Oligodendroglioma Treatment in India
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What is Oligodendroglioma?
As a tumor of the central nervous system, oligodendroglioma affects the brain (and in rare cases, the spinal cord). It begins in a particular kind of glial cell, which supports the nervous system. Even when oligodendroglioma is malignant, experts believe it is a fairly curable tumor with generally good survival rates.
What can I expect if my parents have Oligodendroglioma?
Depending on where the tumor is located in the brain, your parents may have symptoms like seizures, headaches, difficulty speaking, weakness or numbness on one side of the body, balance problems, and difficulty thinking and remembering things.
What are the Common Symptoms of Oligodendroglioma?
Oligodendrogliomas, like many brain tumors, frequently don't show any symptoms until they start to disrupt the surrounding brain tissue. Seizures or headaches are the most typical symptoms. Approximately 80% of patients with oligodendroglioma will experience a seizure as a result of the cancer. This is due to the fact that oligodendrogliomas frequently impact the cerebral cortex, the wrinkled outer layer of the brain. The brain regions that govern many of your daily skills, including vision, language, muscular control, and more, are located in the cortex. Other symptoms include:
- Weakening or paralysis of the muscles, particularly on one side of the face or body
- Loss of hearing
- Aphasia is the inability to communicate or understand what others are saying, clouded vision, double vision, or vision loss
- Issues with memory
- Difficulty focusing or thinking
Causes, Risk Factors and Complications of Oligodendroglioma.
CausesAll oligodendrogliomas are caused by two distinct DNA alterations, by definition:
1p/19q co-deletion: Cells employ their chromosomes, which are compacted DNA "data," as a guide. Errors can occasionally occur during chromosomal copying during cell division. The long (q) arm of chromosome 19 and the short (p) arm of chromosome 1 are always deleted in oligodendrogliomas. This is frequently referred to by experts as a "1p/19q co-deletion."
Mutations in IDH1 or IDH2: Sections of your DNA that contain particular instructions are called genes. One of them instructs your body on how to produce isocitrate dehydrogenase (IDH), an enzyme that aids in specific metabolic processes. Oligodendrogliomas can result from any of the two IDH mutations, IDH1 or IDH2.
Risk FactorsThere are currently no known risk factors for oligodendroglioma. However, some research suggests that prior radiation therapy, such as that used to treat other cancers, may be a risk factor for the development of gliomas, which are related tumors. To determine whether something could be a cause or contributing factor, more investigation is required.
ComplicationsBecause oligodendrogliomas impact the brain, they may result in a variety of issues. The location of the oligodendroglioma, along with any other medical disorders one may have, will determine the complications patient may have.
Among the issues to be mindful of are:
Malignant transformation: Low-grade, non-cancerous oligodendrogliomas can occasionally "transform." This indicates that the tumor cells develop into malignant ones over time.
Strokes or other issues related to the circulatory system: As an oligodendroglioma grows inside your skull or brain, it will displace the surrounding brain tissue as it takes up more and more room. Strokes or stroke-like events may result from that.
Changes in skull structure: Oligodendrogliomas frequently become calcified, or hardened, as a result of calcium buildup. The skull bone may begin to be impacted when that occurs on the outside of your brain. An oligodendroglioma that grows slowly may also induce changes or shifts in the surrounding bone tissue.
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Latest Research and Technologies in the Treatment of Oligodendroglioma in India.
The use of genomic research to our present standard of care for brain tumors, including sophisticated next-generation sequencing (NGS) to decode their genomic properties, was made possible by technological advancements throughout the past ten years. As a result, patients might get comprehensive NGS panel findings that list a number of mutations linked to tumors. Despite a lot of progress, we still don't fully grasp the therapeutic implications of those mutations or how a particular genetic profile influences the prognosis for a given patient. This is particularly true with oligodendrogliomas, where a 10- to 20-year follow-up may be necessary to determine the effect on prognosis.
Oligodendroglioma Prevention Tips
The causes and risk factors for oligodendrogliomas are unknown to experts. As a result, there is no method to avoid it or lower your chance of developing it.
Treatment options for Oligodendroglioma
Chemotherapy : Oligodendroglioma can be effectively treated with some chemotherapeutic medications. The following are the most likely chemotherapy treatments.
