What Are The Four Major Stages of Liver Disease

What Are The Four Major Stages of Liver Disease

Our liver is a very active organ performing over 500 functions. The importance of liver health can not be overstated. Still, many people are neglectful of it.  This leads to liver disease that can progress to liver failure. Such a condition would require a liver transplant.  When we have liver disease,  there is a step-wise descent in our liver health which we have enumerated below:

Stages of Liver Disease

1. Inflammation

Stages of Liver Disease - Inflammation

This is the first stage where various agents damage the liver cells leading to enlargement of the liver. This diseased inflammation is known as hepatitis. Due to this,  the person experiences abdominal pain, specifically in the upper right quadrant of the abdomen. At this stage, the disease can be treated. However, people with non-alcoholic fatty liver disease may not experience any symptoms at this stage.

2. Fibrosis

Stages of Liver Disease - Fibrosis

If the liver disease is not detected early, it can lead to fibrosis or scarring.  Fibrosis distorts the shape and blood flow of the liver. When the tissues stop receiving blood, they become necrotic and eventually die. Slowly, the scar tissue replaces the healthy tissue in the liver.

Fibrosis is marked by persistent inflammation and excessive deposition of collagen that stiffens the liver.  Lifestyle changes and medications at this stage could help in reversing the condition to some degree.

3. Cirrhosis

Stages of Liver Disease - Cirrhosis

This is defined as irreversible scarring of the liver. There is no possibility of liver healing and it becomes permanently damaged. This phase is associated with symptoms like discomfort, tenderness in the abdomen where the liver is present, and pain. The patient may also have jaundice. It takes a long time to get to this stage. People with cirrhosis also have a high chance of developing liver cancer. Some of the conditions that could cause cirrhosis are:

  • A long history of alcohol abuse
  • Long-term chronic viral hepatitis
  • Diabetes
  • Obesity
  • Accumulation of fat in the liver like in the case of non-alcoholic fatty liver disease
  • Hemochromatosis that leads to iron buildup
  • Wilson’s disease
  • Cystic fibrosis
  • Infection with brucellosis and syphilis
  • Medicines like isoniazid

4. Liver failure

If cirrhosis is left unattended, it can progress to liver failure. At this stage, the liver stops functioning altogether.  Liver failure can be acute or chronic. Acute liver failure occurs within a short span of 48-72 hours. It usually happens as a consequence of drug overdose or toxicity. Chronic liver failure occurs more slowly and usually progresses through each stage. In this type of liver failure, the patient experiences weight loss, diarrhea, nausea, and vomiting. The person may also undergo mental and cognitive changes,  often feeling confused.  This requires immediate action but liver failure cannot be treated.

A liver transplant is the only option in case of liver failure. The patient can be put on life support till a matching liver is found. But it has to be transplanted soon to save the patient’s life.

Avail Liver Transplantation Across the World

Liver Transplant in Different Countries Starting Cost in USD
Liver Transplant in India $25090
Liver Transplant in Turkey $52710
Liver Transplant in Thailand $65000
Liver Transplant in Singapore $290000
Liver Transplant in Israel $350000
Liver Transplant in South Korea $250000


In most cases, patients are unaware that they have liver disease. This allows the disease to progress. Reading through these stages of liver disease makes us realize how vital it is to take care of our liver to prevent severe consequences. By adopting a healthy lifestyle and getting blood tests done regularly, we may be able to create a roadblock to its progression.

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Last modified on blank at Jan 05, 2023

Reviewed By :- Guneet Bhatia

Urvi Agrawal

Urvi is an avid reader who is passionate about writing. Having worked in hospital settings like AIIMS, She has experience working as a healthcare writer and has written about many healthcare and medical topics. Besides her role as a content specialist, she likes to spend her time cooking, dancing, and painting. She believes that positive thinking is crucial for being happy.

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