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What is an Ependymoma?

Ependymoma is a central nervous system (CNS) tumour that develops from ependymal cells, which line the brain's ventricles and the central canal of the spinal cord. It can occur in both children and adults and may develop in different areas of the brain or spinal cord. Modern classification increasingly incorporates molecular characteristics and tumor location, in addition to microscopic features, to define different ependymoma types.

What is the Importance of Timely Treatment?

Timely diagnosis and treatment matter because an ependymoma can compress or infiltrate nearby brain or spinal cord structures and may obstruct normal cerebrospinal fluid (CSF) flow. Depending on its location and behaviour, the tumor can cause increased intracranial pressure, neurological impairment, hydrocephalus, or spinal cord dysfunction. Early specialist evaluation helps determine the appropriate treatment strategy.

What are the Common Symptoms of an Ependymoma?

  • Headache
  • Nausea and vomiting
  • Problems with balance or coordination
  • Difficulty walking
  • Seizures
  • Vision changes
  • Weakness or numbness
  • Back or neck pain in spinal tumors
  • Limb weakness or sensory changes
  • Changes in bladder or bowel function with spinal involvement
  • Hydrocephalus-related symptoms
  • Cognitive or behavioural changes in some brain tumors

Causes and Risk Factors of Ependymoma

Causes

  • The exact cause of most ependymomas is unknown. These tumors arise from genetic and molecular changes in ependymal cells, but in most patients there is no clearly identifiable environmental or lifestyle cause.
  • Some ependymomas have characteristic molecular alterations that help define their tumor subtype.

Risk Factors

  • Childhood or young age for certain ependymoma subtypes
  • Certain genetic conditions, particularly neurofibromatosis type 2 (NF2), which is associated with an increased risk of ependymal tumors
  • Specific molecular or genetic alterations within tumor cells.

Latest Research and Technologies in the Treatment of Ependymoma in Turkey

Ependymoma treatment is increasingly guided by molecular testing, tumour location, and the extent of safe surgical removal. Advanced MRI and molecular pathology help specialists classify the tumour and plan treatment. Surgery remains the main treatment, while modern radiation techniques, including intensity-modulated radiation therapy (IMRT) and proton therapy, may help limit radiation exposure to nearby healthy tissues in eligible patients. Research is also exploring new medicines and molecularly guided approaches for recurrent or difficult-to-treat ependymomas. Availability of specialised testing, proton therapy, and clinical trials varies between hospitals in Turkey and should be confirmed with the treating centre.

Treatment options for Ependymoma

Brain cancer surgery (craniotomy) : It is the primary treatment to diagnose, reduce the size of, or completely remove a brain tumor. The main goal is to safely remove as much of the tumor as possible while preserving vital brain functions like speech, movement, and cognitive abilities.


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Radiation Therapy : Radiation may be recommended after surgery for selected tumors, particularly when residual disease remains or when tumor characteristics indicate a higher risk of recurrence.

Chemotherapy : It has a limited role in many newly diagnosed ependymomas but may be considered in selected situations, particularly in children or recurrent disease when other treatment options are limited.


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Treatment for Recurrent Disease: Recurrent ependymoma may require additional surgery, radiation, systemic therapy or a combination of approaches depending on the location and previous treatments.

Multidisciplinary and Supportive Care: Neurology, neurosurgery, radiation oncology, pediatric oncology, rehabilitation and supportive-care specialists may work together to address tumor control, neurological function and quality of life.

  • Clinical assessment:
    • Medical history assessment: Evaluation begins with a detailed medical history and neurological examination. Doctors assess symptoms such as headaches, seizures, balance problems, weakness, sensory changes, walking difficulties and bladder or bowel dysfunction.
    • Developmental assessment in children: For children, doctors may also evaluate developmental progress, school performance, and changes in behaviour.
    • Pathological and molecular testing: Generally requires examination of tumour tissue obtained through surgery or biopsy. Pathological and molecular testing can help determine the ependymoma subtype and guide treatment planning.
    • CSF assessment: In selected patients, cerebrospinal fluid examination may be performed after imaging or surgery to evaluate possible tumor dissemination.
  • Imaging Tests:
    • MRI Brain: Provides detailed visualisation of intracranial ependymomas and their relationship with surrounding structures.
    • MRI Spine: Important for spinal ependymomas and for assessing possible dissemination through the CSF pathways.
    • Contrast-Enhanced MRI: Helps define tumor margins, enhancement patterns and residual or recurrent disease.
    • CT Scan: May be used in selected situations, particularly when MRI is unavailable or additional structural information is needed.
    • Spinal Imaging/Neuraxis MRI: May be performed to assess for tumor spread along the brain and spinal cord.

