Stem Cell Therapy for Multiple Sclerosis (MS)

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Overview

Multiple sclerosis (MS) is a brain and spinal cord condition that can be devastating (central nervous system). The protective sheath (myelin) that surrounds nerve fibres is attacked by the immune system in MS, causing communication issues between the brain and the rest of the body. The condition might eventually cause permanent nerve injury or degeneration.

Some MS facts:

MS is associated to increased depression and anxiety in patients, as well as a lower quality of life.
It can result in a reduction in work capacity as well as a decreased ability to participate in society.
According to the most comprehensive global survey to date, 2.8 million people worldwide have multiple sclerosis (MS). That implies someone with MS is diagnosed every 5 minutes somewhere on the planet.
In the United States, about a million of them live.
Body fat may play a role in MS in women. According to a study, women carry more fat on their bodies than males, putting them at a higher risk of MS.
The majority of people with MS are diagnosed between the ages of 20 and 50 years, but it can occur at any age.
MS is more common in northern European and American areas, but it can appear in any geographic location, according to the Atlas of MS

The amount of nerve damage and which nerves are damaged determine the signs and symptoms of MS. Some persons with severe MS lose their ability to walk independently or at all, while others go into remission for long periods of time without experiencing any new symptoms.

Since then, multiple sclerosis has remained incurable. Stem cell therapy, on the other hand, can assist in speedy recovery from attacks, change the course of the disease, and manage symptoms without causing any further complications. Stem cell has emerged as a new breakthrough for Multiple sclerosis in 2022. Patients with Multiple Sclerosis may benefit from stem cell therapy. Mesenchymal stem cells can lower inflammation and modify the immune system, which could be tremendously advantageous for MS sufferers.

To know more about it, continue reading…

Symptoms and Causes of Multiple Sclerosis (MS)

Symptoms

Fatigue- According to the National Multiple Sclerosis Society, about 80% of patients with MS experience fatigue (NMSS). MS-related fatigue might make it difficult to carry out day-to-day activities.
Walking difficulty- With MS, you may have difficulties walking, as well as numbness in your legs or feet, difficulty balance, muscular weakness, muscle stiffness, and vision problems.
Vision Problems- Many persons with MS experience vision issues as one of their early symptoms. One or both eyes may be affected by vision difficulties. These problems may appear and disappear, or they may worsen over time. They can also be completely resolved. Optic neuritis, which causes pain or hazy vision in one eye, diplopia, or double vision, and nystagmus, or involuntary eye movement, are all typical vision disorders linked with MS.
Lhermitte’s sign- A person may experience a sensation like an electric shock when they move their neck, known as Lhermitte’s sign.
Speaking difficulties- MS develops brain lesions that might impair speech. Dysarthria is a term for a variety of speech problems that can range from mild to severe. Slurred speech, “scanning” speech (where there are extended pauses between words or syllables), and fluctuations in voice volume are all symptoms of dysarthria.
Other symptoms- Acute or chronic pain, tremors, cognitive challenges such as attention, memory, and word identification, trouble eating and swallowing, sleeping problems, and bladder control problems are all common MS symptoms.

Causes

Multiple sclerosis has no recognised origin. It’s classified as an autoimmune disease because the immune system attacks the body’s own tissues. This immune system dysfunction in MS causes the fatty substance that coats and protects nerve fibres in the brain and spinal cord to be destroyed (myelin).
Myelin is similar to the insulation that protects electrical cables. The messages that go along that nerve fibre may be slowed or inhibited if the protecting myelin is broken and the nerve fibre is exposed.
It’s unclear why some people develop MS and others do not. It appears that a combination of hereditary and environmental variables is to be responsible.

Types of Multiple Sclerosis Stages Treated by Stem Cell Therapy

Clinically isolated syndrome (CIS)-

A pre-MS disease characterised by a single bout of symptoms lasting at least 24 hours is known as CIS. Demyelination of the CNS is the cause of these symptoms. Although this experience is typical of MS, it isn’t enough to diagnose the disease. You’re more likely to be diagnosed with RRMS if you have more than one lesion or a positive oligoclonal band (OCB) in your spinal fluid during a spinal tap. You’re less likely to be diagnosed with MS if these lesions aren’t present or if your spinal fluid doesn’t reveal OCBs.

Relapsing-remitting MS (RRMS)-

Clear relapses of disease activity are followed by remissions in relapsing-remitting MS (RRMS). Symptoms are minor or nonexistent during remission periods, and disease progression is modest to moderate. According to the National Multiple Sclerosis Society, RRMS is the most frequent form of MS at the time of start, accounting for around 85 %.

