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Castleman disease is a group of rare disorders characterized by enlarged lymph nodes and a wide range of symptoms. The most common form of the disorder involves a single enlarged lymph node, typically found in the chest or neck, but it can occur in other areas of the body as well. This form is known as Unicentric Castleman Disease (UCD).
Multicentric Castleman Disease (MCD), on the other hand, involves multiple regions of enlarged lymph nodes, along with inflammatory symptoms and problems with organ function.
The goals of treating Castleman's illness are to reduce inflammation, alleviate symptoms, control aberrant lymph node cell growth, and avoid significant side effects, including cancer or infections. Whether the disease is widespread (Multicentric Castleman Disease, or MCD) or limited (Unicentric Castleman Disease, or UCD), the objective is to control it and enhance quality of life.
Consult a physician if you have fever, night sweats, enlarged organs, unexplained weight loss, swollen lymph nodes, or chronic exhaustion. MediGence's team of professionals can help you get an accurate diagnosis and a condition-specific care plan.
Preparation includes blood testing, imaging (CT, PET, or MRI scans), and lymph node biopsy to determine the disease subtype (ucd, HHV-8-associated MCD, or idiopathic MCD). Consult your doctor about all of your current medications and medical history. In multicentric instances, further HIV and HHV-8 screening might be necessary.
- Surgical Removal: The afflicted lymph node is usually removed during surgery for UCD.
- Medications: Corticosteroids, immunotherapy, antiviral medications (if HHV-8 positive), or chemotherapy are some of the medicines used to treat MCD.
- Supportive Care: Monitoring organ function, preventing infections, and managing discomfort are all included in supportive care.
- Follow-up: Continuous assessment using imaging and labs to evaluate response and modify therapy.
Surgical removal in UCD may require a brief hospital stay and a few weeks of recovery. Treatment for MCD involves continuous medication or therapy for several months under close observation. The length of treatment varies according to the severity and response of the disease.
There are no known risk factors for Unicentric Castleman Disease (UCD) or Idiopathic Multicentric Castleman Disease (iMCD), but individuals with HIV or weakened immune systems are at higher risk for Human Herpesvirus 8 (HHV-8) associated Multicentric Castleman Disease (MCD). In rare instances, Castleman disease can result in paraneoplastic pemphigus (PNP) in UCD patients and raise the risk of malignancies like lymphoma. Additionally, MCD may increase the risk of serious infections, which, if left untreated, can result in potentially fatal organ damage.
With timely and focused treatment, effective symptom management, lymph node reduction, prevention of complications, and general quality of life can all be achieved. While continuous therapy aids in maintaining disease control and stability in MCD, surgery frequently leads to a full recovery in Unicentric Castleman Disease.
Following UCD surgery, recovery includes wound care and pain management, along with follow-up to make sure there is no recurrence. Patients with MCD may require ongoing care and routine monitoring for immune system activity, infections, and medication response.
Surgical treatment for UCD has a high success rate and is often curative. Modern treatments for MCD, such as monoclonal antibodies, have greatly enhanced results and provided efficient long-term disease management.
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Sri Ramachandra Medical Centre
Chennai, India
2.9 ( 1 Reviews )
Sri Ramachandra Medical Centre located in Chennai, India is accredited by ISO, JCI, NABH, NABL. Also listed below are some of the most prominent infrastructural details:
- The best minds in healthcare including specialists, and other healthcare professionals work together to treat patients with simple to complex and critical conditions.
- The number of inpatients and outpatients (annually) are 35,000 and 2,50,000 respectively.
- A wide range of surgical specialties, sub specialties are available in Sri Ramachandra Medical Centre Chennai.
- The bed capacity of the hospital is 800 which is inclusive of 200 Intensive Care Unit beds.
- Blood Bank and Eye Bank are available on a 24/7 basis.