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Radiation treatment: Oligodendroglioma is frequently treated with radiation therapy. With this method, tumor cells are subjected to enough energy to be destroyed. The radiation is aimed as accurately as it can be.
A medical professional will use a variety of techniques to diagnose oligodendroglioma, such as:
- A neurological and physical examination
- Imaging for diagnosis
- A pathology test and a brain biopsy
Because diagnostic imaging allows medical professionals to "see" within your skull, it is particularly crucial when oligodendrogliomas are present. The following scans are the most likely to be helpful:
Computed tomography (CT) scans: Following a seizure or other focused symptoms, these are frequently the initial imaging tests performed. Because they contain calcium, your bones appear bright on CT and X-ray images. Because oligodendrogliomas frequently include calcium, they frequently exhibit a brilliant appearance.
The many structures inside your head can be readily seen on magnetic resonance imaging (MRI) images. They can assist in pinpointing the exact location and size of an oligodendroglioma.
However, an oligodendroglioma cannot be diagnosed using imaging scans alone. They merely offer proof that you have a brain tumor that may be an oligodendroglioma. Providers use that evidence to decide if you require pathology testing and a brain biopsy.
Treatment for oligodendroglioma can damage brain regions involved in motor control and cognitive function. You may require assistance to regain your mobility, speech, vision, and cognitive function following therapy.
- Physical therapy is one treatment that may be helpful in helping patients regain lost muscle strength or motor skills
- Following a brain tumor or other sickness, occupational therapy can assist patients in returning to their regular activities, including their jobs
- Speech therapy, which might be beneficial if you have trouble communicating.
School-age children can benefit from tutoring to help them deal with memory and cognitive changes following a brain tumor.
If your oligodendroglioma is causing symptoms, you might need medicine to make you more comfortable. Which medications you need depends on your situation. Options might include:
- Medicine to control seizures
- Steroid medicines to reduce brain swelling
- Medicine to improve alertness if you have severe fatigue.
Medicine to help with thinking and memory problems.
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Hospitals for Oligodendroglioma in India
Batra Hospital
Delhi, India
- More than 35 years of trusted healthcare service
- Multi-specialty tertiary care with over 30 departments
- Comprehensive preventive, diagnostic, and therapeutic care under one roof
- International patient coordination team for seamless overseas care
Marengo Asia Hospitals, Gurugram
Gurgaon, India
- Marengo Asia Hospitals, Gurugram, is a 250-bed multi-speciality tertiary care hospital, formerly known as W Pratiksha Hospital.
- A major medical centre for Delhi NCR and North India, it is situated on Golf Course Extension Road, Sector 56, Gurugram.
- The hospital's NABH and NABL accreditation ensures compliance with international standards for patient care, safety, and quality.
- Provides extensive medical care in more than 21 specialities, including as women's health, neurology, orthopaedics, cardiology, and cancer.
- Advanced robotic-assisted spine surgery tools and neuro-monitoring technology are available at the Marengo Asia International Institute of Neuro & Spine (MAIINS), a Centre of Excellence in Neurosciences.
- Equipped with cutting-edge equipment, such as automated labs, sophisticated imaging, and contemporary operating rooms.
- Features specialised ICUs, NICUs, and modular OTs built for complex and minimally invasive procedures.
Jaslok Hospital & Research Center
Mumbai, India
- Jaslok Hospital & Research Centre, Mumbai, is a 350-bed super-speciality tertiary care hospital, established in 1973 and among India’s most respected private trust hospitals.
- Located on Peddar Road in South Mumbai, overlooking the Arabian Sea, it serves as a major referral centre for Mumbai, Maharashtra, and patients from across India and abroad.
- The hospital offers comprehensive care across 50+ specialities and nearly 20 multidisciplinary speciality clinics, addressing complex and advanced medical conditions.
- Supported by 300+ senior consultants and 200 resident doctors, ensuring high standards of expertise and round-the-clock patient care.
- Equipped with 75 ICU beds, advanced critical care units, modular operation theatres, and state-of-the-art diagnostic and imaging facilities.