Primary-progressive MS (PPMS)-

If you have primary progressive MS (PPMS), your neurological function will deteriorate over time as your symptoms worsen. Short periods of stability can, however, occur. When there are new or enhancing brain lesions, the terms “active” and “not active” are occasionally employed to indicate disease activity. PPMS affects about 15% of patients with MS.

Secondary-progressive MS (SPMS)-

Secondary-progressive multiple sclerosis (SPMS) is a form of multiple sclerosis. After relapsing-remitting MS, it’s considered the following stage (RRMS). There are no longer any evidence of remission in SPMS. This indicates that despite treatment, the illness is deteriorating.

Importance of Stem Cell Therapy for Multiple sclerosis

MS is a silent & chronic disease, which affects younger adults often women. MS can be difficult to diagnose and its symptoms could vary person to person.

Issues with the traditional treatment methods-

Unfortunately, a cure doesn’t exist yet for multiple sclerosis (MS). Current MS treatment procedures try to relieve symptoms but do not address the underlying problems. Worse, many of the medications used to treat MS symptoms have negative side effects and are unable to prevent disease progression in many patients. Finally, the costs of these treatments often put a strain on the patient’s finances. For example, an annual regimen of Ocrevus (ocrelizumab), a newer medicine, can cost upwards of $65,000 USD.

Stem cell treatment for MS-

A person with MS has a variety of treatment choices, including stem cell therapy. Stem cells are cells that have the ability to convert into different cell types. They can also renew, producing an endless supply of new cells. This makes them beneficial in the treatment of MS. The healing and repair-promoting characteristics of stem cell therapy for MS have been proven. The use of umbilical cord cells produced from enlarged cord tissue has the potential to improve MS treatment. MSCs (mesenchymal stem cells) can help the body fight inflammation. Stem cells will help to regulate the immune system and prevent future myelin breakdown once they have been delivered. This makes mesenchymal stem cells (MSCs) a promising treatment option for MS and other diseases marked by inflammation and/or tissue damage.

Eligibility of Stem Cell Therapy for Multiple Sclerosis

While there is no cure for MS, stem cell therapy can reduce patients’ symptoms and decrease the disease’s development. As a result, there are no eligibility requirements unless the patient has Multiple Sclerosis (any of the conditions).

Other factors on the basis of Multiple sclerosis condition are evaluated-

Age (between 20-50 years)
Presence of other illness
Undergone any treatment or surgery earlier or not
Lifestyle habits and many more

Stem Cell Treatment Protocol used for COPD by GAIA (in association with CEMAB)

Although there is no cure for MS, there are treatments that help delay the disease’s course, lessen the number and severity of relapses, and alleviate symptoms.

Scientists and doctors are increasingly looking into using stem cell treatment to regenerate various bodily cells and restore function to patients who have lost it due to medical reasons. CEMAB (in partnership with GAIA) has developed treatment protocols for every condition that can be treated with stem cell therapy. The MS protocol tries to lower the body’s overall levels of chronic low-grade inflammation. The consequences are expected to linger for a long period.

Treatment Protocol-

Two-day protocol centers on the intrathecal transplant of stem cells
A minimum of 120 million cord tissue-derived MSCs (Mesenchymal Stem Cells) are injected directly into the spinal canal
The procedure takes approximately 45 minutes, is minimally invasive, and has very little downtime
Patients normally travel home two days following their scheduled appointment.

Researchers hope that one day, stem cell therapy techniques may be able to reverse the damage done by MS and restore functionality in the nervous system.

Advantages of Stem Cell Therapy for Multiple Sclerosis

Multiple sclerosis (MS) is a neurological and autoimmune disease in which the body’s immune system turns against itself. Stem cell therapy, specifically utilising mesenchymal stem cells (MSCs), has shown considerable promise in the treatment of the disease. Since stem cell therapy can be both immunomodulatory (meaning it can control the immune system) and regenerative, it’s a promising treatment option for MS and other diseases marked by inflammation and tissue degeneration. Transplantation with mesenchymal stem cells (MSCs) has also been demonstrated to reduce the course of MS in patients. MS Patients may be able to expect an increase in energy, flexibility, strength, mobility, and control of basic function.

MS-specific advantages you can avail with stem cell therapy are-

Promote cell regeneration
Replaces damaged & diseased tissues
Reduced inflammation
Improved energy
Modulate immune system
Improved symptom management

Other benefits of Stem cell treatment for COPD, especially from GAIA (in association with CEMAB) via MediGence-

No hospitalization required
No surgical intervention
No delayed recovery
Long-lasting results without any permanent side effects
Virtual consultation available before treatment

How To Apply For Stem Cell Treatment for Multiple Sclerosis?

Applying for stem cell therapy is very convenient and hassle-free for you through MediGence-

Step1– Send us an inquiry with relevant details of your condition
Step2– Our team of experts will validate your case
Step3– A dedicated patient care manager will be assigned to your case
Step4– Once validated, you can also avail a tele-consultation with our stem cell specialist

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Frequently Asked Questions

Can stem cells treat Multiple sclerosis problems permanently?

