Dr. Prashant Mehta

Dr. Prashant Mehta

Cancer Specialist - Medical Oncologist,Surgical Oncologist,Hematologist

  Asian Institute Of Medical Sciences, Delhi / NCR, India

  12 Years of experience

BIOGRAPHY

Dr. Prashant Mehta is one of the finest Cancer Specialist in India. He is an experienced Medical Oncologist in the India. The Medical practitioner has been associated with various reputed hospitals in the India. The physician is currently working as a Consultant - Medical Oncology Hematology and Unit Head- BMT, Asian Institute Of Medical Sciences, India. The doctor is a well-reputed and sought after medical expert and is

  • MBBS – Maulana Azad Medical College , New Delhi
  • MD (Medicine)
  • DM, Medical Oncology (AIIMS, New Delhi)
  • European Society for Medical Oncology certification for excellent knowledge in the field of Medical Oncology

qualified. Dr. Prashant Mehta has been associated with many hospitals over the course of his illustrious and experienced career.

The hospitals include:

  • Consultant in Department of Medical Oncology/Hematology/BMT from January 2015 to June 2016 at Artemis Health Institute, Gurgaon
  • DM (Medical Oncology) in Department of Medical Oncology and Bone Marrow Transplant from Jan 2012 to Dec 2014 at All India Institute of Medical Sciences, New Delhi
  • Senior Resident in Department of Medical Oncology and Bone Marrow Transplant from Aug 2010 to Dec 2012 at All India Institute of Medical Sciences, New Delhi

Dr. Prashant Mehta has more than 12 Years of clinic experience. The Clinician specializes in and performs the following surgeries:

  • Bone Marrow Transplant
  • Brain Cancer Treatment
  • Breast Cancer Treatment
  • Chemotherapy
  • Lung Cancer Treatment
  • Mastectomy
  • Oral cancer Treatment
  • Oncology
  • Transplants
MEMBERSHIPS (5)
  • European Society of Medical Oncology (ESMO)
  • American Society of Clinical Oncology (ASCO)
  • Society of Medical Oncology of India (SOMOI)
  • Indian Cooperative oncology Network (ICON)
  • Core committee member of Molecular Oncology working group of ICON
Procedures
Bone Marrow Transplant

Stem cell transplant is one modern technology that is undergoing rapid improvements. It is said these days that instead of investing in various life insurance policies that are making the rounds in the market, to secure the future and precious life of your child go for stem cell technologies. This can later cure him or her from any life threatening terminal disease like cancer. Stem cell transplant has been used in recent times as a cure for cancer, but the technique is different from the stem cell bank that is maintained these days for new born.

 

Who needs a stem cell transplant?

The bone marrow which is part of the bones is responsible for making blood cells. It is soft and spongy tissue lodged inside the bone having hematopoietic stem cells. These cells either turn into bone marrow cells or can turn into any other kinds of cells or the blood cells. But there are certain forms of cancers that can keep these cells from developing normally.

A patient is recommended to get a blood as well as bone marrow stem cell transplant if they are in a condition which prevents the body from producing new healthy blood cells. Some of the conditions and diseases that prevent the bone marrow from doing so are given below:

  • Cancers like Myeloma, breast cancer, leukemia, Lymphoma may require stem cell transplant
  • Blood diseases which may require are sickle cell anemia, aplastic anemia and thalassemia
  • There are immune deficiency diseases like the congenital neutropenia, severe combined immunodeficiency syndrome, chronic granulomatous disease may demand a stem cell transplant.

The oncologist or hematologist shall decide for a stem cell transplant for a patient depending upon overall age and health, severity of the diseases and other treatment possibilities.

 

What is a stem cell transplant?

So the stem cell transplant is a kind of treatment to treat blood disorders or any types of cancer. Even blood diseases are also treated with transplants. Previously patients had to undergo a bone marrow transplant due to the fact that stem cells are collected from the bone marrow. But today stem cells get collected from the blood. And for this particular reason they are now called stem cell transplants. Nowadays stem cell therapies are used to combat hair loss and many other aesthetic related issues.

Some of the different types of stem cell treatments available are discussed below

Autologous transplant: These kinds of transplants are known as auto transplant. This kind of transplant has the scope  of very high dose chemotherapy paired with autologous stem cell rescue. In this process usually the doctors treat the cancel and then make use of the stem cells from the patient itself. From the blood, stem cells are collected and the health care team then freezes it. These cells are usually placed back in the blood after thawing them in the frozen state post the chemotherapy. The cells take almost 24 hours to reach the bone marrow and start multiplying to give rise to healthy blood cells.

