Cost Range (AED)
Overall Craniotomy Surgery15425 - 2870656346 - 102603
Extended Bifrontal Craniotomy10721 - 2781339598 - 98383
Supra-Orbital Craniotomy11542 - 2430441750 - 91089
Retro Sigmoid Craniotomy13721 - 2730850486 - 101049
Orbitozygomatic Craniotomy13459 - 2779050799 - 98613
Translabyrinthine Craniotomy13381 - 2861049841 - 105383
Pterional Craniotomy12423 - 2634244412 - 100853
Suboccipital Craniotomy12471 - 2500145638 - 95171
  • Address: Zulekha Hospital Dubai - Dubai - United Arab Emirates
  • Facilities related to Zulekha Hospital Dubai: Choice of Meals, Interpreter, SIM, TV inside room, Accommodation

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13

DOCTORS IN 10 SPECIALITIES

6+

FACILITIES & AMENITIES


Types of Craniotomy in Prime Hospital and its associated cost

Treatment OptionApproximate Cost Range (USD)Approximate Cost Range (AED)
Overall Craniotomy Surgery15031 - 2773756263 - 106132
Extended Bifrontal Craniotomy10687 - 2723240604 - 100516
Supra-Orbital Craniotomy11543 - 2398942629 - 89043
Retro Sigmoid Craniotomy13544 - 2665450437 - 100508
Orbitozygomatic Craniotomy13884 - 2679950607 - 101327
Translabyrinthine Craniotomy13820 - 2831248929 - 104010
Pterional Craniotomy12161 - 2742344534 - 98491
Suboccipital Craniotomy12333 - 2580446174 - 92732
  • Address: Prime Hospital - Dubai - United Arab Emirates
  • Facilities related to Prime Hospital: Online Doctor Consultation, Post operative followup, Mobility Accessible Rooms, Rehabilitation, Air Ambulance

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16

DOCTORS IN 9 SPECIALITIES

20+

FACILITIES & AMENITIES


Types of Craniotomy in Burjeel Hospital for Advanced Surgery Dubai and its associated cost

Treatment OptionApproximate Cost Range (USD)Approximate Cost Range (AED)
Overall Craniotomy Surgery15461 - 2838356949 - 106218
Extended Bifrontal Craniotomy10957 - 2765239659 - 99991
Supra-Orbital Craniotomy11609 - 2473242073 - 90183
Retro Sigmoid Craniotomy13426 - 2673750429 - 99821
Orbitozygomatic Craniotomy13346 - 2689849526 - 98549
Translabyrinthine Craniotomy13365 - 2882250132 - 106363
Pterional Craniotomy12281 - 2693845422 - 97505
Suboccipital Craniotomy12481 - 2538245639 - 92433
  • Address: Burjeel Hospital for Advanced Surgery Dubai - Sheikh Zayed Road - Dubai - United Arab Emirates
  • Facilities related to Burjeel Hospital for Advanced Surgery Dubai: Online Doctor Consultation, Post operative followup, Mobility Accessible Rooms, Rehabilitation, Air Ambulance

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9

DOCTORS IN 7 SPECIALITIES

20+

FACILITIES & AMENITIES


Types of Craniotomy in Iranian Hospital and its associated cost

Treatment OptionApproximate Cost Range (USD)Approximate Cost Range (AED)
Overall Craniotomy Surgery15100 - 2848254874 - 105977
Extended Bifrontal Craniotomy10852 - 2770239998 - 101991
Supra-Orbital Craniotomy11684 - 2412842364 - 91127
Retro Sigmoid Craniotomy13846 - 2737650050 - 98361
Orbitozygomatic Craniotomy13702 - 2678549282 - 100573
Translabyrinthine Craniotomy13848 - 2821949625 - 105196
Pterional Craniotomy12557 - 2731546424 - 98430
Suboccipital Craniotomy12123 - 2504645191 - 93352
  • Address: Iranian Hospital - Al Wasl Road - Dubai - United Arab Emirates
  • Facilities related to Iranian Hospital: SIM, TV inside room, Airport Transfer, Choice of Meals

