Dr. Peter Barrett Lee

Dr. Peter Barrett Lee

Cancer Specialist - Radiation Oncologist,Medical Oncologist,Surgical Oncologist

  Rutherford Cancer Center, South Wales, London, United Kingdom

  35 Years of experience

BIOGRAPHY

Dr. Peter Barrett Lee is one of the finest Cancer Specialist in United Kingdom. He is an experienced Medical Oncologist in the United Kingdom. The Medical practitioner has been associated with various reputed hospitals in the United Kingdom. The physician is currently working as a Consultant Clinical Oncologist, Rutherford Cancer Center, South Wales, United Kingdom. The doctor is a well-reputed and sought after medical expert and is

  • Doctorate of Medicine

qualified. Dr. Peter Barrett Lee has been associated with many hospitals over the course of his illustrious and experienced career.

The hospitals include:

  • Professor Peter Barrett Lee was Medical Registrar at Mayday Hospital, Croydon and gained Membership of the Royal College of Physicians in 1985. He gained his Doctorate of Medicine Thesis in the laboratory of the Medical Breast unit at St Georges Hospital, London under the supervision of Professor R Charles Coombes. He then worked at the Meyerstein Institute of Clinical Oncology at UCL Hospitals London on several clinical trials of new hormones and chemotherapy that have now become standard treatments

Dr. Peter Barrett Lee has more than 35 Years of clinic experience. The Clinician specializes in and performs the following surgeries:

  • Breast Cancer Treatment
  • Chemotherapy
  • Intensity-modulated radiotherapy (IMRT)
  • Skin Cancer Treatment
  • Stereotactic Radio Therapy (SRT)
  • Oncology
CERTIFICATIONS (1)
  • He trained for 5 years in both radiotherapy and medical oncology at the Royal Marsden Hospital and obtained the Fellowship of the Royal College of Radiologists.
MEMBERSHIPS (3)
  • Fellow Royal College of Radiologists
  • Fellow of Royal College of Physicians of London
  • Fellow of Royal College of Physicians of Edinburgh
Procedures
Breast Cancer Treatment

The recent advances made in breast cancer treatment have revolutionized the way how women from this rare disorder are diagnosed and suggested a personalized treatment plan. These advances have made it easier for the doctors to arrive at a treatment plan, which is most suitable for the patient as per their individual characteristics and needs.

Different breast cancer treatment options help destruct complex mixture of cancer cells, which are otherwise difficult to treat using conventional breast cancer treatment. The treatment is started by the doctors handling the case as soon as the breast cancer diagnosis is confirmed.

Before the article delves into the different breast cancer treatment options, lets first take a look at how breast cancer develops and what are its symptoms and diagnosis methods.

Breast cancer: What do the statistics say?

Breast cancer primarily affects females aged above 40. However, that does not mean that it does not affect women aged below 40. Breast cancer can also affect males, although rarely.

Breast cancer starts in the cells of either one or both the breasts. It accounts for more than 16 percent of female cancer and contributes to 18.2 percent of all deaths that take place around the world because of cancer.

In the US alone, breast cancer affects more than 232,000 females and 2,200 males each year. It leads to death of more than 39,000 breast cancer patients in a year.

Breast Cancer Symptoms

The symptoms of breast cancer can be easily identified at home through breast self-examination. You should consult your physician on how to conduct this exam at home.

The most common breast cancer symptoms include:

  • Change in the size or shape of the breast
  • Lump in the breast
  • Swelling in armpit
  • Change in colour and shape of the nipples
  • Rash, redness or pitting on the breast skink
  • Pain in the breast or armpits
  • Abnormal discharge from the nipples

In case of more aggressive breast cancer called inflammatory breast cancer, severe redness and itching may be present.

The patients are advised to contact their physician as soon as they notice any of the symptoms of breast cancer. The physician is the best person to diagnose whether it is normal or inflammatory best cancer, and accordingly, suggest treatment for breast cancer.

Breast Cancer Causes

The exact reason that causes breast cancer is unclear, despite the fact that every eighth woman suffers from it. However, there are several factors that have been associated with the development of breast cancer. Some of the breast cancer risk factors include:

  • Prolonged use of birth control pills
  • Obesity
  • Use of hormone replacement therapy
  • High breast density
  • Alcohol addiction
  • No history of pregnancy
  • Pregnancy after 35
  • Exposure to radiation

The risk of breast cancer naturally increases as women age. The risk is also higher in women who have a family history of breast or ovarian cancer, possess BRCA1 and BRCA2 genes or who have had their periods before the age of 12.