Allogenic transplantation: This is better known as an allo transplant medically. In this case stem cells are obtained from another individual. But this individual needs to be someone with whom the bone marrow of the patient matches. Due to presence of proteins in white blood cells called the human leukocyte antigens (HLA) it is important that bone marrow matching takes place. The most compatible stem cell donor will have the HLA matching with that of the patient.

But the process of matching can also give rise to a very severe condition named graft versus host disease or GVHD but then it is not very likely. In this kind of a disease the healthy cells obtained from transplantation will start attacking the cells of the patients. In such cases siblings are considered to be the best match. And if they are not available then some other close family member can also work. Once the donor is fixed then the patient starts receiving chemotherapy session with or without radiotherapy. The other person’s stem is then placed in a vein via a tube. These cells unlike the previous ones are not frozen so they can be given immediately after the completion of chemotherapy.

There can be two types of Allo transplantation depending upon the age, condition and the disease that is being addressed:

The first kind is ablative where high dose of chemotherapy is used and in the second kind milder doses of chemotherapy is employed.

When the assigned health care team is unable to find a matched adult donor then are other options that must be considered like the Umbilical cord blood transplant and these days cancer centers all around the globe make use of cord blood.

Parent child transplant and haplotype mismatched transplant: In these kinds of transplants which are commonly employed the match found is 50% instead of 100% and the donor can be a parent, child or brother and sister.

Brain Cancer Treatment

 

Brain cancer can interfere with normal brain functions such as speech, movement, thoughts, feelings, memory, vision, and hearing. It is a disease of the brain in which abnormal, cancerous cells grow in the brain tissues. Typically, brain cancer is a developed form of a brain tumour. Primary brain cancer or a brain tumour develops from cells within the brain.

However, all brain tumours are not brain cancer. But one thing to note is that even benign tumour can cause serious problems by increasing intracranial pressure or obstruct vascular structures or cerebrospinal fluid flow in the brain.

Different types of cells in the brain such as gliomas, meningiomas, pituitary adenomas, vestibular schwannomas, and primitive neuroectodermal (medulloblastomas) can become cancerous. Gliomas have several subtypes, which include astrocytomas, oligodendrogliomas, ependymomas, and choroid plexus papillomas.

Types of Brain Cancers

There are two types of brain cancer, including:

  • Primary brain cancers: Primary brain cancers result when cancer cells develop in the tissues of the brain itself. Primary brain cancer cells may travel short distances within the brain but generally would not travel outside of the brain itself.
  • Secondary brain cancers: Secondary brain cancer is called metastatic brain cancer. It occurs when cancer develops elsewhere in the body and spreads to the brain. Primary cancer tissues can spread via direct extension, or through the lymphatic system or through the bloodstream.

Metastatic cancer in the brain is more common than primary brain cancer. They are usually named after the tissue or organ where cancer first develops. Metastatic lung or breast cancer in the brain is the most commonly found brain cancers.

Brain Cancer Causes

The exact brain cancer cause is still unknown. However, its occurrence has been linked to several risk factors, including the following:

  • Exposure to radiation
  • HIV infection
  • Inherited abnormality
  • Smoking
  • Exposure to environmental toxins
  • Exposure to chemical toxins, especially those used in rubber industry and oil refinery

Brain Cancer Symptoms

Some types of brain cancers such as meningeal and pituitary gland may produce few or no symptoms. Some of the brain cancer symptoms typically experienced by patients include:

  • Difficulty walking, seizures, dizziness and vertigo
  • Extreme fatigue and muscle weakness
  • Severe headaches and blurry vision
  • Sleepiness, nausea, and vomiting
  • Reduction in mental alertness, capacity or memory
  • Difficulty in speaking, impaired voice or inability to speak
  • Personality changes and hallucination
  • Weakness on one side of the body and coordination problems
  • Reduced touch sensation
Breast Cancer Treatment

The recent advances made in breast cancer treatment have revolutionized the way how women from this rare disorder are diagnosed and suggested a personalized treatment plan. These advances have made it easier for the doctors to arrive at a treatment plan, which is most suitable for the patient as per their individual characteristics and needs.

Different breast cancer treatment options help destruct complex mixture of cancer cells, which are otherwise difficult to treat using conventional breast cancer treatment. The treatment is started by the doctors handling the case as soon as the breast cancer diagnosis is confirmed.