MediRehab (a chain of Rehab centres, part of MediGence) provides comprehensive tele-rehabilitation services designed to support Ependymoma patients in Turkey. These services include:

  • Physiotherapy: Helps improve strength, balance, coordination and mobility when the tumor or treatment has affected movement.
  • Occupational Therapy: Supports independence with daily activities and helps patients adapt to physical or neurological limitations.
  • Speech and Swallowing Therapy: May be recommended when a brain tumor or its treatment affects speech, communication or swallowing.
  • Neurorehabilitation: Structured rehabilitation can address motor, cognitive and functional difficulties following surgery or other neurological complications.
  • Long-Term Functional Support: Ongoing rehabilitation, nutritional support, psychological care and neurological follow-up may help patients manage persistent or changing functional needs.
  • Medicines do not usually eliminate a localised ependymoma but may be used to manage symptoms and treatment-related complications. Corticosteroids may be prescribed to reduce brain or spinal cord swelling around the tumor, while anti-seizure medicines may be used in patients who experience seizures. Pain medicines, anti-nausea medicines and other supportive treatments may also be required. Chemotherapy may be considered in selected recurrent or difficult-to-treat cases, particularly in pediatric patients, but its role varies according to tumor subtype and clinical circumstances.

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Hospitals for Ependymoma in Turkey

Medicana International Samsun Hospital: Top Doctors, and Reviews
Medicana International Samsun Hospital

Samsun, Turkey

Medicana International Samsun Hospital located in Samsun, Turkey is accredited by ISO, JCI. Also listed below are some of the most prominent infrastructural details:

  • International Samsun Hospital provides services in a closed area of 30.000 m2
  • 9 elevators with pressure control have been designed for you in the hospital with 3 blocks, two of which are 11 floors and the other 10 floors
  • Capacity of 249 beds
  • 7 Operating Theatres
  • 109 Intensive Care beds (19 Newborn, 7 Paediatric, 20 Coronary, 8 CVS, and 54 General)
  • Laboratories - Biochemistry, Pathology, Hormone, Microbiology, Sleep Lab
  • IVF Center
  • Oncology Center
  • The Hospital serves patients with a team of about 99 specialists and academicians in 40 branches and 631 employees
  • Medicana International Samsun uses advanced technology & modern equipment such as BT/MR 1.5 Tesla, 3d Conformal, Thermal Welding, Holmium Laser, 4D Ultrasonography, Color Doppler Ultrasonography, Mammography, and Radiotherapy; in order to perform safe, authentic and quick treatment
  • All kinds of rooms are available for the patients- Single, Suite and VIP Rooms. Patient rooms are equipped with the latest technology and comfort
  • Amenities provided in the room for patients and their relatives- TV and Minibar in each room, 24-hour interrupted Cafeteria service, central air-conditioning ventilation system in each room, Internet access, phones in rooms, and much more
  • Cafeteria/Restaurant
  • Pharmacies on Duty
  • Parking lot with a capacity for 50 vehicles
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Medicana International Istanbul: Top Doctors, and Reviews
Medicana International Istanbul

Istanbul, Turkey

Medicana International Istanbul located in Istanbul, Turkey is accredited by ISO, JCI. Also listed below are some of the most prominent infrastructural details:

  • Covers an indoor area of 30.000 m
  • Capacity of 191 beds
  • 34 ICUs
  • 8 NICUs
  • 8 Operation Theatres
  • Inpatient Floors
  • Outpatient Floors
  • Internal and Surgical Intensive Unit Care
  • Cardiovascular Surgery Intensive Care Unit
  • Coronary Intensive Care Unit
  • Neonatal Intensive Care Unit
  • Patient comfort CIP, VIP and Standard Patient Rooms
  • Intensive care patient rooms
  • Technology Advancement- PET-CT, ERCP, BT/MR 1.5 Tesla
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Medicana International Ankara Hospital: Top Doctors, and Reviews
Medicana International Ankara Hospital

Ankara, Turkey

Medicana International Ankara Hospital located in Ankara, Turkey is accredited by ISO, JCI. Also listed below are some of the most prominent infrastructural details:

  • Area of 20.000 m2
  • Capacity for 207 bed capacity
  • 8 Operating rooms
  • 26 Observation beds
  • 17 internal and surgical intensive care units
  • 9 cardiovascular intensive care units
  • 10 incubators
  • 5 Coronary Intensive Care Unit
  • Neonatal intensive care unit (NICU)
  • IVF Center
  • Advanced Oncology Unit
  • Bone Marrow Center
  • Organ Transplant Center
  • Cardiology center
  • Obesity Center
  • Clinical Services
  • In-house Pharmacies
  • Parking capacity of 50 vehicles and free valet service
  • Patients rooms are fully equipped and categorized as Suite room, VIP room and standard room
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Why Choose Turkey for Ependymoma Treatment?

