The Centre of Excellence in Oncology at Manipal Hospital, Yeshwantpur, takes a comprehensive approach to treat cancer at all stages. The department offers a full range of Oncology Clinical Specialties, including Surgical, Medical (Chemotherapy, Immunotherapy, and Hormone Therapy), Radiation Therapy, Hematology, and Bone Marrow Transplantation.

Manipal Hospitals' expert team is extremely skilled at diagnosing the most difficult cases, staging the disease, treating with medications, radiotherapy, or operating with cutting-edge technology including biological therapies, robotic surgery, stereotactic ablative radiotherapy (SBRT), Electrons for superficial tumors, Radio guided cancer surgery, Volumetric modulated arc therapy, Intra Cavitary Radio Therapy, and 3 Dimensional Conformal Radio Therapy. The hospital offers palliative care to patients under skilled experts and surgeons. They also guide patients toward effective recovery.