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What is Hepatocellular Carcinoma (HCC)?

Hepatocellular carcinoma is the most common type of liver cancer. It is an aggressive (fast-growing) cancer that most commonly affects persons with severe liver disease, such as cirrhosis. People with HCC are increasingly being diagnosed with metabolic dysfunction-associated steatotic liver disease (MASLD), which can develop to cirrhosis.

What is the Importance of Timely Treatment?

  • Early treatment of Hepatocellular Carcinoma (HCC) is essential for improving patient outcomes and survival rates.
  • Early discovery enables more effective treatment choices, such as surgical resection, liver transplantation, or local therapy (e.g., ablation or embolisation), which may cure the cancer or considerably postpone its progression.
  • Delaying treatment can cause tumour growth, spread (metastasis), and poor liver function, making cancer more difficult to cure and decreasing the likelihood of a favourable outcome.
  • Early intervention also enhances quality of life by enabling more effective symptom management.

What are the Common Symptoms of Hepatocellular Carcinoma (HCC)?

Tumours may not present symptoms in their early stages. However, as HCC proceeds, you may notice the following:

  • Fullness or a knot under your right ribs (symptoms of an enlarged liver).
  • Fullness under your ribs on the left side (symptoms of an expanded spleen).
  • Yellowing of the eyes and skin (an indication of jaundice).
  • A distended stomach, as if it is overflowing with fluid.
  • Appetite loss or feeling full after eating a little meal.
  • Unexplained weight loss.
  • Nausea and vomiting.
  • Itching.

Causes and Risk Factors of Hepatocellular Carcinoma (HCC)

Causes

  • Hepatocellular carcinoma occurs when liver cells' DNA undergoes modifications (mutations).
  • A cell's DNA contains the instructions for every chemical process in your body. DNA mutations alter these instructions.
  • As a result, cells may grow out of control, eventually becoming a tumour—a mass of malignant cells.

Risk Factors

The following conditions enhance your risk of developing HCC:

  • Hepatitis B infection: Hepatitis B infection can cause HCC even in the absence of liver cirrhosis or before it develops.
  • Hepatitis C Infection: A viral infection that spreads through blood.
  • Metabolic dysfunction-associated steatotic liver disease (MASLD): It is a disorder that causes excessive fat to accumulate in the liver.
  • Alcohol use disorder: The liver has a tough time processing alcohol. Drinking too much of it can cause cirrhosis and liver cancer.

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Latest Research and Technologies in the Treatment of Hepatocellular Carcinoma (HCC) in Turkey

  • Turkey has achieved significant advances in treating hepatocellular carcinoma (HCC).​
  • Transarterial chemoembolisation (TACE) and Yttrium-90 radioembolisation have improved equivalent survival, improving patient outcomes. ​
  • Liver transplantation, which has a high success rate, continues to be the preferred treatment for HCC patients with underlying chronic liver disease. ​
  • These developments demonstrate Turkey's determination to advance HCC therapy through novel research and therapies.

Hepatocellular Carcinoma (HCC) Prevention Tips

There are various ways to lower your chance of having HCC. You can do:

  • To lower your risk of developing cirrhosis, avoid drinking alcohol.
  • Maintain a healthy weight.
  • Vaccinate against hepatitis B.
  • You can lower your risk of contracting hepatitis B by getting the vaccine.
  • Take steps to prevent hepatitis C.
  • Do not use intravenous drugs,
  • When getting a piercing or tattoo, look for safe and clean shops.
  • Seek treatment for hepatitis B or C infections.

Treatment options for Hepatocellular Carcinoma (HCC)

Surgery: The surgical treatments for HCC are hepatectomy (removal of the diseased section of the liver) or liver transplantation.


Cost Start From USD 45000 - USD 60000Explore Options

Ablation therapy: This involves the use of a specialised needle to burn malignancies. The needle can direct highly hot energy (microwaves or radiofrequency waves) or extremely cold.

Embolisation: This is the process of implanting a material directly into the arteries that supply the tumour, blocking blood flow.

Radiation therapy: Providers may recommend radiation therapy to treat tiny cancers that cannot be removed surgically or destroyed through ablation.

Immunotherapy: Immunotherapy drugs are also used to treat advanced HCC. They help your immune system recognise and combat cancer cells.


Cost Start From USD 7420 - USD 42500Explore Options

Targeted therapy: These medications treat advanced HCC. This medication inhibits the signal that tells cancer cells to continue growing.


Cost Start From USD 7500 - USD 12000Explore Options

  • Blood tests: Your provider may check your blood for indicators of HCC, such as elevated alpha-fetoprotein (AFP) levels. Elevated AFP levels may indicate HCC or a disease that can develop into HCC, such as hepatitis infection or liver cirrhosis.
  • Imaging scans: Imaging treatments such as an ultrasound, computed tomography (CT) scan, magnetic resonance imaging (MRI), or angiography can detect cancers (or indicators of a tumour) within your liver.
  • Liver biopsy: Your doctor may do a liver biopsy to look for cancer cells. If your bloodwork and imaging scans do not provide enough information to make a diagnosis, you may need this test.

Hepatocellular Carcinoma (HCC) rehabilitation treatments aim to increase quality of life, accelerate physical recovery, and minimise therapeutic side effects. Here are the main rehabilitation alternatives for HCC patients:

  • Physical Rehabilitation: After liver surgery or transplant, patients may receive physical therapy to restore strength, increase flexibility, and minimise fatigue. A personalised workout regimen might help you improve your overall fitness and stamina.
  • Mobility assistance: Patients with limited movement due to treatment side effects may benefit from exercises to enhance balance and coordination.
  • Psychosocial support: Therapy or joining a support group can help cancer patients deal with the emotional and mental challenges of their treatment.