  • Experienced Neuro-Oncology Teams: Patients can access multidisciplinary teams involving neurosurgeons, neuro-oncologists, radiation oncologists, neurologists and rehabilitation specialists.
  • Advanced Neuroimaging and Molecular Diagnosis: Major centres may offer high-resolution MRI, neuraxis imaging, advanced pathology and molecular testing to support tumor classification.
  • Advanced Neurosurgical Techniques: Selected patients may have access to image-guided and minimally invasive neurosurgical approaches designed to achieve maximal safe tumor removal.
  • Modern Radiation Therapy: Appropriate patients may have access to techniques such as IMRT, stereotactic radiation and proton therapy where available.
  • Comprehensive Rehabilitation and International Support: Rehabilitation services and international-patient departments can support recovery, follow-up and treatment coordination.

Frequently Asked Questions

Recovery depends on tumor location, size, extent of surgery, neurological effects and whether radiation or other treatment is required. Some patients recover within weeks, while others require several months of rehabilitation and follow-up.

Many patients can walk normally, particularly when the tumor does not affect motor pathways. Brain or spinal tumors that affect movement may cause weakness or balance problems and can require physiotherapy or other rehabilitation.

Major cancer and neurosurgical centres in Turkey may offer advanced MRI, image-guided neurosurgery, molecular pathology, and modern radiation techniques for appropriately selected patients.

Many major Turkish hospitals have international-patient departments that assist with medical records, specialist consultations, treatment coordination, travel arrangements, accommodation and follow-up care.

Look for a centre with neuro-oncology experience and access to neurosurgery, neuropathology, molecular testing, radiation oncology, and rehabilitation. For children, a multidisciplinary pediatric neuro-oncology team is particularly important.

Treatment outcomes depend on the tumour's location, molecular subtype, age at diagnosis, extent of safe surgical removal, and whether the disease has spread. Some tumours can be controlled for long periods, while others have a higher risk of recurrence. Ask the treating specialist about outcomes relevant to the specific tumor type and treatment plan.

Neurosurgeons, neuro-oncologists, radiation oncologists and pediatric oncology teams in Turkey manage ependymomas as part of specialised neuro-oncology care. Experience should be assessed according to the patient's age and specific tumor characteristics.

Risks depend on the tumor location and treatment. Surgery may cause bleeding, infection, seizures or neurological deficits, while radiation and medicines can cause treatment-specific side effects. The treating team should explain individual risks before therapy.

Consult a specialist neuro-oncology team to review the tumour's location, subtype and extent. Evaluation may include MRI of the brain and spine, surgical assessment, and pathological or molecular testing. The team can explain whether surgery, radiotherapy, observation or another treatment approach is appropriate. Sudden severe headache, repeated vomiting, new weakness, seizures or reduced consciousness require urgent medical assessment.

Yes. Depending on its location and the effects of treatment, an ependymoma may cause lasting weakness, balance difficulties, sensory changes, or bladder and bowel dysfunction. However, these problems do not occur in every patient. Rehabilitation and long-term follow-up can help manage persistent symptoms and support daily functioning.

Yes. Symptoms, neurological deficits, treatment effects and the need for long-term monitoring can affect mobility, education, work, communication, independence, and emotional well-being. Rehabilitation and supportive care can help address these challenges.

An untreated ependymoma may continue to grow and compress or damage nearby neurological structures. Depending on its location and behaviour, it can cause progressive neurological impairment, hydrocephalus, seizures or other complications.

Most ependymomas cannot be prevented because their exact causes are not known. People with certain inherited conditions associated with increased tumor risk may require specialist surveillance according to their genetic and clinical circumstances.

Ependymoma can occur at any age but has different patterns across age groups and molecular subtypes. Some forms are more frequently seen in children, while spinal ependymomas are more common in adults. Certain inherited conditions are also associated with an increased risk of ependymal tumors.

Author

Nimra Haseeb
Nimra Haseeb

MSc Biochemistry

4 Years of Experience

Miss Nimra Haseeb is a medical researcher and a scientific content writer. She holds a Bachelor’s degree in Biotechnology and a Master’s in Biochemistry from Integral University, Lucknow. With strong experience in healthcare research, she specializes in secondary research, clinical data analysis, and evidence-based medical writing. Her work focuses on transforming complex scientific and medical information into clear, accurate, and reliable healthcare content for patients and healthcare audiences. She is also experienced in interpreting medical studies and healthcare trends to deliver well-researched and informative content that supports better health awareness and decision-making. View More

Reviewer

Dr. Mohit Agarwal
Dr. Mohit Agarwal

Medical Oncologist

14 Years of Experience

One of the finest Oncologist in New Delhi, India, Dr. Mohit Agarwal has worked with several world class multidisciplinary hospitals over the years. Dr. Mohit Agarwal has over 14+ years of experience in his field. The doctor treats and manages a wide range of conditions such as Stomach Cancer, Rectal Cancer, Breast Cancer, Brain Cancer View More

Last Reviewed - January 2026