Chemotherapy

Chemotherapy is a category of standardized drug administration of various types for the treatment of cancer. With a curative intent, some combinations of drugs are administered to a patient to prolong their life and also to bring about a reduction in the symptoms shown by the patient. Chemotherapy treatment is considered to be one of the major categories of medical oncology. Many people around the world are prescribed to undergo chemotherapy treatment instead of undergoing a surgical procedure. But many are frightened with the side effects of this treatment as it is believed to reduce the quality of life of the patients.

What is chemotherapy?

Chemotherapy is a procedure where non-specific intracellular poisons are used, which are specifically related to preventing the process of mitosis or the natural cell division of the cancerous cells. This technique rather excludes those agents that are responsible for selective extracellular growth signal blockade (signal transduction blockers). If spoken about these agents used in chemotherapy, it has been found that most of them are cytotoxic in nature due to their property of interfering with natural mitosis. However, the cells of cancer can differ widely in terms of showing susceptibility to these administered agents.

Chemotherapy can be defined as a way of mass destruction of stress cells, which would eventually lead to the death of the cells when apoptosis is initiated. The commonly known side effects of chemotherapy can be traced back to the process of damaging normal non-cancerous cells, which are in the process of rapid division. They are sensitive to anti-mitotic drugs that are being administered to the patient and such cells may include the cells of the hair follicles, digestive tract lining, and bone marrow. But nowadays treatment options have undergone a lot of modification by which these side effects can be well countered.

Types of Chemotherapy Drugs

Various options of drugs are available to treat different types of cancer including the following:

Alkylating agents: These kinds of agents prove to be extremely beneficial during the cell’s resting phase. The various kinds of alkylating agents that are employed in chemotherapy treatment include the following:

  • Mustard gas derivatives: Cyclophosphamide, mechlorethamine, chlorambucil, ifosfamide, melphalan
  • Ethylenimines: Thiotepa and hexamethylmelamine
  • Alkylsulfonates: Busulfan
  • Metal salts: Oxaliplatin, cisplatin, and carboplatin
  • Nitrosoureas: Streptozocin, lomustine, carmustine

Nitrosoureas are unique from the rest for choices in chemotherapy treatment due to their ability to cross the blood-brain barrier and treating tumors of the brain.

Plant alkaloids: Plant alkaloids employed for chemotherapy treatment are derived from plants.  These include vinca alkaloids, taxanes, podophyllotoxins, and camptothecan analogs. The plant alkaloids are cell cycle specific agents, which enables them to attack the dividing cells in various stages of their division cycle.

Antimetabolites: This kind of chemotherapy treatment involves substances that are similar in composition to the normal substances present in the cell. When these substances get incorporated in the process of cellular metabolism, then the cell is no longer able to divide. They are also cell cycle specific and can be classified further according to the substance in the cell with which they interfere.

Topoisomerase inhibitors: When the topoisomerase enzymes in the body ( topoisomerase I and II) are inhibited as a result of chemotherapy drugs, then those drugs are referred to as topoisomerase inhibitors. During the chemotherapy, the topoisomerase enzymes are responsible for controlling structural manipulation of the DNA which is necessary for the purpose of replication.

Miscellaneous antineoplastics: Different types of drugs make each chemotherapy treatment process unique. Enzymes, retinoids, adrenocortical steroid inhibitor, ribonucleotide reductase inhibitor or antimicrotubule agents can be used as chemotherapy drugs.

Intensity-modulated radiotherapy (IMRT)

Intensity-modulated radiotherapy (IMRT) is a type of conformal radiotherapy, a technology that enables the radiation oncologist to precisely target the tissues with cancer cells. . In this type of radiation therapy for cancer, the radiation beams closely take up the shape of the area that is being targeted.

IMRT is delivered through the standard radiotherapy machine, which is also known as the linear accelerator (LINAC). This machine has a device called multileaf collimator, which possesses lead leaves that can move independently to form a shape that best fits the target area.

Because the radiation beams can take up the shape of the target area, high dosage of radiation can be delivered to kill the cancer cells while minimizing exposure to the non-cancerous cells and tissues. IMRT proves to be highly effective in the case of head and neck cancer among other types of cancer.IMRT for prostate cancer is now available across all major hospitals around the world.

The efficiency of IMRT has already been tested for multiple cancers, including breast cancer. Latest advancements improving the efficacy of radiotherapy, however, continue to take place in the field of healthcare. This radiation treatment for cancer is already being used as a standard treatment for some cancer types.

Skin Cancer Treatment

Skin cancer is the most common type of cancer. It typically affects people with lighter skin tone. Skin cancer is the uncontrolled and abnormal growth of destructive malignant skin cells. It occurs when unrepairable DNA damage that occurs in the skin cells triggers a mutation that makes them multiply rapidly and form malignant skin tumors.

