Dr. Puneet Gupta

Dr. Puneet Gupta

Cancer Specialist - Radiation Oncologist,Medical Oncologist

  Metro Hospital, Delhi / NCR, India

  24 Years of experience

BIOGRAPHY

Dr. Puneet Gupta is one of the finest Cancer Specialist in India. He is an experienced Radiation Oncologist in the India. The Medical practitioner has been associated with various reputed hospitals in the India. The physician is currently working as a Director -Radiation Oncology & Medical Oncology, Metro Hospital, India. The doctor is a well-reputed and sought after medical expert and is

  • MBBS - Himachal Pradesh University, 1988
  • MD - Utkal University, Orissa, India, 1992
  • DNB (Radiation Oncology) - National Board Of Examination, Mumbai TMH Center, 1994
  • MNAMS - National Board Of Examination
  • DM (Medical Oncology) - The Tamil Nadu Dr. M.G.R. Medical University, Chennai, 1996

qualified. Dr. Puneet Gupta has been associated with many hospitals over the course of his illustrious and experienced career.

The hospitals include:

  • Director Oncology - Apollo
  • Consultant - Max Hospital
  • Consultant - Dharamshila
  • Consultant - Batra Hospital
  • Consultant - Safdarganj Hospital
  • MD Anderson Cancer Centre, USA, Vienna University Hospital, Austria, Singapore General Hospital, etc.

Dr. Puneet Gupta has more than 24 Years of clinic experience. The Clinician specializes in and performs the following surgeries:

  • Chemotherapy
  • Intensity-modulated radiotherapy (IMRT)
  • Stereotactic Radio Therapy (SRT)
  • Oncology
MEMBERSHIPS (2)
  • Delhi Medical Council (DMC)
  • Medical Council of India (MCI)
Procedures
Chemotherapy

Chemotherapy is a category of standardized drug administration of various types for the treatment of cancer. With a curative intent, some combinations of drugs are administered to a patient to prolong their life and also to bring about a reduction in the symptoms shown by the patient. Chemotherapy treatment is considered to be one of the major categories of medical oncology. Many people around the world are prescribed to undergo chemotherapy treatment instead of undergoing a surgical procedure. But many are frightened with the side effects of this treatment as it is believed to reduce the quality of life of the patients.

What is chemotherapy?

Chemotherapy is a procedure where non-specific intracellular poisons are used, which are specifically related to preventing the process of mitosis or the natural cell division of the cancerous cells. This technique rather excludes those agents that are responsible for selective extracellular growth signal blockade (signal transduction blockers). If spoken about these agents used in chemotherapy, it has been found that most of them are cytotoxic in nature due to their property of interfering with natural mitosis. However, the cells of cancer can differ widely in terms of showing susceptibility to these administered agents.

Chemotherapy can be defined as a way of mass destruction of stress cells, which would eventually lead to the death of the cells when apoptosis is initiated. The commonly known side effects of chemotherapy can be traced back to the process of damaging normal non-cancerous cells, which are in the process of rapid division. They are sensitive to anti-mitotic drugs that are being administered to the patient and such cells may include the cells of the hair follicles, digestive tract lining, and bone marrow. But nowadays treatment options have undergone a lot of modification by which these side effects can be well countered.

Types of Chemotherapy Drugs

Various options of drugs are available to treat different types of cancer including the following:

Alkylating agents: These kinds of agents prove to be extremely beneficial during the cell’s resting phase. The various kinds of alkylating agents that are employed in chemotherapy treatment include the following:

  • Mustard gas derivatives: Cyclophosphamide, mechlorethamine, chlorambucil, ifosfamide, melphalan
  • Ethylenimines: Thiotepa and hexamethylmelamine
  • Alkylsulfonates: Busulfan
  • Metal salts: Oxaliplatin, cisplatin, and carboplatin
  • Nitrosoureas: Streptozocin, lomustine, carmustine

Nitrosoureas are unique from the rest for choices in chemotherapy treatment due to their ability to cross the blood-brain barrier and treating tumors of the brain.

Plant alkaloids: Plant alkaloids employed for chemotherapy treatment are derived from plants.  These include vinca alkaloids, taxanes, podophyllotoxins, and camptothecan analogs. The plant alkaloids are cell cycle specific agents, which enables them to attack the dividing cells in various stages of their division cycle.