For Multiple Sclerosis, stem cell therapy, specifically the infusion of mesenchymal stem cells (MSCs), has shown considerable promise in terms of improving symptoms and stabilising disease progression. MSCs have been shown in many models to have immunomodulatory (ability to modulate the immune system), tissue-protective, and repair-promoting capabilities, making them an appealing therapy for Multiple Sclerosis (MS) and other disorders defined by inflammation and/or tissue injury. The only question is how long it can last, as there is no proof of that. However, 5 years following treatment, it was discovered that 69% of those who had stem cell therapy did not experience a relapse in MS symptoms or new brain lesions produced by MS.

How does stem cell therapy work for Multiple sclerosis?

Multiple sclerosis (MS) is a central nervous system autoimmune disease. It causes the immune system to target the brain, spinal cord, and optic nerve, among other areas of the central nervous system. While there is no cure for MS, stem cell therapy can reduce patients’ symptoms and decrease the disease’s development. People can participate in clinical trials for stem cell therapy, which is an experimental treatment. Different types of stem cells are used in different types of stem cell transplant. Mesenchymal stem cell (MSC) therapy is another potential treatment for the symptoms of MS. MSCs can help with myelin repair and have a beneficial influence on the immune system. A clinician extracts MSCs from a person’s bone marrow, blood, or other tissues during MSC therapy. They then multiply these cells in a lab before reintroducing them into their bodies in larger quantities.

They might do so to help cells suppress immune responses that injure the nervous system and aid in myelin repair. In a study after many clinical trials, researchers & doctors found some facts about MSCs such as-

their ability to modulate a person’s immune system
their release of trophic factors, which are molecules that help neurons in the brain develop
their ability to differentiate into a wide variety of other cells
their ability to regenerate

Why Do International Patients Trust Us?

MediGence is a health-tech organization that specializes in improving quality healthcare accessibility using its innovative set of tools and technology. With a global network of internationally certified and recognized healthcare providers, we strive hard to simplify the complexity in availing the expert second opinion (named thinkTWICE), online virtual consultation (Telemedicine), Treatment overseas (multiple options), Treatment with complimentary additional benefits & discounts (Prebundled packages), and Post-operative care (comprehensive patient care with post-op packages). Many other services are still in progress.

Following the HIPAA and GDPR compliances, MediGence became one of the first companies certified by TEMOS for upholding international quality standards.

MediGence has always placed a premium on gaining and maintaining the trust of its patients and the physicians with whom it works. We’ve always strived for excellence and expanded our service offerings to our patients in order to increase healthcare accessibility and quality of life for them. We’ve formed a number of useful and reputable partnerships with world-class hospitals and doctors all over the world. We, like the others, have brought GAIA from Colombia (a world-renowned stem cell advanced laboratory in association with CEMAB) on board, as we recognize the importance of stem cells in the future. Stem cells are often regarded as the medicine of the future.

Some major values that we follow are-

Our focus is safety, efficacy, and patient-centric care when providing access to superior stem cell therapy and other treatment techniques
We utilize only board-certified surgeons, physicians, and accredited clinicians to provide care for patients.
A clinical team with expertise in practicing stem cell therapy for various conditions at GAIA & CEMAB
Methods of administering stem cells that steer them to certain conditions
Skilled Patient Advocates/Advisors who are trained to provide truthful, realistic expectations resulting from stem cells therapy. We do not make outlandish promises of cures or inaccurate claims related to improvement rates

We have numerous reasons as to why choose us for your medical accessibility partner-