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9

DOCTORS IN 11 SPECIALITIES

4+

FACILITIES & AMENITIES


Types of Craniotomy in Kings College Hospital Dubai and its associated cost

Treatment OptionApproximate Cost Range (USD)Approximate Cost Range (AED)
Overall Craniotomy Surgery15421 - 2810356795 - 104188
Extended Bifrontal Craniotomy11125 - 2702240030 - 99335
Supra-Orbital Craniotomy11489 - 2460743018 - 89123
Retro Sigmoid Craniotomy13332 - 2662350881 - 101276
Orbitozygomatic Craniotomy13637 - 2779649480 - 101021
Translabyrinthine Craniotomy13592 - 2904349283 - 105768
Pterional Craniotomy12455 - 2698045106 - 96498
Suboccipital Craniotomy12398 - 2564745070 - 93989
  • Address: King's College Hospital London, Dubai, East Exit - Al Marabea' Street - Dubai - United Arab Emirates
  • Facilities related to Kings College Hospital Dubai: Choice of Meals, Interpreter, SIM, TV inside room, Accommodation

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25

DOCTORS IN 11 SPECIALITIES

6+

FACILITIES & AMENITIES


The Neuro Spinal Hospital is located in Dubai Science Park in Dubai. It is a pioneer in bringing the latest Technology, Medicine, and Education to heal and serve the community. It has been approved and accredited by the Dubai Health Authority and has the Government of Dubai and Dubai Health Experience as its partners.

It has a 114-bed capacity, green spaces for the rehabilitation of the patients, and smart patient rooms, and is four times that of its former premises in terms of capacity. It is also the first hospital to have surgical robots in UAE. The Continous Medical Education (CME) program was introduced in 2007 by the hospital that has become a mandatory requirement for all healthcare professionals. Practitioners need to provide that they have attended enough CME hours to be promoted to a higher level or renew their licenses.

The hospital consists of multinational staff who are dedicated to working together for solving problems with the patients and their families, to provide the highest level of support and care through advanced and progressive technologies, and an evidence approach to medicine, all delivered in a collaborative and compassionate environment. The team believes in safety, quality, dignity, engagement, and collaboration in providing premium healthcare to the patient.  It consists of specialized units such as spinal and back pain units, joint replacement centers, sports medicine, orthopedics, oncology, neurology, physiotherapy, etc.


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5

SPECIALITIES

10+

FACILITIES & AMENITIES


Types of Craniotomy in Canadian Specialist Hospital and its associated cost

Treatment OptionApproximate Cost Range (USD)Approximate Cost Range (AED)
Overall Craniotomy Surgery15484 - 2810756876 - 102873
Extended Bifrontal Craniotomy10829 - 2738939976 - 99051
Supra-Orbital Craniotomy11567 - 2461243409 - 90180
Retro Sigmoid Craniotomy13519 - 2686049527 - 102078
Orbitozygomatic Craniotomy13707 - 2767449642 - 99522
Translabyrinthine Craniotomy13449 - 2850750891 - 102979
Pterional Craniotomy12551 - 2670246265 - 100409
Suboccipital Craniotomy12534 - 2530045663 - 94632
  • Address: Canadian Specialist Hospital - Dubai - United Arab Emirates
  • Facilities related to Canadian Specialist Hospital: Choice of Meals, Interpreter, SIM, TV inside room, Accommodation

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21

DOCTORS IN 9 SPECIALITIES

6+

FACILITIES & AMENITIES


Types of Craniotomy in NMC Royal Hospital, DIP and its associated cost

Treatment OptionApproximate Cost Range (USD)Approximate Cost Range (AED)
Overall Craniotomy Surgery15310 - 2775355899 - 105065
Extended Bifrontal Craniotomy11036 - 2773840471 - 99711
Supra-Orbital Craniotomy11568 - 2434843450 - 90510
Retro Sigmoid Craniotomy13788 - 2729650465 - 98429
Orbitozygomatic Craniotomy13806 - 2700750432 - 99312
Translabyrinthine Craniotomy13564 - 2814849144 - 103978
Pterional Craniotomy12511 - 2674445771 - 99561
Suboccipital Craniotomy12238 - 2556645318 - 93801
  • Address: NMC Hospital, DIP - Dubai - United Arab Emirates
  • Facilities related to NMC Royal Hospital, DIP: Online Doctor Consultation, Post operative followup, Mobility Accessible Rooms, Rehabilitation, Air Ambulance

