Dr. Kuraparthy Sambasivaiah

Dr. Kuraparthy Sambasivaiah

Cancer Specialist - Medical Oncologist,Surgical Oncologist

  Star Hospitals, Hyderabad, India

BIOGRAPHY

Dr. Kuraparthy Sambasivaiah is one of the finest Cancer Specialist in India. He is an experienced Medical Oncologist in the India. The Medical practitioner has been associated with various reputed hospitals in the India. The physician is currently working as a Oncologist, Star Hospitals, India. The doctor is a well-reputed and sought after medical expert and is

  • MBBS – Sri Venkateswara Medical College, Tirupati
  • MD, Internal Medicine – All India Institute of Medical Sciences (AIIMS), New Delhi

qualified. Dr. Kuraparthy Sambasivaiah has been associated with many hospitals over the course of his illustrious and experienced career.

The hospitals include:

  • He founded and developed medical oncology department at Sri Venkateswara Institute of Medical Sciences (SVIMS), Tirupati, and trained students in medical oncology. He was a professor of medical oncology.

Dr. Kuraparthy Sambasivaiah has more than of clinic experience. The Clinician specializes in and performs the following surgeries:

  • Breast Cancer Treatment
  • Chemotherapy
  • Lung Cancer Treatment
  • Stomach Cancer Treatment
  • Oncology
CERTIFICATIONS (4)
  • Certification in DM (Medical Oncology) – Cancer Institute, Adyar – Chennai
  • Fellowship / Additional Training at ICRETT, International Centre for Cancer Immunotherapy and Cell Therapies, Tel Aviv – Israel
  • Fellowship / Additional Training at IARC, Cancer Epidemiology
  • Visiting Clinician Program in BMT, Mayo Clinic, USA
RESEARCH PAPERS AND PUBLICATIONS (1)
  • He had published several important original research papers, especially on Breast, Lung and Stomach cancers
Procedures
Breast Cancer Treatment

The recent advances made in breast cancer treatment have revolutionized the way how women from this rare disorder are diagnosed and suggested a personalized treatment plan. These advances have made it easier for the doctors to arrive at a treatment plan, which is most suitable for the patient as per their individual characteristics and needs.

Different breast cancer treatment options help destruct complex mixture of cancer cells, which are otherwise difficult to treat using conventional breast cancer treatment. The treatment is started by the doctors handling the case as soon as the breast cancer diagnosis is confirmed.

Before the article delves into the different breast cancer treatment options, lets first take a look at how breast cancer develops and what are its symptoms and diagnosis methods.

Breast cancer: What do the statistics say?

Breast cancer primarily affects females aged above 40. However, that does not mean that it does not affect women aged below 40. Breast cancer can also affect males, although rarely.

Breast cancer starts in the cells of either one or both the breasts. It accounts for more than 16 percent of female cancer and contributes to 18.2 percent of all deaths that take place around the world because of cancer.

In the US alone, breast cancer affects more than 232,000 females and 2,200 males each year. It leads to death of more than 39,000 breast cancer patients in a year.

Breast Cancer Symptoms

The symptoms of breast cancer can be easily identified at home through breast self-examination. You should consult your physician on how to conduct this exam at home.

The most common breast cancer symptoms include:

  • Change in the size or shape of the breast
  • Lump in the breast
  • Swelling in armpit
  • Change in colour and shape of the nipples
  • Rash, redness or pitting on the breast skink
  • Pain in the breast or armpits
  • Abnormal discharge from the nipples

In case of more aggressive breast cancer called inflammatory breast cancer, severe redness and itching may be present.

The patients are advised to contact their physician as soon as they notice any of the symptoms of breast cancer. The physician is the best person to diagnose whether it is normal or inflammatory best cancer, and accordingly, suggest treatment for breast cancer.

Breast Cancer Causes

The exact reason that causes breast cancer is unclear, despite the fact that every eighth woman suffers from it. However, there are several factors that have been associated with the development of breast cancer. Some of the breast cancer risk factors include:

  • Prolonged use of birth control pills
  • Obesity
  • Use of hormone replacement therapy
  • High breast density
  • Alcohol addiction
  • No history of pregnancy
  • Pregnancy after 35
  • Exposure to radiation

The risk of breast cancer naturally increases as women age. The risk is also higher in women who have a family history of breast or ovarian cancer, possess BRCA1 and BRCA2 genes or who have had their periods before the age of 12.

Chemotherapy

Chemotherapy is a category of standardized drug administration of various types for the treatment of cancer. With a curative intent, some combinations of drugs are administered to a patient to prolong their life and also to bring about a reduction in the symptoms shown by the patient. Chemotherapy treatment is considered to be one of the major categories of medical oncology. Many people around the world are prescribed to undergo chemotherapy treatment instead of undergoing a surgical procedure. But many are frightened with the side effects of this treatment as it is believed to reduce the quality of life of the patients.

What is chemotherapy?

