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Castleman disease is a group of rare disorders characterized by enlarged lymph nodes and a wide range of symptoms. The most common form of the disorder involves a single enlarged lymph node, typically found in the chest or neck, but it can occur in other areas of the body as well. This form is known as Unicentric Castleman Disease (UCD).

Multicentric Castleman Disease (MCD), on the other hand, involves multiple regions of enlarged lymph nodes, along with inflammatory symptoms and problems with organ function.

The goals of treating Castleman's illness are to reduce inflammation, alleviate symptoms, control aberrant lymph node cell growth, and avoid significant side effects, including cancer or infections. Whether the disease is widespread (Multicentric Castleman Disease, or MCD) or limited (Unicentric Castleman Disease, or UCD), the objective is to control it and enhance quality of life.

Consult a physician if you have fever, night sweats, enlarged organs, unexplained weight loss, swollen lymph nodes, or chronic exhaustion. MediGence's team of professionals can help you get an accurate diagnosis and a condition-specific care plan.

Preparation includes blood testing, imaging (CT, PET, or MRI scans), and lymph node biopsy to determine the disease subtype (ucd, HHV-8-associated MCD, or idiopathic MCD). Consult your doctor about all of your current medications and medical history. In multicentric instances, further HIV and HHV-8 screening might be necessary.

Surgical Removal: The afflicted lymph node is usually removed during surgery for UCD.
Medications: Corticosteroids, immunotherapy, antiviral medications (if HHV-8 positive), or chemotherapy are some of the medicines used to treat MCD.
Supportive Care: Monitoring organ function, preventing infections, and managing discomfort are all included in supportive care.
Follow-up: Continuous assessment using imaging and labs to evaluate response and modify therapy.

Surgical removal in UCD may require a brief hospital stay and a few weeks of recovery. Treatment for MCD involves continuous medication or therapy for several months under close observation. The length of treatment varies according to the severity and response of the disease.

There are no known risk factors for Unicentric Castleman Disease (UCD) or Idiopathic Multicentric Castleman Disease (iMCD), but individuals with HIV or weakened immune systems are at higher risk for Human Herpesvirus 8 (HHV-8) associated Multicentric Castleman Disease (MCD). In rare instances, Castleman disease can result in paraneoplastic pemphigus (PNP) in UCD patients and raise the risk of malignancies like lymphoma. Additionally, MCD may increase the risk of serious infections, which, if left untreated, can result in potentially fatal organ damage.

With timely and focused treatment, effective symptom management, lymph node reduction, prevention of complications, and general quality of life can all be achieved. While continuous therapy aids in maintaining disease control and stability in MCD, surgery frequently leads to a full recovery in Unicentric Castleman Disease.

Following UCD surgery, recovery includes wound care and pain management, along with follow-up to make sure there is no recurrence. Patients with MCD may require ongoing care and routine monitoring for immune system activity, infections, and medication response.

Surgical treatment for UCD has a high success rate and is often curative. Modern treatments for MCD, such as monoclonal antibodies, have greatly enhanced results and provided efficient long-term disease management.

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Explore Hospitals ( 3 )

Antalya Anadolu Hastanesi

Antalya, Turkey

Apart from in-detail treatment procedures available, Antalya Anadolu Hastanesi located in Antalya , Turkey has a wide variety of facilities available for International Patients. Some of the facilities which are provided by them are Accommodation, Airport Transfer, Choice of Meals, Interpreter, TV inside room. Also listed below are some of the most prominent infrastructural details:

A technological powerhouse, it provides 24*7 trauma care.
4 suites and 54 luxurious rooms
3 exceptional operating theatres
3 Intensive Care Units
Efficient and capable healthcare personnel
Focus on patient care, reasonable prices
State of the art diagnostics setup
Recognised for providing integrated care for complex cases and rare cases
Latest 1.5 Tesla MR, 64 2 Multi-slice Computed Tomography (CT), coronary angiography, and panendoscope
Treatments such as angioplasty(PTCA), cryotherapy, IVF, ERCP, peritoneoscopy, facial palsies, and electro shock wave lithotripsy are available
Widely experienced and well educated healthcare professionals are at the forefront of healthcare delivery at the Antalya Anadolu Hospital, Antalya, Turkey

10

DOCTORS IN 14 SPECIALITIES

17+

FACILITIES & AMENITIES

Price On Request

Memorial Antalya Hospital

Antalya, Turkey

Memorial Antalya Hospital located in Antalya, Turkey is accredited by JCI. Also listed below are some of the most prominent infrastructural details:

114 patients and 28 intensive care beds
5 Operating theatres
Radiology Department with advanced technology
Intensive care units
Interventional Radiology Unit
Chemotherapy and Art Center
The Hospital uses advanced technologies like Hydra Facial, Cardiac MR, Heart Tomography-Coronary CT Angiography and many more
Patient rooms and living spaces with all the 5-star hotel features

24

DOCTORS IN 12 SPECIALITIES

20+

FACILITIES & AMENITIES

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Medical Park Antalya Hospital

Antalya, Turkey

Apart from in-detail treatment procedures available, Medical Park Antalya Hospital located in Antalya, Turkey has a wide variety of facilities available for International Patients. Some of the facilities which are provided by them are Accommodation, Airport Transfer, Choice of Meals, Interpreter, TV inside room. Also listed below are some of the most prominent infrastructural details:

84 Polyclinics
Capacity for 228 beds (39 in Heart Hospital)
73 Intensive Care Units
10 coronary Intensive Care Units
7 CVS
22 General Intensive Care Units
34 neonatal intensive care Units
10 Operating rooms equipped with organ transplant surgery standards
Aviation Medical Center
Hair Transplantation Clinic

25

DOCTORS IN 10 SPECIALITIES

22+

FACILITIES & AMENITIES

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Author

Nimra Haseeb

MSc Biochemistry

4 Years of Experience

Miss Nimra Haseeb is a medical researcher and a scientific content writer. She holds a Bachelor’s degree in Biotechnology and a Master’s in Biochemistry from Integral University, Lucknow.With strong experience in healthcare research, she specializes in secondary research, clinical data analysis, and evidence-based medical writing. Her work focuses on transforming complex scientific and medical information into clear, accurate, and reliable healthcare content for patients and healthcare audiences. She is also experienced in interpreting medical studies and healthcare trends to deliver well-researched and informative content that supports better health awareness and decision-making.. View More

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Dr Prateek Varshney

Surgical Oncologist

15 Years of Experience

Dr. Prateek Varshney is a renowned Surgical Oncologist. He has experience of more than 15+ years in surgical Oncology. He is currently practicing as a consultant at Metro Mass Hospital and Cancer Institute. He was also previously associated as a consultant with Sir Ganga Ram Hospital and as a professor at Gujarat Cancer Research Institute. View More

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