Skin cancer is mostly caused by ultraviolet radiation from sunshine or tanning beds. Skin cancers have a limited potential to spread to other parts of the body and may become life-threatening if not treated on time. They are common and can be effectively treated but the treatment of some forms of skin cancers can be difficult. However, early diagnosis and treatment can increase the survival rate.

Types of Skin Cancer

The following are the three common types of skin cancers:

  • Basal cell skin cancer: This type of skin cancer is present in sun-exposed areas of the skin. Basal cell skin cancer rarely spread to other body parts (metastasize) and do not cause death. They are very common and easily treatable.
  • Squamous cell skin cancer: These skin cancers are also common but less common than basal cell cancers. They can metastasize but the metastasis rate is very low. They are also non-life threatening and can be treated easily.
  • Melanoma: This type of skin cancer originates from the pigment that gives color to the skin called melanocyte. It is less common and more dangerous than the first two types of skin cancer. However, if melanoma is recognized and treated early, it is almost curable. Advanced stage melanoma can spread to other parts of the body and is hard to treat. It can be life-threatening as well.

There are also some other types of skin cancers such as Merkel cell skin cancer, Kaposi sarcoma skin cancer and lymphoma of the skin, but these are rare. Although, some of these are aggressive skin cancers and has a high risk of recurrence.

Skin Cancer: Symptoms

The typical skin cancer symptoms vary from patient to patient. The symptoms also vary depending on the type of skin cancer that the patient has.

However, basal and squamous skin cancers can have some common symptoms, which include:

  • Flat, firm, pale or yellow areas, similar to scars
  • Raised reddish patches that might be itchy without pain
  • Small, pink or red, shiny, translucent, pearly bumps, which may have blue, brown or black areas
  • Raised growth and lumps with a lower area in their center, which might contain abnormal blood vessels spreading out
  • Open sores that do not heal, or come back after healing
  • Rough or scaly red patches, which may crust or bleed

Melanoma skin cancer can have some different types of skin cancer symptoms. There is an ABCDE rule guide that explains the melanoma symptoms:

  • A is for Asymmetry: One half of a mole or birthmark that does not match the other half.
  • B is for Border: The edges are ragged, irregular, notched, or blurred.
  • C is for Color: The color is not the same throughout the mole and may include different shades and patches of brown or black, pink, red, white, or blue.
  • D is for Diameter: The spot or skin growth is larger than 6 millimeters across, although melanomas can sometimes be smaller than this.
  • E is for Evolving: There is a change in size, shape, color, or surface of the mole.
Stereotactic Radio Therapy (SRT)

Stereotactic radiotherapy (SRT) is a type of technique used to precisely target radiation beams at the tumour. This is one of the latest innovations in the field of radiation therapy. Since this treatment requires special equipment, machine, and expertise, this treatment is not widely available across all cancer treatment hospitals.

SRT involves treatment of a tumour with the help of a special machine known as a linear accelerator (LINAC). This machine is used to deliver external radiation therapy in the case of normal radiation therapy and intensity-modulated radiation therapy (IMRT).

SRT treatment involves of small daily doses of radiation, which are also known as fractions. The patient may be advised to undergo anywhere between 3 to 30 fractions in a day, depending on the extent of cancer and the size of the area that is being targeted. SRT is mostly used for the treatment of smaller lesions and tumours and is less than 3 cms in size.

Stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) are types of SRT. SRS is also known as Gamma Knife surgery. It involves exposing the tumour to a very high dose of radiation in one to five fractions. Gamma Knife surgery is usually used for the treatment of a tumour in the central nervous system (CNS).

On the other hand, SBRT is a special procedure used for the treatment of tumours located outside the central nervous system. In this approach, radiation is delivered through different directions or positions of the body. It can be used for the treatment of small tumours in the lungs, pelvis, prostate, pancreas and other organs as well.

SRT is mostly used for the treatment of the following conditions:

  • Secondary brain tumours
  • Small lesion or brain tumour that has a well-defined edge
  • Glioma that may have returned after months or years of treatment

Gamma Knife surgery is different from CyberKnife radiation. The latter is used for the treatment of cancerous and non-cancerous tumours as well as other medical conditions. CyberKnife treatment is actually a frameless robotic radiosurgery system that delivers a high dose of radiation to the targeted location.

Frequently Asked Questions
What area of specialization does Dr. Peter Barrett Lee have?
Dr. Peter Barrett Lee is specialized in United Kingdom and of the most sought after doctors in Cancer Specialist.
Does Dr. Peter Barrett Lee offer Telemedicine Consultation through Medigence?
No, this doctor dose not offer telemedicine via MediGence
How many years of experience does Dr. Peter Barrett Lee have?
Dr. Peter Barrett Lee is one of the most sought after specialists in United Kingdom and has over 35 Years years of experience.
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