Dr. Mutlu Demiray

Dr. Mutlu Demiray

Cancer Specialist - Medical Oncologist

  Medicana Konya, Konya, Turkey

  20 Years of experience


Qualification and Experience

Dr. Mutlu Demiray is an experienced oncologist in Istanbul. Dr. Demiray has a clinical experience of more than 15 years and has been in medical oncology for many years. He has currently providing his esteemed services at Medicana International Hospital, Istanbul in Medical Oncology department as Professor of Medicine. Dr. Demiray has been associated with various hospitals during his illustrious career such as Uluda? University School of Medicine, Internal Medicine and Medical Oncology Residency Program, Ruhr Hospital hyperthermia and Integrative oncology education Medical Park Hospital, Bursa Istanbul Italian Oncology Hospital, Bursa AOS Oncology Hospital, Ortado?u Hospital Medicana International Hospital, Istanbul, Medical Oncology Department. Dr. Demiray completed his graduation in the year 2005 from Uluda? University Cerrahpa?a School of Medicine. Later, in the year 2005, he undergone residency program in Internal Medicine and Medical Oncology at Uluda? University School of Medicine.

Contribution to Medical Science

Dr. Mutlu Demiray is a research-oriented oncologist who has interest and passion for developing novel formulation to treat patients. In the year 2006, received Associate Professor degree and in 2016 he obtained Professor degree. He had comprehensively studied the relation between Helicobacter pylori and gastric cancer. His area of service includes prostate cancer, stomach cancer, thyroid cancer, Colo-rectal cancer, esophageal cancer, lung cancer, sarcomas, lymphomas, liver cancer, gynecological tumors, breast cancer, head and head tumors and other oncology disorders. As a Chief Physician in the Department of Oncology at Medicana International Hospital, he has extensive experience in managing cancer through chemotherapy, immunotherapy, and radiotherapy. Several articled of Dr. Demiray have been published in various journal with high impact factor. Dr. Demiray, along with his colleagues, have developed an oral nano-formulation of curcumin with high bioavailability. He is a Professional Member of American Botanical Council.

Past Experience

  • Medicine and Medical Oncology Residency Program
  • Bursa AOS Oncology Hospital
  • Medical Park Hospital, Bursa
  • Istanbul Italian Oncology Hospital
  • Ortadogu Hospital
  • Ruhr Hospital hyperthermia and Integrative oncology education
  • Medicana International Hospital, Istanbul, Medical Oncology Department


  • Uludag University Cerrahpaşa School of Medicine(2000)
  • Postgraduate Education (Residency) Uludag University School of Medicine, Internal
  • Medicine and Medical Oncology Residency Program (2005)
  • A cross-sectional survey of the diagnosis and management of bone metastasis in breast cancer patients in Turkey.
  • Phase II Study Of Gemcitabine Plus Paclitaxel In Metastatic Breast Cancer Patients With Prior Anthracycline Exposure.
  • Evaluation of the effects of Helicobacter pylori eradication therapy on gastric antral epithelial hyperproliferation: a prospective six-month follow-up study.

Chemotherapy is a category of standardized drug administration of various types for the treatment of cancer. With a curative intent, some combinations of drugs are administered to a patient to prolong their life and also to bring about a reduction in the symptoms shown by the patient. Chemotherapy treatment is considered to be one of the major categories of medical oncology. Many people around the world are prescribed to undergo chemotherapy treatment instead of undergoing a surgical procedure. But many are frightened with the side effects of this treatment as it is believed to reduce the quality of life of the patients.

What is chemotherapy?

Chemotherapy is a procedure where non-specific intracellular poisons are used, which are specifically related to preventing the process of mitosis or the natural cell division of the cancerous cells. This technique rather excludes those agents that are responsible for selective extracellular growth signal blockade (signal transduction blockers). If spoken about these agents used in chemotherapy, it has been found that most of them are cytotoxic in nature due to their property of interfering with natural mitosis. However, the cells of cancer can differ widely in terms of showing susceptibility to these administered agents.

Chemotherapy can be defined as a way of mass destruction of stress cells, which would eventually lead to the death of the cells when apoptosis is initiated. The commonly known side effects of chemotherapy can be traced back to the process of damaging normal non-cancerous cells, which are in the process of rapid division. They are sensitive to anti-mitotic drugs that are being administered to the patient and such cells may include the cells of the hair follicles, digestive tract lining, and bone marrow. But nowadays treatment options have undergone a lot of modification by which these side effects can be well countered.

Types of Chemotherapy Drugs

Various options of drugs are available to treat different types of cancer including the following:

Alkylating agents: These kinds of agents prove to be extremely beneficial during the cell’s resting phase. The various kinds of alkylating agents that are employed in chemotherapy treatment include the following:

  • Mustard gas derivatives: Cyclophosphamide, mechlorethamine, chlorambucil, ifosfamide, melphalan
  • Ethylenimines: Thiotepa and hexamethylmelamine
  • Alkylsulfonates: Busulfan
  • Metal salts: Oxaliplatin, cisplatin, and carboplatin
  • Nitrosoureas: Streptozocin, lomustine, carmustine

Nitrosoureas are unique from the rest for choices in chemotherapy treatment due to their ability to cross the blood-brain barrier and treating tumors of the brain.

Plant alkaloids: Plant alkaloids employed for chemotherapy treatment are derived from plants.  These include vinca alkaloids, taxanes, podophyllotoxins, and camptothecan analogs. The plant alkaloids are cell cycle specific agents, which enables them to attack the dividing cells in various stages of their division cycle.

Antimetabolites: This kind of chemotherapy treatment involves substances that are similar in composition to the normal substances present in the cell. When these substances get incorporated in the process of cellular metabolism, then the cell is no longer able to divide. They are also cell cycle specific and can be classified further according to the substance in the cell with which they interfere.

Topoisomerase inhibitors: When the topoisomerase enzymes in the body ( topoisomerase I and II) are inhibited as a result of chemotherapy drugs, then those drugs are referred to as topoisomerase inhibitors. During the chemotherapy, the topoisomerase enzymes are responsible for controlling structural manipulation of the DNA which is necessary for the purpose of replication.

Miscellaneous antineoplastics: Different types of drugs make each chemotherapy treatment process unique. Enzymes, retinoids, adrenocortical steroid inhibitor, ribonucleotide reductase inhibitor or antimicrotubule agents can be used as chemotherapy drugs.

Frequently Asked Questions
What area of specialization does Dr. Mutlu Demiray have?
Dr. Mutlu Demiray is specialized in Turkey and of the most sought after doctors in Cancer Specialist.
Does Dr. Mutlu Demiray offer Telemedicine Consultation through Medigence?
No, this doctor dose not offer telemedicine via MediGence
How many years of experience does Dr. Mutlu Demiray have?
Dr. Mutlu Demiray is one of the most sought after specialists in Turkey and has over 20 Years years of experience.
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