Patients’ convenience is our motto and for that, in these years of our existence, we have launched patient-centric services & products such as Telemedicine, thinkTwice, Prebundled & Prenegotiated Packages for availing treatment abroad with additional benefits, our network of 4000+ doctors in 20+ countries, our exploring platform for multiple treatments overseas, our logistics arrangement, and much more.
MediGence ensures that you receive complete attention and a stress-free medical experience in addition to delivering products and services. Keeping this in mind, we’ve assigned specialist case managers to your case, who will handle all of your coordination with the doctor, healthcare staff, and hospital, as well as any other necessary logistics arrangements.
Not only do we have a large network of healthcare providers visiting or connecting with us from all over the world, but we also have a wide network of patients who have complete faith in us to handle their entire medical journey. We have been the most popular healthcare providers among patients from Turkey, India, Russia, Spain, Singapore, Lithuania, the United Arab Emirates, the United States, the United Kingdom, and a variety of other countries.
We chose to work with GAIA for stem cell therapies because we wanted to broaden our service offerings and help suffering people all over the world avoid invasive surgical procedures.
Together, we are providing stem cell treatment for successfully treating autoimmune or inflammatory diseases like Autism, Multiple Sclerosis, Parkinson’s, Arthritis, Lupus, Inflammatory Bowel Disease, Diabetes, Psoriasis, Graves’ Disease, and many others – often with breathtaking results.
We have a network of several doctors from Central and South America. who have helped thousands of patients restore their health with STEM CELL therapies. They have demonstrated an impeccable safety profile, and the results have often been breathtaking, utilizing these advanced treatments that are not available in the world.
We work with pioneers of stem cell science who have bought this cutting-edge technology in the world and that too at affordable rates.
Many celebrities have benefited from stem cell therapies and they have also encouraged people in many talk shows by telling them the advantages of stem cells.
There is no compromise on the treatment quality due to reduced prices, as we have already established beneficial mutual collaborations with the hospitals & doctors.
Before undertaking the stem cell treatment, MediGence always prefers you to consult with the specialists via phone consultation or teleconsultation, which can help you with more clarity regarding your condition and treatment eligibility, possibilities, durability, & other factors.

Providing an epilogue to the above benefits with MediGence, we have-

150+ years of collective healthcare and technology experience
Patient-centric approach with a focus on well-being
Affordable healthcare options worldwide
Ease of access of the world’s best healthcare
Patients’ data privacy by complying to HIPAA and GDPR compliance

Is Stem Cell treatment safe?

It is, without a doubt, a risk-free procedure, which does not require any surgical technique. Anti-inflammatory medicines, in combination with other therapy, are now used to treat Multiple Sclerosis. Current treatments, on the other hand, are ineffective. CEMAB (in association with GAIA) concluded after years of hard labour and research that cord-derived mesenchymal stem cell transplantation is a safe and effective therapy option for patients with moderate to severe Multiple sclerosis.

How long do I have to stay in the country for the procedure and follow-up consultations?

A single stem cell session for MS takes roughly 45 minutes and does not necessitate surgery. After two days of treatment, patients usually fly home, and rehabilitation is contingent on follow-up visits. Before you return home, you and your caregiver must prepare for this adjustment. You’ll still need to take steps to keep healthy and avoid disease. Participation in the planning of your at-home care is essential. Your transplant team will work with you to make plans for your follow-up treatment before you depart. MediGence will assist you in scheduling follow-up appointments with CEMAB’s stem cell specialists.

Is it possible to consult a Stem Cell specialist before I decide to travel?

Consultation with a CEMBAB Stem cell specialist prior to planning a medical journey for your disease is not only possible, but essential. Telemedicine not only makes it easier to monitor a patient’s health through technology, but it also reduces the need for a patient to visit a specialist in person. Prescriptions can be confirmed and tests can be recommended by the specialist. It also reduces the effort necessary by homebound patients who can seek medical advice without having to visit a hospital or healthcare facility. This consultation will also help you make an informed decision about this new age treatment. It will provide you with the necessary assurance and assistance with the resources that a stem cell treatment entails.

Is it possible to consult a Stem Cell specialist before I decide to travel?

How can MediGence assist in the overall process?

Individuals have different rates of advancement and different symptoms. With this in mind, MediGence has committed to assisting you at every stage of your stem cell journey. Our combined 150+ years of healthcare experience serve as a source of strength. For your convenience, we have stem cell experts, qualified and experienced patient advocates, specialised case managers, and a 24-hour consultation service.

The following is the response to the question of how we can help you with the complete stem cell process-

MediGence connects you with a network of certified & most recognized doctors and our patient-centric services
MediGence is in-charge of your complete stem cell treatment process, from booking to recovery.
MediGence- Walks you through the full treatment process as well as the benefits you’ll receive.
Transparently displays the cost of stem cell therapy for each disease/condition
In just a click, we will established your contact with one of our ‘Stem cell specialists’ for a quick chat about your eligibility and treatment protocol.
Make an appointment with your doctor for an online consultation via Telemedicine, before you travel.
Make an appointment with GAIA for your treatment.
When you’re ready to fly for treatment, make your plans.
Your treatment plan includes follow-up consultations.

Before initiating a treatment/procedure, MediGence will ensure that you receive all essential answers during your consultation. That’s why we recommend calling us and speaking with one of our knowledgeable representatives. Schedule a personal, one-on-one appointment to discuss your concerns and learn more about our cutting-edge treatments to see if stem cell Spinal cord injury treatment is right for your child. Please contact us right away!

References:

Amit Bansal

Amit Bansal is a serial entrepreneur, Co-Founder, and CEO of MediGence. He has more than 17 years of strong technology experience. Having worked for some of the recognized companies in India, Australia and traveled worldwide to help businesses to grow multi-folded under his leadership and strategic guidance.

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