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23

DOCTORS IN 9 SPECIALITIES

20+

FACILITIES & AMENITIES


Types of Craniotomy in Medeor 24X7 Hospital and its associated cost

Treatment OptionApproximate Cost Range (USD)Approximate Cost Range (AED)
Overall Craniotomy Surgery13667 - 2570150416 - 93780
Extended Bifrontal Craniotomy9863 - 2448835955 - 90060
Supra-Orbital Craniotomy10430 - 2215038358 - 81527
Retro Sigmoid Craniotomy12275 - 2451845173 - 90418
Orbitozygomatic Craniotomy12281 - 2464645082 - 90173
Translabyrinthine Craniotomy12333 - 2571945031 - 93788
Pterional Craniotomy11120 - 2419041057 - 88737
Suboccipital Craniotomy11164 - 2282741099 - 84547
  • Address: Medeor 24x7 Hospital - Dubai - United Arab Emirates
  • Facilities related to Medeor 24X7 Hospital: Choice of Meals, Interpreter, SIM, TV inside room, Accommodation

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21

DOCTORS IN 9 SPECIALITIES

6+

FACILITIES & AMENITIES

Other Related Hospitals


Types of Craniotomy in Zulekha Hospital Sharjah and its associated cost

Treatment OptionApproximate Cost Range (USD)Approximate Cost Range (AED)
Overall Craniotomy Surgery15091 - 2864556626 - 102381
Extended Bifrontal Craniotomy11093 - 2728639272 - 101823
Supra-Orbital Craniotomy11828 - 2460842422 - 89575
Retro Sigmoid Craniotomy13546 - 2701048994 - 97772
Orbitozygomatic Craniotomy13439 - 2693150769 - 98755
Translabyrinthine Craniotomy13784 - 2807750166 - 103627
Pterional Craniotomy12280 - 2686045411 - 97895
Suboccipital Craniotomy12546 - 2502044467 - 91563
  • Address: Zulekha Hospital - Sharjah - United Arab Emirates
  • Facilities related to Zulekha Hospital Sharjah: Choice of Meals, Interpreter, SIM, TV inside room, Accommodation

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11

DOCTORS IN 10 SPECIALITIES

6+

FACILITIES & AMENITIES


Types of Craniotomy in NMC Royal Hospital, Khalifa City and its associated cost

Treatment OptionApproximate Cost Range (USD)Approximate Cost Range (AED)
Overall Craniotomy Surgery15428 - 2842455378 - 105496
Extended Bifrontal Craniotomy10847 - 2762439439 - 98433
Supra-Orbital Craniotomy11663 - 2403343199 - 89821
Retro Sigmoid Craniotomy13375 - 2739649460 - 99232
Orbitozygomatic Craniotomy13865 - 2737450810 - 98898
Translabyrinthine Craniotomy13875 - 2895049482 - 104820
Pterional Craniotomy12105 - 2686944893 - 97920
Suboccipital Craniotomy12496 - 2557245537 - 94282
  • Address: NMC Royal Hospital Khalifa City - Abu Dhabi - United Arab Emirates
  • Facilities related to NMC Royal Hospital, Khalifa City: Online Doctor Consultation, Post operative followup, Mobility Accessible Rooms, Rehabilitation, Air Ambulance

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36

DOCTORS IN 11 SPECIALITIES

20+

FACILITIES & AMENITIES


Types of Craniotomy in NMC Royal Hospital Sharjah and its associated cost

Treatment OptionApproximate Cost Range (USD)Approximate Cost Range (AED)
Overall Craniotomy Surgery15024 - 2797756795 - 102496
Extended Bifrontal Craniotomy10691 - 2730540172 - 98914
Supra-Orbital Craniotomy11832 - 2408042401 - 89524
Retro Sigmoid Craniotomy13667 - 2670949797 - 101441
Orbitozygomatic Craniotomy13567 - 2675649270 - 101334
Translabyrinthine Craniotomy13750 - 2813148891 - 102408
Pterional Craniotomy12500 - 2680445165 - 100746
Suboccipital Craniotomy12155 - 2501545149 - 94277
  • Address: NMC Royal Hospital Sharjah - Sharjah - United Arab Emirates
  • Facilities related to NMC Royal Hospital Sharjah: Online Doctor Consultation, Post operative followup, Mobility Accessible Rooms, Rehabilitation, Air Ambulance

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64

DOCTORS IN 11 SPECIALITIES

20+

FACILITIES & AMENITIES

About the Craniotomy

Craniotomy surgery is one of the most common types of brain surgery conducted to treat a brain tumor. It mainly aims at removing a lesion, tumor, or a blood clot in the brain by opening a flap above the brain to access the targeted area. This flap is removed on a temporary basis and again put in place when the surgery is done. Around 90 percent of the cases of brain tumors are diagnosed in adults aged between 55 and 65. Among children, a brain tumor is diagnosed within an age range of 3 to 12 years.