Antimetabolites: This kind of chemotherapy treatment involves substances that are similar in composition to the normal substances present in the cell. When these substances get incorporated in the process of cellular metabolism, then the cell is no longer able to divide. They are also cell cycle specific and can be classified further according to the substance in the cell with which they interfere.

Topoisomerase inhibitors: When the topoisomerase enzymes in the body ( topoisomerase I and II) are inhibited as a result of chemotherapy drugs, then those drugs are referred to as topoisomerase inhibitors. During the chemotherapy, the topoisomerase enzymes are responsible for controlling structural manipulation of the DNA which is necessary for the purpose of replication.

Miscellaneous antineoplastics: Different types of drugs make each chemotherapy treatment process unique. Enzymes, retinoids, adrenocortical steroid inhibitor, ribonucleotide reductase inhibitor or antimicrotubule agents can be used as chemotherapy drugs.

Intensity-modulated radiotherapy (IMRT)

Intensity-modulated radiotherapy (IMRT) is a type of conformal radiotherapy, a technology that enables the radiation oncologist to precisely target the tissues with cancer cells. . In this type of radiation therapy for cancer, the radiation beams closely take up the shape of the area that is being targeted.

IMRT is delivered through the standard radiotherapy machine, which is also known as the linear accelerator (LINAC). This machine has a device called multileaf collimator, which possesses lead leaves that can move independently to form a shape that best fits the target area.

Because the radiation beams can take up the shape of the target area, high dosage of radiation can be delivered to kill the cancer cells while minimizing exposure to the non-cancerous cells and tissues. IMRT proves to be highly effective in the case of head and neck cancer among other types of cancer.IMRT for prostate cancer is now available across all major hospitals around the world.

The efficiency of IMRT has already been tested for multiple cancers, including breast cancer. Latest advancements improving the efficacy of radiotherapy, however, continue to take place in the field of healthcare. This radiation treatment for cancer is already being used as a standard treatment for some cancer types.

Stereotactic Radio Therapy (SRT)

Stereotactic radiotherapy (SRT) is a type of technique used to precisely target radiation beams at the tumour. This is one of the latest innovations in the field of radiation therapy. Since this treatment requires special equipment, machine, and expertise, this treatment is not widely available across all cancer treatment hospitals.

SRT involves treatment of a tumour with the help of a special machine known as a linear accelerator (LINAC). This machine is used to deliver external radiation therapy in the case of normal radiation therapy and intensity-modulated radiation therapy (IMRT).

SRT treatment involves of small daily doses of radiation, which are also known as fractions. The patient may be advised to undergo anywhere between 3 to 30 fractions in a day, depending on the extent of cancer and the size of the area that is being targeted. SRT is mostly used for the treatment of smaller lesions and tumours and is less than 3 cms in size.

Stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) are types of SRT. SRS is also known as Gamma Knife surgery. It involves exposing the tumour to a very high dose of radiation in one to five fractions. Gamma Knife surgery is usually used for the treatment of a tumour in the central nervous system (CNS).

On the other hand, SBRT is a special procedure used for the treatment of tumours located outside the central nervous system. In this approach, radiation is delivered through different directions or positions of the body. It can be used for the treatment of small tumours in the lungs, pelvis, prostate, pancreas and other organs as well.

SRT is mostly used for the treatment of the following conditions:

  • Secondary brain tumours
  • Small lesion or brain tumour that has a well-defined edge
  • Glioma that may have returned after months or years of treatment

Gamma Knife surgery is different from CyberKnife radiation. The latter is used for the treatment of cancerous and non-cancerous tumours as well as other medical conditions. CyberKnife treatment is actually a frameless robotic radiosurgery system that delivers a high dose of radiation to the targeted location.

Frequently Asked Questions
What area of specialization does Dr. Puneet Gupta have?
Dr. Puneet Gupta is specialized in India and of the most sought after doctors in Cancer Specialist.
Does Dr. Puneet Gupta offer Telemedicine Consultation through Medigence?
No, this doctor dose not offer telemedicine via MediGence
How many years of experience does Dr. Puneet Gupta have?
Dr. Puneet Gupta is one of the most sought after specialists in India and has over 24 Years years of experience.
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