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Castleman disease is a group of rare disorders characterized by enlarged lymph nodes and a wide range of symptoms. The most common form of the disorder involves a single enlarged lymph node, typically found in the chest or neck, but it can occur in other areas of the body as well. This form is known as Unicentric Castleman Disease (UCD).

Multicentric Castleman Disease (MCD), on the other hand, involves multiple regions of enlarged lymph nodes, along with inflammatory symptoms and problems with organ function.

The goals of treating Castleman's illness are to reduce inflammation, alleviate symptoms, control aberrant lymph node cell growth, and avoid significant side effects, including cancer or infections. Whether the disease is widespread (Multicentric Castleman Disease, or MCD) or limited (Unicentric Castleman Disease, or UCD), the objective is to control it and enhance quality of life.

Consult a physician if you have fever, night sweats, enlarged organs, unexplained weight loss, swollen lymph nodes, or chronic exhaustion. MediGence's team of professionals can help you get an accurate diagnosis and a condition-specific care plan.

Preparation includes blood testing, imaging (CT, PET, or MRI scans), and lymph node biopsy to determine the disease subtype (ucd, HHV-8-associated MCD, or idiopathic MCD). Consult your doctor about all of your current medications and medical history. In multicentric instances, further HIV and HHV-8 screening might be necessary.

Surgical Removal: The afflicted lymph node is usually removed during surgery for UCD.
Medications: Corticosteroids, immunotherapy, antiviral medications (if HHV-8 positive), or chemotherapy are some of the medicines used to treat MCD.
Supportive Care: Monitoring organ function, preventing infections, and managing discomfort are all included in supportive care.
Follow-up: Continuous assessment using imaging and labs to evaluate response and modify therapy.

Surgical removal in UCD may require a brief hospital stay and a few weeks of recovery. Treatment for MCD involves continuous medication or therapy for several months under close observation. The length of treatment varies according to the severity and response of the disease.

There are no known risk factors for Unicentric Castleman Disease (UCD) or Idiopathic Multicentric Castleman Disease (iMCD), but individuals with HIV or weakened immune systems are at higher risk for Human Herpesvirus 8 (HHV-8) associated Multicentric Castleman Disease (MCD). In rare instances, Castleman disease can result in paraneoplastic pemphigus (PNP) in UCD patients and raise the risk of malignancies like lymphoma. Additionally, MCD may increase the risk of serious infections, which, if left untreated, can result in potentially fatal organ damage.

With timely and focused treatment, effective symptom management, lymph node reduction, prevention of complications, and general quality of life can all be achieved. While continuous therapy aids in maintaining disease control and stability in MCD, surgery frequently leads to a full recovery in Unicentric Castleman Disease.

Following UCD surgery, recovery includes wound care and pain management, along with follow-up to make sure there is no recurrence. Patients with MCD may require ongoing care and routine monitoring for immune system activity, infections, and medication response.

Surgical treatment for UCD has a high success rate and is often curative. Modern treatments for MCD, such as monoclonal antibodies, have greatly enhanced results and provided efficient long-term disease management.

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Explore Hospitals ( 3 )

Metro Hospital

Noida, India

Metro Hospital located in Noida, India is accredited by ISO, NABH, NABL. Also listed below are some of the most prominent infrastructural details:

Metro Hospital is a 317 bedded state-of-the-art super speciality hospital, which is functioning as two units- 110 beds capacity in Metro Heart Institute and 207 beds capacity in Metro Multispeciality Hospital
45 beds in Intensive Coronary Care and High Dependency Unit
24/7 Blood Bank
24/7 Pharmacy
24/7 Cardiac Ambulance
24/7 Emergency unit
Different types of patients in-patient rooms are available for patients convenience- Super Deluxe rooms (8), Deluxe Rooms (2), Private Rooms (6), Semi-private rooms (14), Triple bedded rooms (6), Four bedded rooms (8), Five bedded rooms (5) and Six bedded rooms (12)
Cafeteria/Restaurant

34

DOCTORS IN 12 SPECIALITIES

15+

FACILITIES & AMENITIES

Price On Request

Fortis Hospital

Noida, India

3.0 ( 1 Reviews )

Fortis Healthcare Limited is one of India’s prominent providers of integrated healthcare services, offering comprehensive medical care across multiple specialities. The company’s operations span hospitals, diagnostic centres, and day-care speciality facilities, ensuring a wide range of healthcare solutions under one umbrella. Fortis has established a strong presence across the country, managing 33 healthcare facilities, which include joint ventures and operational & management (O&M) setups, across 11 states.