MediGence can assist and guide you in selecting the best physician and medical facility for your care.

Depending on the circumstances, your doctor may prescribe medication to assist you in managing your symptoms and support your treatment plan.

Treatment regimens are adapted to the patient's specific cancer stage and location.

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Hospitals for Hepatocellular Carcinoma (HCC) in Turkey

Medicana Camlica Hospital: Top Doctors, and Reviews
Medicana Camlica Hospital

Istanbul, Turkey

Medicana Camlica Hospital located in Istanbul, Turkey is accredited by JCI. Also listed below are some of the most prominent infrastructural details:

  • 150 bedded Hospital
  • Specialty-based clinics
  • Fully-equipped patient rooms
Memorial Sisli Hospital: Top Doctors, and Reviews
Memorial Sisli Hospital

Istanbul, Turkey

Memorial Sisli Hospital located in Istanbul, Turkey is accredited by JCI. Also listed below are some of the most prominent infrastructural details:

  • Operates in a closed area of 53,000 sqm
  • Capacity of 252 beds
  • 13 Operating rooms
  • 4 Intensive Care Units (KVC, General, Coronary, Neonatal)
  • 3 Laboratories
  • Organ Transplantation Center
  • IVF Center
  • Genetic Center
  • Stroke Center
  • Breast Health and Disease Center
  • Oncology Center
  • Da Vinci Robotic Surgery Center
  • Bone Marrow Transplantation Center
Florence Nightingale Hospital: Top Doctors, and Reviews
Florence Nightingale Hospital

Istanbul, Turkey

The first green hospital in Turkey, Istanbul Florence Nightingale Hospital, was inaugurated in 2013. Group The Florence Nightingale hospitals are the first Turkish hospitals to be granted Joint Commission International (JCI) accreditation, and they continue to be associated and work with esteemed healthcare organizations.

The Florence Nightingale Group treats 250,000 outpatients and 70,000 inpatients annually, demonstrating its excellence. The hospitals have a capacity of 804 inpatient beds, 141 ICU beds, and 40 operating rooms, and perform 20,000+ procedures annually, of which 1,000 are cardiac operations for children and 2,000 are for adults. For conducting difficult orthopedic, general surgery, minimally invasive, and other heart treatments, the facility stands out. All operating rooms can be interconnected by audio-visual to a 300-person conference room and global hubs, enabling interactive medical teaching and scientific activity.

Interpreter and translator services for languages such as Turkish, Azerbaijani, Bulgarian, Arabic, English, Persian, Serbian, Russian, Albanian, Macedonian, German, Bosnian, and Romanian are available.

The hospital has specialized departments such as Cardiology and Cardiac Surgery, IVF and Infertility, Nephrology, Oncology and Oncosurgery, Spine Surgery, Neurology and Neurosurgery, Orthopedics, Gynecology, and Obesity or Bariatric Surgery. With an extensively qualified and experienced team of advisors and interpreters, Florence Nightingale Istanbul is committed to providing one-stop service from beginning to end, 24 hours a day, 7 days a week.

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Why Choose Turkey for Hepatocellular Carcinoma (HCC) Treatment?

Here are some of the reasons for choosing Turkey:

  • World-Class Medical Expertise: Turkey has qualified oncologists and hepatologists who specialise in hepatocellular carcinoma treatment.
  • Advanced Technologies: Treatment options include radiofrequency ablation (RFA), liver transplantation, and targeted medicines that use recent medical advances.
  • Affordable Care: Compared to other nations, Turkey provides high-quality HCC treatments at a lower cost.
  • Comprehensive Patient Support: International patients receive seamless services, such as language support and specialised care, to ensure a smooth treatment experience.
  • Accredited Hospitals: Turkey's hospitals are internationally recognised, guaranteeing that patients receive high-quality care and treatment.

Frequently Asked Questions

Yes, liver transplantation is a feasible treatment option for Hepatocellular Carcinoma (HCC) in Turkey, especially for patients with early-stage cancer, liver tumors, and cirrhosis. Turkey offers several reputable transplant centers that do successful liver transplants and provide comprehensive care throughout the procedure.

Hepatocellular Carcinoma (HCC) is efficiently treated in Turkey, particularly when detected early. Turkish hospitals obtain outstanding patient results by utilizing innovative therapy.

The country's modern equipment, highly trained specialists, and extensive treatment programs all contribute to higher survival rates and better quality of life for those undergoing HCC treatment.

Survival rates for hepatocellular carcinoma (HCC) in Turkey vary depending on disease stage, liver function, and treatment strategy. According to studies, people who receive surgical therapies such as liver transplantation or hepatic resection have higher survival rates. Patients must speak with healthcare specialists to fully understand their prognosis and treatment options.

Yes, lifestyle changes include:

  • Consuming a nutritious diet rich in fruits and vegetables.
  • Exercise regularly to maintain a healthy weight.
  • Avoid alcohol and smoking.
  • Managing chronic liver illnesses such as hepatitis or fatty liver can help avoid or better manage HCC.

Compared to East Asia and Sub-Saharan Africa, Turkey has a lower incidence of hepatocellular carcinoma (HCC). The incidence rate is minimal. Chronic hepatitis B and C virus infections, which are common in Turkey, are major risk factors. Ongoing efforts to monitor and manage these risk factors are critical to reducing the incidence of HCC in Turkey.

Many patients can retain a high quality of life because of advances in therapies like surgery, liver transplants, and personalized medicines. However, the disease's impact varies depending on the cancer stage and treatment options.