Craniotomy procedures are conducted with the help of magnetic resonance imaging (MRI) scans to reach the location precisely in the brain that requires treatment. A three-dimensional image for the same is achieved of the brain in conjunction with localizing frames and computers to view a tumor properly. A clear distinction is made between abnormal or tumor tissue and normal healthy tissue and to access the exact location of the abnormal tissue.

Who requires a craniotomy?

In a minimally invasive craniotomy procedure, a burr hole or a keyhole may be created to access the brain to fulfill the following purposes:

  • To drain out cerebrospinal fluid in case of hydrocephalus by inserting a shunt into the ventricles
  • To treat Parkinson’s disease by inserting a deep brain stimulator (DBS)
  • To insert an intracranial pressure monitor
  • To conduct needle biopsy, where a small sample of abnormal tissue is removed for study
  • For stereotactic hematoma aspiration, in which a blood clot is drained out
  • For insertion of an endoscope to clip aneurysms and for the removal of small tumors

When there are complex craniotomies involved, the procedure may be referred to as a skull base surgery.  In this kind of surgery, a small portion of the skull is removed from the bottom of the brain. This is the region where delicate arteries, veins, and cranial nerves exit the skull. Complicated planning is done to plan such craniotomies and understand the location of the lesions. This type of approach is usually employed for:

  • The removal or treatment of large brain tumors and aneurysm in the brain
  • Treatment after a skull fracture or major injury like a gunshot
  • The removal of a malignant tumor affecting the bony skull

Primary brain tumors are much less common than secondary brain tumors. Primary ones are found to originate very close to the brain itself or in the tissues very close to it, such as the covering membranes of the brain, including the meninges, cranial nerves, pineal, or pituitary gland. It begins with normal cells, which at a later period undergoes some mutational errors in their DNA. The mutation triggers cells to grow and divide at a very high rate while healthy cells keep dying around it. This results in a mass of abnormal cells which gives rise to a tumor. Unlike primary tumors, the secondary tumors begin as cancer elsewhere and spread to the brain.

Symptoms of brain tumor

  • Different patterns of a headache
  • Headaches get more frequent and acutely painful
  • Nausea
  • Blurred vision, double vision, or loss of peripheral vision
  • Loss of sensation in the arm or any leg gradually
  • Balance difficulty
  • Speech problems with confusion in simple matters
  • Hearing problems
  • Personality change
  • Sudden seizures and attacks or bouts of pain

Types of Craniotomy

No matter what the goal of the surgery is, it is best to ensure that the incision is made to address the intracranial lesion keeping some principles in mind. A wide variety of intracranial processes can be done via a craniotomy with a different variety of incisions. Some of these variations include frontal craniotomy, pterional craniotomy, temporal craniotomy, decompression craniectomy, and suboccipital craniotomy.

How is Craniotomy performed?

  • An intravenous line is first placed in the arm and general anaesthesia is employed while the patient lies on the operating table.
  • When the patient is no more awake, the head is placed in a 3-pin skull fixing the device. This is attached to a table and keeps the head in a fixed position all throughout the procedure.
  • An insertion of a lumbar drain is made in the lower back to drain out the cerebrospinal fluid. A relaxation drug for the brain named mannitol can be administered at this stage.
  • With an antiseptic, the skull is prepared and an incision is made usually behind the hairline. A good cosmetic result is achieved after the surgery and a hair sparing technique, which requires shaving only one-fourth inch-wide area along the incision proposed is aimed. At times, the total area of the incision may be shaved.
  • The skin and muscles are then removed from the bone and folded back, burr holes are made in the skull using a drill.
  • A saw is introduced through the holes made and cuts the bone flap’s outline. The protective covering of the brain named dura is exposed after the craniotome (the saw) removes the bone flap. This bone flap is kept aside securely to be attached back again after the surgery.
  • Once the dura is opened with surgical scissors, the surgeon folds it back to access the brain. There are retractors placed on the brain to have a corridor opened gently in the brain to address the region requiring removal or repair. 
  • Loupes are used by neurosurgeons, which are special magnifying glasses or an operating microscope to get a view of the delicate nerves and vessels.
  • The brain is very tightly enclosed within the skull and hence, removal of tissues cannot be done easily to repair problems.
  • Therefore, a variety of tools and instruments are employed to work in the deep circuits of the brain like drills, lasers, ultrasonic aspirators (used to break tumours and have the pieces suctioned), dissectors, long handled scissors, and of course computer-aided guidance.
  • Evoked potential monitoring may also be employed to stimulate the specific cranial nerves and the responses generated are monitored. This step ensures that the nerves are functioning properly and not getting damaged as a result of the surgery.
  • After the problem is rectified, the retractors are released and dura is closed along with sutures and the bone flap is placed in its original position and secured with titanium screws and plates. These screws and plates remain permanently in place to support the region and can be felt under the skin.
  • A drain can also be kept as is for some time. It helps collect blood and fluids from the area that is subjected to the surgery. T
  • he skin and muscles are sutured together and a soft turban-like adhesive is placed as dressing over the incision.