- Recognised as a leading centre of excellence in Critical Care, Cardiac Sciences, Neurosciences, Oncosciences, Renal Sciences, Gastroenterology, and Assisted Reproduction.
- A prominent research and academic institution, conducting clinical trials and recognised by the National Board of Examinations (NBE) in 22 specialities.
- Strong emphasis on quality, patient safety, and evidence-based care, with continuous monitoring of clinical and operational outcomes to meet international healthcare standards.
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Why Choose India for Olfactory Neuroblastoma Treatment?
Here are some of the reasons for choosing India:
Due to advancements in medical facilities, such as minimally invasive surgical techniques.
- World-class experts include highly experienced doctors, JCI, and NABH-accredited healthcare institutions.
- Compared to other countries, treatment in Indian hospitals is cost-effective.
- Indian hospitals provide international patient services, including a multilingual support system.
Improved treatment methods and biological therapies.
Frequently Asked Questions
Although they are not strictly "curable," oligodendrogliomas are treatable malignancies. The most common treatment for oligodendroglioma is to remove the entire tumor, or as much of it as feasible. Your care team will next assess if chemotherapy, radiation therapy, or a combination of these treatments are required to eliminate any cancer cells that may still be present.
With skilled neurosurgeons, oncologists and cutting-edge medical technology, India has demonstrated significant success rates in treating oligodendrogliomas. The nation's healthcare institutions offer top-notch treatment alternatives, guaranteeing successful outcomes for many patients.
Yes, many Indian hospitals offer the following for oligodendrogliomas treatment:
- Advanced diagnostic tools like MRI, CT scan, electromyography, and PET scan for accurate neurofibroma diagnosis.
- Skilled neurologist, oncologist and surgeons for oligodendrogliomas.
- Advanced radiation therapy and chemotherapy procedures.
- Comprehensive post-surgery care and rehabilitation for long-term health benefit.
How can I choose India's top doctor and the best oligodendroglioma treatment hospital?
Always consider the following factors when selecting Indian hospitals:
- Hospitals that are accredited (authorised by JCI and NABH).
- Patient reviews and success rates.
- Hospitals that provide seamless care to patients from abroad.
In general, oligodendroglioma treatment has much improved in India. For oligodendroglioma, the relative five-year survival rate is 79.5%. The prognosis is influenced by numerous circumstances, though. These include the patient's age and health at diagnosis, the tumor grade and molecular type, and the response to treatment. The five-year survival rate is higher for younger adults. High-grade oligodendroglioma has a five-year survival rate of 45% to 76%.
Oligodendroglioma is a severe worry because it is a sort of brain tumor. However, compared to other forms of gliomas, it is less harmful and more curable. The majority of people are unaware that they have oligodendroglioma until they experience symptoms, particularly headaches or seizures. Emergency medical attention is always required for a first seizure. When a headache occurs frequently, during specific activities, or in a way that interferes with your parent’s life, you should seek medical assistance.
An imaging examination that initially finds an oligodendroglioma is typically the result of symptoms. Once identified, a medical professional will suggest tests to identify the condition and decide on a course of treatment. Oligodendroglioma must be treated because even benign, low-grade tumors have the potential to develop into malignancy. One important strategy to stop oligodendroglioma from getting worse or spreading to other areas of your body is to stop its spread.
The survival of patients with oligodendroglial tumors is considerably increased by oncological treatment. It is yet unknown, though, how harmful it might be to long-term survivors' cognitive function. After more than five years of treatment completion, our study revealed that patients with WHO grades II and III oligodendroglial tumors exhibit cognitive impairment, which can be severe in up to 38% of cases. This is accompanied by structural GM and WM damage, underscoring the need for future strategies in patients with long expected survival.
Your healthcare practitioner will assist you in selecting the best course of treatment for your parents if they have oligodendroglioma. Additionally, they will suggest a course of therapy and frequent follow-up appointments.
It's crucial to take them to follow-up appointments and therapies. It's also critical to ensure they receive treatment on a regular basis and according to prescriptions.
Many of the treatments for oligodendroglioma have side effects. They can learn about the potential side effects that are most likely to occur and what you can do to mitigate them from your healthcare professional.