Chemotherapy is a procedure where non-specific intracellular poisons are used, which are specifically related to preventing the process of mitosis or the natural cell division of the cancerous cells. This technique rather excludes those agents that are responsible for selective extracellular growth signal blockade (signal transduction blockers). If spoken about these agents used in chemotherapy, it has been found that most of them are cytotoxic in nature due to their property of interfering with natural mitosis. However, the cells of cancer can differ widely in terms of showing susceptibility to these administered agents.

Chemotherapy can be defined as a way of mass destruction of stress cells, which would eventually lead to the death of the cells when apoptosis is initiated. The commonly known side effects of chemotherapy can be traced back to the process of damaging normal non-cancerous cells, which are in the process of rapid division. They are sensitive to anti-mitotic drugs that are being administered to the patient and such cells may include the cells of the hair follicles, digestive tract lining, and bone marrow. But nowadays treatment options have undergone a lot of modification by which these side effects can be well countered.

Types of Chemotherapy Drugs

Various options of drugs are available to treat different types of cancer including the following:

Alkylating agents: These kinds of agents prove to be extremely beneficial during the cell’s resting phase. The various kinds of alkylating agents that are employed in chemotherapy treatment include the following:

  • Mustard gas derivatives: Cyclophosphamide, mechlorethamine, chlorambucil, ifosfamide, melphalan
  • Ethylenimines: Thiotepa and hexamethylmelamine
  • Alkylsulfonates: Busulfan
  • Metal salts: Oxaliplatin, cisplatin, and carboplatin
  • Nitrosoureas: Streptozocin, lomustine, carmustine

Nitrosoureas are unique from the rest for choices in chemotherapy treatment due to their ability to cross the blood-brain barrier and treating tumors of the brain.

Plant alkaloids: Plant alkaloids employed for chemotherapy treatment are derived from plants.  These include vinca alkaloids, taxanes, podophyllotoxins, and camptothecan analogs. The plant alkaloids are cell cycle specific agents, which enables them to attack the dividing cells in various stages of their division cycle.

Antimetabolites: This kind of chemotherapy treatment involves substances that are similar in composition to the normal substances present in the cell. When these substances get incorporated in the process of cellular metabolism, then the cell is no longer able to divide. They are also cell cycle specific and can be classified further according to the substance in the cell with which they interfere.

Topoisomerase inhibitors: When the topoisomerase enzymes in the body ( topoisomerase I and II) are inhibited as a result of chemotherapy drugs, then those drugs are referred to as topoisomerase inhibitors. During the chemotherapy, the topoisomerase enzymes are responsible for controlling structural manipulation of the DNA which is necessary for the purpose of replication.

Miscellaneous antineoplastics: Different types of drugs make each chemotherapy treatment process unique. Enzymes, retinoids, adrenocortical steroid inhibitor, ribonucleotide reductase inhibitor or antimicrotubule agents can be used as chemotherapy drugs.

Lung Cancer Treatment

Lung cancer is an uncontrolled growth of cells that start off in the lungs. Usually, lung cancer starts in the cells that line the air passages. Instead of developing into healthy lung tissue, the cells divide rapidly and form tumours.

Lung cancer can grow and spread beyond the lung to reach other parts of the body through metastasis. Lung cancers can begin in any part of the lung, but 90 percent of lung cancers begin in the epithelial cells, which are the cells lining the larger and smaller airways also known as bronchi and bronchioles.

This is the reason why lung cancers are sometimes called bronchogenic cancers or bronchogenic carcinomas. Lung cancer is the most common cancer in the world, among both men and women. It is the leading cause of cancer deaths worldwide.

Lung Cancer: Causes and Risk Factors

Long-term smoking is the main cause of lung cancer. After smoking, genetic factors and exposure to radon gas, asbestos, second-hand smoke or other forms of air pollution can also increase the risk of lung cancer.

Types of Lung Cancer

There are two major types of lung cancers, based on the appearance of lung cancer cells under the microscope:

  • Non-small cell lung cancer (NSCLC): It is an umbrella term for several types of lung cancers that behave in a similar way, such as squamous cell carcinoma, adenocarcinoma, and large cell carcinoma.
  • Small cell lung cancer (SCLC): This type of lung cancer occurs mostly in heavy smokers and it is less common than non-small cell lung cancer. 

Lung Cancer Stages

It is necessary to determine the stage of lung cancer by finding out how far cancer has spread, before initiating treatment of lung cancer.
The following are the four lung cancer stages of NSCLC:

  • Stage 1 lung cancer: Cancer is restricted to the lung
  • Stage 2 lung cancer: Cancer has spread to the nearby lymph nodes
  • Stage 3 lung cancer: (3a) Cancer is in the lung and the lymph nodes located on the same side  (3b) Cancer is in the lung and has spread to lymph nodes on the opposite side
  • Stage 4 lung cancer: Cancer has spread to both the lungs and other organs and surrounding tissues

The following are the two lung cancer stages of SCLC:

  • Limited stage: Cancer is present in just one lung and lymph nodes on the same side of cancer.
  • Extensive stage: Cancer has spread throughout the lung or both the lungs, to the lymph nodes on the opposite side, to the bone marrow, and to the distant organs.