Before the article delves into the different breast cancer treatment options, lets first take a look at how breast cancer develops and what are its symptoms and diagnosis methods.

Breast cancer: What do the statistics say?

Breast cancer primarily affects females aged above 40. However, that does not mean that it does not affect women aged below 40. Breast cancer can also affect males, although rarely.

Breast cancer starts in the cells of either one or both the breasts. It accounts for more than 16 percent of female cancer and contributes to 18.2 percent of all deaths that take place around the world because of cancer.

In the US alone, breast cancer affects more than 232,000 females and 2,200 males each year. It leads to death of more than 39,000 breast cancer patients in a year.

Breast Cancer Symptoms

The symptoms of breast cancer can be easily identified at home through breast self-examination. You should consult your physician on how to conduct this exam at home.

The most common breast cancer symptoms include:

  • Change in the size or shape of the breast
  • Lump in the breast
  • Swelling in armpit
  • Change in colour and shape of the nipples
  • Rash, redness or pitting on the breast skink
  • Pain in the breast or armpits
  • Abnormal discharge from the nipples

In case of more aggressive breast cancer called inflammatory breast cancer, severe redness and itching may be present.

The patients are advised to contact their physician as soon as they notice any of the symptoms of breast cancer. The physician is the best person to diagnose whether it is normal or inflammatory best cancer, and accordingly, suggest treatment for breast cancer.

Breast Cancer Causes

The exact reason that causes breast cancer is unclear, despite the fact that every eighth woman suffers from it. However, there are several factors that have been associated with the development of breast cancer. Some of the breast cancer risk factors include:

  • Prolonged use of birth control pills
  • Obesity
  • Use of hormone replacement therapy
  • High breast density
  • Alcohol addiction
  • No history of pregnancy
  • Pregnancy after 35
  • Exposure to radiation

The risk of breast cancer naturally increases as women age. The risk is also higher in women who have a family history of breast or ovarian cancer, possess BRCA1 and BRCA2 genes or who have had their periods before the age of 12.

Chemotherapy

Chemotherapy is a category of standardized drug administration of various types for the treatment of cancer. With a curative intent, some combinations of drugs are administered to a patient to prolong their life and also to bring about a reduction in the symptoms shown by the patient. Chemotherapy treatment is considered to be one of the major categories of medical oncology. Many people around the world are prescribed to undergo chemotherapy treatment instead of undergoing a surgical procedure. But many are frightened with the side effects of this treatment as it is believed to reduce the quality of life of the patients.

What is chemotherapy?

Chemotherapy is a procedure where non-specific intracellular poisons are used, which are specifically related to preventing the process of mitosis or the natural cell division of the cancerous cells. This technique rather excludes those agents that are responsible for selective extracellular growth signal blockade (signal transduction blockers). If spoken about these agents used in chemotherapy, it has been found that most of them are cytotoxic in nature due to their property of interfering with natural mitosis. However, the cells of cancer can differ widely in terms of showing susceptibility to these administered agents.

Chemotherapy can be defined as a way of mass destruction of stress cells, which would eventually lead to the death of the cells when apoptosis is initiated. The commonly known side effects of chemotherapy can be traced back to the process of damaging normal non-cancerous cells, which are in the process of rapid division. They are sensitive to anti-mitotic drugs that are being administered to the patient and such cells may include the cells of the hair follicles, digestive tract lining, and bone marrow. But nowadays treatment options have undergone a lot of modification by which these side effects can be well countered.

Types of Chemotherapy Drugs

Various options of drugs are available to treat different types of cancer including the following:

Alkylating agents: These kinds of agents prove to be extremely beneficial during the cell’s resting phase. The various kinds of alkylating agents that are employed in chemotherapy treatment include the following:

  • Mustard gas derivatives: Cyclophosphamide, mechlorethamine, chlorambucil, ifosfamide, melphalan
  • Ethylenimines: Thiotepa and hexamethylmelamine
  • Alkylsulfonates: Busulfan
  • Metal salts: Oxaliplatin, cisplatin, and carboplatin
  • Nitrosoureas: Streptozocin, lomustine, carmustine

Nitrosoureas are unique from the rest for choices in chemotherapy treatment due to their ability to cross the blood-brain barrier and treating tumors of the brain.

Plant alkaloids: Plant alkaloids employed for chemotherapy treatment are derived from plants.  These include vinca alkaloids, taxanes, podophyllotoxins, and camptothecan analogs. The plant alkaloids are cell cycle specific agents, which enables them to attack the dividing cells in various stages of their division cycle.

