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Castleman disease is a group of rare disorders characterized by enlarged lymph nodes and a wide range of symptoms. The most common form of the disorder involves a single enlarged lymph node, typically found in the chest or neck, but it can occur in other areas of the body as well. This form is known as Unicentric Castleman Disease (UCD).

Multicentric Castleman Disease (MCD), on the other hand, involves multiple regions of enlarged lymph nodes, along with inflammatory symptoms and problems with organ function.

The goals of treating Castleman's illness are to reduce inflammation, alleviate symptoms, control aberrant lymph node cell growth, and avoid significant side effects, including cancer or infections. Whether the disease is widespread (Multicentric Castleman Disease, or MCD) or limited (Unicentric Castleman Disease, or UCD), the objective is to control it and enhance quality of life.

Consult a physician if you have fever, night sweats, enlarged organs, unexplained weight loss, swollen lymph nodes, or chronic exhaustion. MediGence's team of professionals can help you get an accurate diagnosis and a condition-specific care plan.

Preparation includes blood testing, imaging (CT, PET, or MRI scans), and lymph node biopsy to determine the disease subtype (ucd, HHV-8-associated MCD, or idiopathic MCD). Consult your doctor about all of your current medications and medical history. In multicentric instances, further HIV and HHV-8 screening might be necessary.

Surgical Removal: The afflicted lymph node is usually removed during surgery for UCD.
Medications: Corticosteroids, immunotherapy, antiviral medications (if HHV-8 positive), or chemotherapy are some of the medicines used to treat MCD.
Supportive Care: Monitoring organ function, preventing infections, and managing discomfort are all included in supportive care.
Follow-up: Continuous assessment using imaging and labs to evaluate response and modify therapy.

Surgical removal in UCD may require a brief hospital stay and a few weeks of recovery. Treatment for MCD involves continuous medication or therapy for several months under close observation. The length of treatment varies according to the severity and response of the disease.

There are no known risk factors for Unicentric Castleman Disease (UCD) or Idiopathic Multicentric Castleman Disease (iMCD), but individuals with HIV or weakened immune systems are at higher risk for Human Herpesvirus 8 (HHV-8) associated Multicentric Castleman Disease (MCD). In rare instances, Castleman disease can result in paraneoplastic pemphigus (PNP) in UCD patients and raise the risk of malignancies like lymphoma. Additionally, MCD may increase the risk of serious infections, which, if left untreated, can result in potentially fatal organ damage.

With timely and focused treatment, effective symptom management, lymph node reduction, prevention of complications, and general quality of life can all be achieved. While continuous therapy aids in maintaining disease control and stability in MCD, surgery frequently leads to a full recovery in Unicentric Castleman Disease.

Following UCD surgery, recovery includes wound care and pain management, along with follow-up to make sure there is no recurrence. Patients with MCD may require ongoing care and routine monitoring for immune system activity, infections, and medication response.

Surgical treatment for UCD has a high success rate and is often curative. Modern treatments for MCD, such as monoclonal antibodies, have greatly enhanced results and provided efficient long-term disease management.

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Explore Hospitals ( 2 )

Apollo Multispecialty Hospitals

Kolkata, India

Apollo Multispecialty Hospitals located in Kolkata, India is accredited by JCI, NABH. Also listed below are some of the most prominent infrastructural details:

International patient Center
Focus on research and innovation
Different amenities: Transport, Security, Travel Desk, Places of Worship, Telecommunication Service, Special Nurse, Food & Dietary Services
Several kinds of rooms: General ward, Semi Private Rooms, Private Rooms, Deluxe, Super Deluxe, Suite, Maharaja Suite, HDU, Gastro ICU, Emergency, Neonatal ICU, Level 1, Level 2 & Level 3
Health Insurance coverage available
Here is a comprehensive list of the various kinds of key medical procedures performed through the latest technology.
Arthroscopy
Bone Marrow Transplant
Cosmetic Surgery
Da Vinci Robotic Surgical System
Fractional Flow Reserve (FFR)
Hand Microsurgery
Hip Arthroscopy
Minimally Invasive Cardiac Surgery
Minimally Invasive Subvastus Total Knee Replacement
Oral & Maxillofacial Surgery
128 Slice PET CT
Bioresorbable Vascular Scaffold (BVS)
ECMO
OCT Technique - Optical Coherence Tomography
Single Port Endoscopic technique of Carpal Tunnel Release (ECTR)

36

DOCTORS IN 13 SPECIALITIES

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Fortis Hospital

Kolkata, India

Fortis Hospital & Kidney Institute, Kolkata, is a 60-bed specialised centre for Urology and Nephrology, serving patients across Eastern India. Since its inauguration in 1999, the institute has pioneered advanced treatments like lithotripsy, laparoscopic donor nephrectomy, PCNL, and Holmium Laser prostate surgery, and has performed over 570 kidney transplants. Spread over 6 floors, it offers 4 operating theatres, a 12-bed dialysis unit, 24-hour renal emergencies, and a fully equipped laboratory, providing comprehensive, patient-focused care in renal and urological health.

20

DOCTORS IN 12 SPECIALITIES

17+

FACILITIES & AMENITIES

Price On Request

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Author

Nimra Haseeb

MSc Biochemistry

4 Years of Experience

Miss Nimra Haseeb is a medical researcher and a scientific content writer. She holds a Bachelor’s degree in Biotechnology and a Master’s in Biochemistry from Integral University, Lucknow.With strong experience in healthcare research, she specializes in secondary research, clinical data analysis, and evidence-based medical writing. Her work focuses on transforming complex scientific and medical information into clear, accurate, and reliable healthcare content for patients and healthcare audiences. She is also experienced in interpreting medical studies and healthcare trends to deliver well-researched and informative content that supports better health awareness and decision-making.. View More

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Dr Prateek Varshney

Surgical Oncologist

15 Years of Experience

Dr. Prateek Varshney is a renowned Surgical Oncologist. He has experience of more than 15+ years in surgical Oncology. He is currently practicing as a consultant at Metro Mass Hospital and Cancer Institute. He was also previously associated as a consultant with Sir Ganga Ram Hospital and as a professor at Gujarat Cancer Research Institute. View More

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