After the determination of stage, treatment of lung cancer starts with choosing the best suitable option for the patient. However, there is usually no single treatment for lung cancer. So the patient often receives a combination of therapies and palliative care. 

Lung Cancer Symptoms

Lung cancer symptoms may vary, depending upon where and how widespread the tumour is. A person with lung cancer may have following lung cancer symptoms:

  • A persistent or chronic coughing
  • Pain in chest, shoulder or back
  • Difficulty in breathing and shortness of breath
  • Hoarseness or change of voice
  • Chronic bronchitis, pneumonia or respiratory infections
  • Blood in the sputum and cough


Stage 3 lung cancer symptoms include the following:

  • Wheezing
  • General pain in the chest or when breathing
  • Persistent cough with or without blood
  • Altered voice
  • Loss of appetite
  • Unplanned weight loss
  • Fever, headache, weakness, and bone pain
  • Difficulty swallowing
Stomach Cancer Treatment

Stomach cancer, also known as gastric cancer, is the fifth most common cancer worldwide. This disease is a result of the growth of cancerous and malignant cells in the inner lining of the stomach.

Stomach cancer does not grow overnight as this disease usually grows slowly over many years. Some pre-cancerous changes take place before true cancer actually develops. But these early changes rarely result in any symptoms and therefore, often go undetected in the early stage when it is most easy to treat it.

Gastric cancer can grow through the wall of the stomach and invade nearby organs. It can easily spread to the lymph vessels and lymph nodes. In an advanced stage, it can travel through the bloodstream and spread or metastasize to organs such as the liver, lungs, and bones. Usually, people diagnosed with stomach cancer have either experienced metastasis already or eventually develop it.

Types of Stomach Cancer

Stomach cancer should not be confused with other cancers in the abdomen or esophageal cancer. Some other cancer can also occur in the abdomen, including cancer of the large and small intestine, liver or pancreas. These cancers may have different symptoms, outlook, and options for treatment.

Some of the common types of gastric cancer include:

  • Adenocarcinoma: It is the most common form of stomach cancer and about 90 to 95 percent of stomach cancers are This form of cancer develops from the cells that form the innermost lining (mucosa) of the stomach.
  • Lymphoma: This is a rare form of stomach cancer and only about four percent of stomach cancers are lymphomas. These are cancers of the immune system tissue, sometimes found in the wall of the stomach.
  • Gastrointestinal stromal tumor (GIST): It is a rare kind of tumor that starts in very early forms of cells in the wall of the stomach calledinterstitial cells of Cajal. GISTs can be found anywhere in the digestive tract.
  • Carcinoid tumour: It is also a rare form of stomach cancer and about three percent of stomach cancers are carcinoid tumors. Carcinoid tumors start in cells of the stomach that produced hormones.

Some other types of stomach cancers include squamous and small cell carcinoma and leiomyosarcoma. These cancers are very rare.

Stomach Cancer Causes

There is no single, definite cause behind stomach cancer. However, several stomach cancer risk factors have been identified that could potentially lead to the formation to a tumor in the stomach. Some of these stomach cancer causes or risk factors include:

  • Inflammation of the gut called gastritis
  • Infection with common bacteria called Helicobacter pylori
  • Long-lasting anaemia
  • Growth in stomach called polyps
  • Smoking
  • Obesity
  • Excessive consumption of smoked, pickled or salty foods
  • A-type blood group
  • Epstein-Barr virus infection
  • Certain genes (family history of disease)

Stomach Cancer Symptoms

There can be several early stomach cancer symptoms. However, the signs of stomach cancer could be present because of some other underlying condition as well. Unfortunately, this is the main reason why it is difficult to make stomach cancer diagnosis at an early stage.

Some of the early stomach cancer symptoms may include:

  • Heartburn
  • Regular indigestion
  • Slight nausea
  • Loss of appetite
  • Frequent burping
  • Feeling bloated

But just experiencing indigestion or heartburn after a meal does not really mean that you have cancer. Although, if you experience these symptoms a lot, talk to your doctor, who can decide whether to conduct further tests or not.

As advanced gastric cancer grow, you may experience more serious signs of stomach cancer, including the following:

  • Frequent stomach ache or pain in the sternum
  • Frequent heartburns
  • Vomiting containing blood
  • Dysphagia (swallowing difficulties)
  • Loss of appetite, accompanied by sudden weight loss
  • Blood in stools
  • Excessive fatigue
  • Yellowish eyes or skin
Frequently Asked Questions
What area of specialization does Dr. Kuraparthy Sambasivaiah have?
Dr. Kuraparthy Sambasivaiah is specialized in India and of the most sought after doctors in Cancer Specialist.
Does Dr. Kuraparthy Sambasivaiah offer Telemedicine Consultation through Medigence?
No, this doctor dose not offer telemedicine via MediGence
How many years of experience does Dr. Kuraparthy Sambasivaiah have?
Dr. Kuraparthy Sambasivaiah is one of the most sought after specialists in India and has over years of experience.
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