Antimetabolites: This kind of chemotherapy treatment involves substances that are similar in composition to the normal substances present in the cell. When these substances get incorporated in the process of cellular metabolism, then the cell is no longer able to divide. They are also cell cycle specific and can be classified further according to the substance in the cell with which they interfere.

Topoisomerase inhibitors: When the topoisomerase enzymes in the body ( topoisomerase I and II) are inhibited as a result of chemotherapy drugs, then those drugs are referred to as topoisomerase inhibitors. During the chemotherapy, the topoisomerase enzymes are responsible for controlling structural manipulation of the DNA which is necessary for the purpose of replication.

Miscellaneous antineoplastics: Different types of drugs make each chemotherapy treatment process unique. Enzymes, retinoids, adrenocortical steroid inhibitor, ribonucleotide reductase inhibitor or antimicrotubule agents can be used as chemotherapy drugs.

Lung Cancer Treatment

Lung cancer is an uncontrolled growth of cells that start off in the lungs. Usually, lung cancer starts in the cells that line the air passages. Instead of developing into healthy lung tissue, the cells divide rapidly and form tumours.

Lung cancer can grow and spread beyond the lung to reach other parts of the body through metastasis. Lung cancers can begin in any part of the lung, but 90 percent of lung cancers begin in the epithelial cells, which are the cells lining the larger and smaller airways also known as bronchi and bronchioles.

This is the reason why lung cancers are sometimes called bronchogenic cancers or bronchogenic carcinomas. Lung cancer is the most common cancer in the world, among both men and women. It is the leading cause of cancer deaths worldwide.

Lung Cancer: Causes and Risk Factors

Long-term smoking is the main cause of lung cancer. After smoking, genetic factors and exposure to radon gas, asbestos, second-hand smoke or other forms of air pollution can also increase the risk of lung cancer.

Types of Lung Cancer

There are two major types of lung cancers, based on the appearance of lung cancer cells under the microscope:

  • Non-small cell lung cancer (NSCLC): It is an umbrella term for several types of lung cancers that behave in a similar way, such as squamous cell carcinoma, adenocarcinoma, and large cell carcinoma.
  • Small cell lung cancer (SCLC): This type of lung cancer occurs mostly in heavy smokers and it is less common than non-small cell lung cancer. 

Lung Cancer Stages

It is necessary to determine the stage of lung cancer by finding out how far cancer has spread, before initiating treatment of lung cancer.
The following are the four lung cancer stages of NSCLC:

  • Stage 1 lung cancer: Cancer is restricted to the lung
  • Stage 2 lung cancer: Cancer has spread to the nearby lymph nodes
  • Stage 3 lung cancer: (3a) Cancer is in the lung and the lymph nodes located on the same side  (3b) Cancer is in the lung and has spread to lymph nodes on the opposite side
  • Stage 4 lung cancer: Cancer has spread to both the lungs and other organs and surrounding tissues

The following are the two lung cancer stages of SCLC:

  • Limited stage: Cancer is present in just one lung and lymph nodes on the same side of cancer.
  • Extensive stage: Cancer has spread throughout the lung or both the lungs, to the lymph nodes on the opposite side, to the bone marrow, and to the distant organs.

After the determination of stage, treatment of lung cancer starts with choosing the best suitable option for the patient. However, there is usually no single treatment for lung cancer. So the patient often receives a combination of therapies and palliative care. 

Lung Cancer Symptoms

Lung cancer symptoms may vary, depending upon where and how widespread the tumour is. A person with lung cancer may have following lung cancer symptoms:

  • A persistent or chronic coughing
  • Pain in chest, shoulder or back
  • Difficulty in breathing and shortness of breath
  • Hoarseness or change of voice
  • Chronic bronchitis, pneumonia or respiratory infections
  • Blood in the sputum and cough


Stage 3 lung cancer symptoms include the following:

  • Wheezing
  • General pain in the chest or when breathing
  • Persistent cough with or without blood
  • Altered voice
  • Loss of appetite
  • Unplanned weight loss
  • Fever, headache, weakness, and bone pain
  • Difficulty swallowing
Mastectomy

Mastectomy refers to the partial or complete surgical removal of one or both the breasts. This surgery is most often indicated for breast cancer.

A lump in the breast or armpits is one of the earliest signs of breast cancer. It can cause a change in the shape, size, or color of the breast or nipple. Nipple tenderness, inward folding of the nipple, discharge from the nipple, and orange peel appearance of the skin of the breast are the other signs of breast cancer. Patients who observe any of the above-mentioned signs must see their physician immediately.