The company’s hospital network comprises more than 5,700 operational beds, including O&M beds, catering to patients with varied healthcare needs. In addition to inpatient services, Fortis operates around 400 diagnostic laboratories, providing reliable and timely diagnostic support for accurate medical care. This extensive network enables Fortis to deliver high-quality healthcare services consistently and efficiently, from routine diagnostics to specialised treatments and complex procedures.

31

DOCTORS IN 12 SPECIALITIES

19+

FACILITIES & AMENITIES

Price On Request

Jaypee Hospital

Noida, India

Jaypee Hospital located in Noida, India is accredited by ISO, NABH, NABL. Also listed below are some of the most prominent infrastructural details:

525 beds in the first phase
150 Critical Care beds
325 ward beds with Suite, Deluxe, Twin Sharing, and Economy options
18 Modular OTs
4 Cardiac Catheterization Lab with unqie Hybrid Operating Room
24 bedded Advanced Neonatal ICUs20 bedded Dialysis Units
2 Linear Accelerator (IMRT, VMAT, I
GRT), Wide Bore CT Simulator, one Brachytherapy Suite
True Beam STx Linear Accelerator
2 MRI (3.0 Tesla) with High-Intensity Focused Ultrasound
64 Slice PET CT, Gamma Camera, Dual Head 6 Slice SPECT CT
256 Slice CT Scan, CT Simulation
Amongst the few GOLD LEED-certified hospital buildings in India
Appointment Scheduling
Flow motion 64 Slice PET CT technology
Pick and drop facility from/to the Airport
Foreign exchange facility
Treatment packages
Visa assistance
Admission in the hospital
Wi-Fi/internet service in the room
Travel arrangement for patient & attendant after discharge
Tele-consults after discharge
Dedicated Guest House for International Patients maintained by Jaypee Hospital
In-house translators for patient’s comfort
Assistance in getting doctor’s opinion
Registration with the Foreigners Regional Registration Office
Accommodation arrangements after discharge
Accommodation arrangement for the accompanying attendant
Customized diet for patient and attendant
Laundry services
Prayer room
Dialysis facility for 60 patients
Cadaver organs
Blood bank facilities
Advanced Laboratory facilities
Diagnostic and Radiology facilities
High-end Ultrasound facilities

28

DOCTORS IN 14 SPECIALITIES

19+

FACILITIES & AMENITIES

Price On Request

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Author

Nimra Haseeb

MSc Biochemistry

4 Years of Experience

Miss Nimra Haseeb is a medical researcher and a scientific content writer. She holds a Bachelor’s degree in Biotechnology and a Master’s in Biochemistry from Integral University, Lucknow.With strong experience in healthcare research, she specializes in secondary research, clinical data analysis, and evidence-based medical writing. Her work focuses on transforming complex scientific and medical information into clear, accurate, and reliable healthcare content for patients and healthcare audiences. She is also experienced in interpreting medical studies and healthcare trends to deliver well-researched and informative content that supports better health awareness and decision-making.. View More

Reviewer

Dr Prateek Varshney

Surgical Oncologist

15 Years of Experience

Dr. Prateek Varshney is a renowned Surgical Oncologist. He has experience of more than 15+ years in surgical Oncology. He is currently practicing as a consultant at Metro Mass Hospital and Cancer Institute. He was also previously associated as a consultant with Sir Ganga Ram Hospital and as a professor at Gujarat Cancer Research Institute. View More

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