Jaypee Hospital
Noida, India
Jaypee Hospital located in Noida, India is accredited by ISO, NABH, NABL. Also listed below are some of the most prominent infrastructural details:
- 525 beds in the first phase
- 150 Critical Care beds
- 325 ward beds with Suite, Deluxe, Twin Sharing, and Economy options
- 18 Modular OTs
- 4 Cardiac Catheterization Lab with unqie Hybrid Operating Room
- 24 bedded Advanced Neonatal ICUs20 bedded Dialysis Units
- 2 Linear Accelerator (IMRT, VMAT, I
- GRT), Wide Bore CT Simulator, one Brachytherapy Suite
- True Beam STx Linear Accelerator
- 2 MRI (3.0 Tesla) with High-Intensity Focused Ultrasound
- 64 Slice PET CT, Gamma Camera, Dual Head 6 Slice SPECT CT
- 256 Slice CT Scan, CT Simulation
- Amongst the few GOLD LEED-certified hospital buildings in India
- Appointment Scheduling
- Flow motion 64 Slice PET CT technology
- Pick and drop facility from/to the Airport
- Foreign exchange facility
- Treatment packages
- Visa assistance
- Admission in the hospital
- Wi-Fi/internet service in the room
- Travel arrangement for patient & attendant after discharge
- Tele-consults after discharge
- Dedicated Guest House for International Patients maintained by Jaypee Hospital
- In-house translators for patient’s comfort
- Assistance in getting doctor’s opinion
- Registration with the Foreigners Regional Registration Office
- Accommodation arrangements after discharge
- Accommodation arrangement for the accompanying attendant
- Customized diet for patient and attendant
- Laundry services
- Prayer room
- Dialysis facility for 60 patients
- Cadaver organs
- Blood bank facilities
- Advanced Laboratory facilities
- Diagnostic and Radiology facilities
- High-end Ultrasound facilities
Fortis Hiranandani Hospital
Mumbai, India
- Fortis Hiranandani Hospital, Vashi, Navi Mumbai, is a leading NABH-accredited multi-super speciality hospital offering advanced tertiary care with over 150 beds.
- The hospital is known for clinical excellence in Cardiac Sciences, Oncology, Neurology, Orthopaedics, Organ Transplants, Urology, Gastroenterology, and Critical Care.
- With a strong team of experienced doctors, modern medical technology, and international patient services, the hospital provides comprehensive and patient-focused treatment.
- It maintains high standards of safety, hygiene, and quality care, making it a trusted healthcare destination in the Mumbai Metropolitan Region.
Fortis Hospital, Shalimar Bagh
Delhi, India
4.5 ( 4 Reviews )
- Fortis Hospital, Shalimar Bagh, New Delhi, is a leading multi-super-speciality hospital established in 2010, known for advanced medical technology and compassionate patient care.
- The hospital has 375 beds, including 166 ICU beds, and features 10 modular operating theatres along with specialised ICUs and Level III NICU/PICU. Fortis Shalimar Bagh offers care across Cardiology, Neurosciences, Oncology, Orthopaedics, Transplants, Urology, and Mother & Child Health, supported by NABH and NABL accreditation.
- Equipped with cutting-edge technology like the Da Vinci Surgical Robot, PET-CT Scanner, and CORI Robotic System, the hospital is recognised for excellence in treatment outcomes, patient comfort, and multidisciplinary care, making it a trusted destination for both domestic and international patients.
Aakash Healthcare Super Speciality Hospital
Delhi, India
Aakash Healthcare Super Speciality Hospital located in New Delhi, India is accredited by NABH. Also listed below are some of the most prominent infrastructural details:
- One of the biggest tertiary care hospitals in India
- Facility is fusion of state of the art technology, competent clinicians, and world-class infrastructure
- 230 beds
- 70 bedded medical and surgical and Critical Care Unit
- Ward Bed Options- Twin, Deluxe, Sharing and Economy
- Pneumatic Tube System
- Ambulance Services 24x7
- 15 Bedded dialysis unit
- Advanced Neonatal ICU
- Advanced imaging services, including magnetic resonance imaging, computed tomography scanning, digital mammography, ultrasound
- 8 modular OTs
- Flat Panel Cath Labs
- LASIK - SMILE Suite
- Wellness Lounge
- State-of-the-art diagnostic equipment
- 15 Dialysis beds
- 24x7 ‘Trauma & Emergency Center
- Dedicated blood bank
- 24x7 comprehensive patient care.
