
Squamous cell carcinoma (SCC) or cutaneous squamous cell carcinoma (CSCC) is the second most frequent type of skin cancer, following basal cell carcinoma. It begins in squamous cells in your outer layer of skin, the epidermis. Squamous cell carcinomas typically develop on sun-exposed skin parts, such as your head, arms and legs. Cancer can also develop in the parts of your body where you have mucous membranes, that is, the inner lining of your organs and body cavities such as in your mouth, lungs and anus.
Depending on the location and extent of the cancer in your body, there are various forms of squamous cell carcinoma:
Squamous cell carcinoma (SCC) should be treated early to enhance cure rates, reduce complications, and prevent the cancer from spreading. Early detection allows for more effective therapy, often resulting in less invasive procedures and a better quality of life for the patient. Delaying treatment can cause more aggressive, costly, and less likely to heal cancer.
Depending on the location of the cancer, squamous cell carcinoma (SCC) symptoms may differ, but they generally include:
Skin Lesions: A flat, scaly, crusted lesion or a firm, red nodule often seen on sun-shaded areas like the hands, face, ears, or neck.
Bleeding or Ulceration: Bleeding, ulceration, or an unhealing scab is caused by the tumour.
Pain or Tenderness: The affected region becomes painful or tender upon palpation.
Itching or Burning: Itching or burning can be associated with the lesion.
Lumps or Swelling: Lumps can occur in the neck or nearby regions if SCC invades lymph nodes.
Causes
Squamous cell carcinoma is due to a mutation of the p53 gene. Ultraviolet (UV) light from the sun or indoor tanning beds is the most common cause of mutations of the p53 gene.
Risk Factors
Recent studies in Turkey show an increasing prevalence of squamous cell carcinoma (SCC), its frequency tending towards that of basal cell carcinoma. Modern treatments are cryotherapy, photodynamic therapy, radiotherapy, excisional surgery, Mohs surgery, and curettage, providing several choices for efficient management.
There are a few tips to prevent squamous cell carcinoma, including:
Chemotherapy: kills cancer cells by using potent medications. Chemotherapy can be used either alone or in conjunction with other therapies, such as radiation therapy and targeted therapy if squamous cell carcinoma spreads to the lymph nodes or other areas of the body.
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Targeted therapy: Drugs that target particular molecules in cancer cells are used in targeted therapy. Targeted therapies can kill cancer cells by preventing these molecules from functioning. Chemotherapy is typically combined with targeted therapy.
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Immunotherapy: It is a treatment that assists the body's immune system in destroying cancerous cells. The immune system targets bacteria and other cells that shouldn't be in the body to fight against illnesses. To survive, cancer cells hide themselves from the immune system. Immunotherapy aids the cells of the immune system in locating and eliminating cancer cells.
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Cryosurgery: The process of freezing cancer cells to kill them.
Photodynamic treatment (PDT): Using light-sensitive chemicals and blue light to eradicate skin cancer.
Curettage and electrodesiccation include using a spoon-like tool (curette) to scrape off the malignant lump and then using an electric needle to burn the region.
Excision is the process of removing the cancer from your skin and then stitching it back together.
Mohs surgery: Usually performed for face malignancies, this procedure involves removing cancerous skin layers.
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Turkey's advanced medical infrastructure, highly qualified medical personnel, and availability of the newest research and technologies make it an excellent destination for treating squamous cell carcinoma (SCC). For SCC, the top institutions in the US provide state-of-the-art care, including immunotherapy, targeted medicines, and novel surgical alternatives. International clinical trials are also conducted in Turkey, giving patients access to exciting new therapies.
Yes, squamous cell carcinoma (SCC) can spread to other body parts if left untreated in its initial stages. It can metastasise to distant sites such as the lymph nodes, lungs, liver, or bones or locally spread to adjacent tissues. Early diagnosis and treatment are essential for a good prognosis since SCC becomes increasingly more challenging to treat when it metastasises.
Following an assessment of these variables, the oncologist will classify the tumour into one of the following phases of squamous cell carcinoma:
Stage 0: Only the epidermis, or the outermost layer of the skin, has cancer.
Stage 1: The cancer has advanced profoundly into the skin, but it hasn't reached any healthy tissues or lymph nodes nearby.
Stage 2: Cancer has not migrated to neighbouring lymph nodes or healthy tissues, but it has deepened into the skin and exhibits one or more high-risk characteristics (such as metastases to nerves or lower skin layers).
Stage 3: Although the cancer has spread to lymph nodes, it has not yet reached any other organs outside the skin.
Stage 4: The disease has progressed to one or more distant organs, including the liver, lungs and part of the skin.
The location, stage, and overall health of the patient are among the factors that influence the survival rate of squamous cell carcinoma (SCC) in Turkey, as elsewhere. The survival rate for localised SCC is typically high, i.e., the cancer has not metastasised outside the original site. The key to better outcomes is early diagnosis and treatment.
Squamous cell carcinoma (SCC) can recur after treatment, mainly if it is advanced or not fully cured. Recurrence is more likely to happen if the patient has a history of skin cancer or if the tumour has spread to lymph nodes or surrounding tissues.
Regular follow-up and monitoring are necessary to detect recurrence symptoms early and initiate the appropriate treatment.
Squamous cell carcinoma (SCC) cannot be transmitted. It cannot be passed from person to person by touch, contact, or commingling surroundings. SCC is a type of skin cancer not caused by bacteria, viruses, or other infectious processes; it arises from injury caused by conditions such as smoking, UV radiation, or specific infection. Environmental exposure and personal habits are generally responsible for the risk factors of SCC.
Yes, you can get a second opinion on Squamous Cell Carcinoma treatment in Turkey through MediGence. With MediGence, you can connect with highly experienced professionals from top Turkish hospitals who can provide additional information regarding your diagnosis and treatment options. The platform facilitates easy access to professional help so you can make informed healthcare choices and receive the best care possible.
To find a certified cancer specialist, search MediGence’s website, which offers a list of top-class and internationally trained oncologists from Turkey's best hospitals. Through MediGence, you can search the profiles of specialists, check their credentials, reviews, and experience, and book online consultations. To get the best care for your condition, the website also assists you in finding the best hospitals and provides personalised assistance for your health requirements.