Recovery from Craniotomy

  • The patient is shifted to a recovery room where vital signs are monitored after he or she is in complete senses and the effect of the anaesthesia completely wears off.
  • Drowsiness, nausea, and headache are common in craniotomy recovery surgery. Hands, fingers, and toes must be moved frequently to avoid the formation of blood clots.
  • Anticonvulsant medications may be provided and a nurse may keep asking simple questions to figure out alertness.
  • Hospital stay varies from two to three days or even two weeks, depending on the complications that may result.
  • After discharge, keep away from strenuous activities. Some exercises may be prescribed for the slow movement of head and neck.
  • You should notify your doctor about any increase in temperature or infection observed at the sites of the incision. Bathing instructions should be strictly followed.
  • It almost takes around two to eight weeks for complete recovery. Keep visiting your doctor for follow-up checkup or as instructed. Contact your doctor immediately in case of loss of mental function, stroke, seizure, or nerve damage.

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Frequently Asked Questions

What are the factors affecting the cost of Craniotomy in Dubai?

Different hospitals have different pricing policy when it comes to the cost of Craniotomy in Dubai. The top hospitals for Craniotomy in Dubai covers all the expenses related to the pre-surgery investigations of the candidate. The Craniotomy package in Dubai includes the fees of the surgeon, hospitalization and anesthesia as well. Extended hospital stay, complications after the surgery or new diagnosis may affect the overall cost of Craniotomy in Dubai.

Which are some of the best hospitals in Dubai for Craniotomy
How many days does it take to recover post Craniotomy in Dubai

Upon discharge from the hospital after Craniotomy in Dubai, the patients are advised to stay for about 23 days for recovery. This duration of stay is recommended to complete all the necessary follow-ups and control tests to ensure that the surgery was successful.

Which are some of the other popular destinations for Craniotomy

While Dubai is considered to be one of the best destinations for Craniotomy owing to the standard of Hospitals, and expertise of doctors Some of the other destinations that are popular for Craniotomy include the following:

How much are the other expenses in Dubai apart from the cost of Craniotomy

Apart from the Craniotomy cost, the patient may have to pay for additional daily expenses such as for guest house after discharge and meals. These are the chanrges for daily meals and hotel stay outside the hospital. The extra charges may vary from 60 USD.

Which are the best doctors offering Telemedicine for Craniotomyation in Dubai

Patients who are interested in availing telemedicine consultation before they travel for Craniotomy in Dubai can opt for the same. Some of the surgeons offering this service include the following:

Some of the most sought after doctors available for online video consultation for Craniotomy in Dubai are:

Doctor NameCostBook Appointment
Dr. Srinivas Janga182Book Now
Dr. Pawan Kashyape150Book Now
Dr. Preeti Sahota182Book Now
Dr. Sushil Garg182Book Now
Dr. Mohamed Ismail182Book Now
Dr. Santosh Sharma230Book Now
How many days does one have to spend in the hospital for Craniotomy in Dubai?

The patient has to spend about 5 Days in the hospital after Craniotomy for proper recovery and to get clearance for discharge. The patient is subjected to several biochemistry and radiological scans to see that everything is okay and the recovery is on track. After making sure that patient is clinically stable, discharge is planned.

What is the average rating of Hospitals in Dubai?

Hospitals offering Craniotomy in Dubai are rated 3.8 on an average. The average rating is based on several parameters such as cleanliness, fair pricing, and quality of care.

How many hospitals offer Craniotomy in Dubai?

There are about 12 Hospitals in Dubai that offer Craniotomy to international patients. These hospitals are approved to perform the surgery and have proper infrastructure to handle Craniotomy patients. Additionally, these hospitals are known to comply with the international standards as well as local legal requirements for the treatment of patients.