Who are advised to undergo breast cancer mastectomy?

Your physician may recommend you to undergo a partial or full mastectomy in the following conditions:

  • If you have a massive malignant tumor in the breast or invasive ductal carcinoma
  • If you have had a recurrent breast cancer after initial lumpectomy
  • If you are pregnant and have been diagnosed with breast cancer and radiation therapy is contraindicated
  • If you have a medical history of scleroderma and have been diagnosed with breast cancer
  • If you are diagnosed with breast cancer and have a lump in the armpits

Additionally, if you have a family history of breast cancer or deleterious mutation of BRCA 1 and BRCA 2 genes, you are advised preventive mastectomy.

Oral cancer Treatment

Oral cancer, commonly referred to as mouth cancer or throat cancer, is an uncontrollable growth of cells in the oral cavity. It refers to cancer that develops in any of the parts that make up the mouth. It can include cancer of the lips, tongue, cheeks, the floor of the mouth, pharynx (throat), hard and soft palate and either of the sinuses. Mouth and oropharyngeal cancer can be life-threatening, but it could be prevented if the cancer is diagnosed early enough.

What Causes Oral Cancer?

Oral cancer is a result of a mutation in the DNA of the cells in the mouth. There are certain identified risk factors for mouth cancer that predisposes a person to oral cancer.

Some of the oral cancer risk factors include:

  • Smoking: Smoking tobacco (cigarettes, cigars, and pipes) contains nitrosamines and other chemicals that are known to cause cancer. People who are exposed to passive smoking also experience a small increase in their risk of oral cancer.  
  • Chewing tobacco: Use of any type of tobacco is one of the main reasons behind oral cancer. Chewing tobacco is not a safe alternative to cigarettes. It is a popular habit in parts of Asia and in some immigrant groups in Europe, North America, and Australia. The harmful substances in tobacco and betel can cause oral cancer.
  • Alcohol consumption: Drinking excessive alcohol increases the risk of oral cancer. Using tobacco and alcohol both pose a much greater risk than using either of the substance alone.
  • Poor diet: Lack of vitamins and minerals, such as iron or folic acid in the diet, can lead to a breakdown in the oral mucosa and this can make people more prone to oral cancer. People should eat plenty of proteins, vitamins, and minerals to decrease the risk of oral cancer. Fresh fruits and vegetables contain a lot of antioxidants, vitamins and other substances that help prevent damage to body cells.
  • A family history of disease: There is a slightly higher risk of getting oral cancer in people who have a close relative who once had oral cancer.
  • Human Papilloma Virus (HPV): HPV can contribute to some types of cancers, but it does not mean that people get these cancers like an infection. HPV can be passed on to another individual during a sexual contact, but for a majority of people, the virus is harmless and does not cause any trouble. Only a very small percentage of people with HPV end up developing oral cancer.

Oral Cancer Symptoms

There are some typical signs of mouth cancer that a majority of patients experience. Make sure to visit your doctor or dentist in case you experience any of the following signs of mouth cancer:

  • Pain and discomfort in the mouth: Ongoing pain or discomfort from a long time in the mouth is the one of the most symptoms.
  • Ulcers and sore: Bleeding ulcer or sore, which is not healing for more than two weeks can be a symptom of oral cancer.
  • Unexplained bleeding: Unexplained bleeding in the mouth can be an alarming indication of oral cancer.
  • Numbness and lost sensation: Numbness, loss of feeling or tenderness in any area of the mouth, or neck can be a symptom.
  • White or red patches: Any abnormal looking patches in the mouth or throat could be a sign of cancer or precancerous changes. Although, a fungal infection called thrush can also be the reason for white or red patches.
  • Difficulty in swallowing: You may feel difficulty in chewing and swallowing and feel like your food is sticking in your throat. Feeling difficulty in speaking or moving the jaw and tongue can be one of the most important throat cancer symptoms.
  • Weight loss: Dramatic weight loss without any reason can also be a symptom.
Frequently Asked Questions
What area of specialization does Dr. Prashant Mehta have?
Dr. Prashant Mehta is specialized in India and of the most sought after doctors in Cancer Specialist.
Does Dr. Prashant Mehta offer Telemedicine Consultation through Medigence?
No, this doctor dose not offer telemedicine via MediGence
How many years of experience does Dr. Prashant Mehta have?
Dr. Prashant Mehta is one of the most sought after specialists in India and has over 12 Years years of experience.
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