Dr. Fiona Lofts

Dr. Fiona Lofts

Cancer Specialist - Medical Oncologist

  Cancer Centre London, London, United Kingdom

BIOGRAPHY

Dr. Fiona Lofts is one of the finest Cancer Specialist in United Kingdom. He is an experienced Medical Oncologist in the United Kingdom. The Medical practitioner has been associated with various reputed hospitals in the United Kingdom. The physician is currently working as a Consultant Medical Oncologist, Cancer Centre London, United Kingdom. The doctor is a well-reputed and sought after medical expert and is

  • BSc
  • MBBS
  • PhD
  • FRCP

qualified. Dr. Fiona Lofts has been associated with many hospitals over the course of his illustrious and experienced career.

The hospitals include:

  • St George's Hospital

Dr. Fiona Lofts has more than of clinic experience. The Clinician specializes in and performs the following surgeries:

  • Chemotherapy
  • Oncology
CERTIFICATIONS (1)
  • Lofts qualified in 1983 from the Westminster Medical School, University of London. She obtained a BSc in physiology in 1980 and PhD in the molecular biology of the HER-2 onco-protein in 1993.
MEMBERSHIPS (5)
  • Member, Royal College of Physicians (1987)
  • Fellow, Royal College of Physicians(2001)
  • Member, British Association for Cancer Research
  • Member, European Association for Cancer Research
  • Member, European Society of Medical Oncology
Procedures
Chemotherapy

Chemotherapy is a category of standardized drug administration of various types for the treatment of cancer. With a curative intent, some combinations of drugs are administered to a patient to prolong their life and also to bring about a reduction in the symptoms shown by the patient. Chemotherapy treatment is considered to be one of the major categories of medical oncology. Many people around the world are prescribed to undergo chemotherapy treatment instead of undergoing a surgical procedure. But many are frightened with the side effects of this treatment as it is believed to reduce the quality of life of the patients.

What is chemotherapy?

Chemotherapy is a procedure where non-specific intracellular poisons are used, which are specifically related to preventing the process of mitosis or the natural cell division of the cancerous cells. This technique rather excludes those agents that are responsible for selective extracellular growth signal blockade (signal transduction blockers). If spoken about these agents used in chemotherapy, it has been found that most of them are cytotoxic in nature due to their property of interfering with natural mitosis. However, the cells of cancer can differ widely in terms of showing susceptibility to these administered agents.

Chemotherapy can be defined as a way of mass destruction of stress cells, which would eventually lead to the death of the cells when apoptosis is initiated. The commonly known side effects of chemotherapy can be traced back to the process of damaging normal non-cancerous cells, which are in the process of rapid division. They are sensitive to anti-mitotic drugs that are being administered to the patient and such cells may include the cells of the hair follicles, digestive tract lining, and bone marrow. But nowadays treatment options have undergone a lot of modification by which these side effects can be well countered.

Types of Chemotherapy Drugs

Various options of drugs are available to treat different types of cancer including the following:

Alkylating agents: These kinds of agents prove to be extremely beneficial during the cell’s resting phase. The various kinds of alkylating agents that are employed in chemotherapy treatment include the following:

  • Mustard gas derivatives: Cyclophosphamide, mechlorethamine, chlorambucil, ifosfamide, melphalan
  • Ethylenimines: Thiotepa and hexamethylmelamine
  • Alkylsulfonates: Busulfan
  • Metal salts: Oxaliplatin, cisplatin, and carboplatin
  • Nitrosoureas: Streptozocin, lomustine, carmustine

Nitrosoureas are unique from the rest for choices in chemotherapy treatment due to their ability to cross the blood-brain barrier and treating tumors of the brain.

Plant alkaloids: Plant alkaloids employed for chemotherapy treatment are derived from plants.  These include vinca alkaloids, taxanes, podophyllotoxins, and camptothecan analogs. The plant alkaloids are cell cycle specific agents, which enables them to attack the dividing cells in various stages of their division cycle.

Antimetabolites: This kind of chemotherapy treatment involves substances that are similar in composition to the normal substances present in the cell. When these substances get incorporated in the process of cellular metabolism, then the cell is no longer able to divide. They are also cell cycle specific and can be classified further according to the substance in the cell with which they interfere.

Topoisomerase inhibitors: When the topoisomerase enzymes in the body ( topoisomerase I and II) are inhibited as a result of chemotherapy drugs, then those drugs are referred to as topoisomerase inhibitors. During the chemotherapy, the topoisomerase enzymes are responsible for controlling structural manipulation of the DNA which is necessary for the purpose of replication.

Miscellaneous antineoplastics: Different types of drugs make each chemotherapy treatment process unique. Enzymes, retinoids, adrenocortical steroid inhibitor, ribonucleotide reductase inhibitor or antimicrotubule agents can be used as chemotherapy drugs.

Frequently Asked Questions
What area of specialization does Dr. Fiona Lofts have?
Dr. Fiona Lofts is specialized in United Kingdom and of the most sought after doctors in Cancer Specialist.
Does Dr. Fiona Lofts offer Telemedicine Consultation through Medigence?
No, this doctor dose not offer telemedicine via MediGence
How many years of experience does Dr. Fiona Lofts have?
Dr. Fiona Lofts is one of the most sought after specialists in United Kingdom and has over years of experience.
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