- Deployed high-end technologies & smart digital system
- Robust Hospital Information Systems to meet complex medical needs of patients
- Robotic assisted surgeries
- International Patients Lounge
- Airport Pick-up and Drop
- Accommodation and Food for Attendant
- Language Interpreter Services
- 4 triage beds, a dedicated sample collection room, 6 observation beds, and highly skilled emergency staff
- Robotic knee replacement surgery
- ATM
- Lounge for visitors
- Internet Access: The whole facility is Wi-Fi enabled
- Travel Desk: Provides an all-round patient care.
- 24x7 pharmacy
Aster Medcity
Kochi, India
- 670 bed facility
- 24 hours Emergency and Trauma Care
Aster Centres of Excellence
- Cardiac Sciences
- Orthopaedics & Rheumatology
- Neurosciences
- Nephrology & Urology
- Oncology
- Gastroenterology
- Integrated Liver Care
- Womens Health
- Child & Adolescent Health
- Multi Organ Transplant
- Diagnostic Technology used for increasing the efficiency of diagnostic procedures.
- Streamlined Application of Therapeutic Technology
- Minimal Access Robotic Surgery (MARS) which makes use of the da Vinci Surgical System is applied by the specialists in Aster Medcity, Kochi, Kerala.
- ORI Fusion Digital Integrated Operation Theatres which applies Karlstorz OR1 Fusion system.
- Completely digital Anesthesia facility
- Pharmacy which possesses completely Automated Drug Dispensing
Medicana Camlica Hospital
Istanbul, Turkey
4.2 ( 2 Reviews )
Medicana Camlica Hospital located in Istanbul, Turkey is accredited by JCI. Also listed below are some of the most prominent infrastructural details:
- 150 bedded Hospital
- Specialty-based clinics
- Fully-equipped patient rooms
Memorial Sisli Hospital
Istanbul, Turkey
Memorial Sisli Hospital located in Istanbul, Turkey is accredited by JCI. Also listed below are some of the most prominent infrastructural details:
- Operates in a closed area of 53,000 sqm
- Capacity of 252 beds
- 13 Operating rooms
- 4 Intensive Care Units (KVC, General, Coronary, Neonatal)
- 3 Laboratories
- Organ Transplantation Center
- IVF Center
- Genetic Center
- Stroke Center
- Breast Health and Disease Center
- Oncology Center
- Da Vinci Robotic Surgery Center
- Bone Marrow Transplantation Center
Hisar Intercontinental Hospital
Istanbul, Turkey
Architecture of the Hospital designed as per the comfort of patients-
- Consisting of 8 floors, 212 bed capacity
- 75m2 suite rooms
- 35 thousand m2 closed area
- 7 operating rooms
- 53 polyclinics
- 54 Departments
- Hotel-like patient rooms
- Intensive care units consisting of 33 beds
- Hyperbaric Oxygen Center inside the hospital
- PYXIS computerized medicine system working with fingerprint
- Social waiting areas
- Indoor and Outdoor Cafeterias & Restaurants
NMC Specialty Hospital
Abu Dhabi, United Arab Emirates
NMC Specialty Hospital located in Abu Dhabi, United Arab Emirates is accredited by JCI. Also listed below are some of the most prominent infrastructural details:
- 104 Patient Rooms/Wards
- 7 Operating Rooms
- Laboratory endowed with centrally computerized System
- 24-hour Emergency Department
- 24-hour Pharmacy
- 24-hour Ambulance Services
- Radiology Department offering state-of-the-art equipment, including MRI (1.5 Tesla), 64-slice spiral CT Scanner, 4-D Ultrasound with color Doppler, Bone Densitometry, Digital Mammogram with CAD System, and Digital X-Ray Systems with fully integrated PACS
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