Advanced diagnostic evaluation is essential for accurately determining where and how severe the obstruction is, as well as for appropriately assessing liver function and complications. Advanced vascular imaging, assessment of hepatic function, clotting studies, and interventional procedures will facilitate timely diagnosis and guide individual treatment planning. Early diagnosis of Budd-Chiari syndrome is essential to prevent the possibility of liver failure, portal hypertension, and other long-term complications. Multidisciplinary care provided by a team of highly trained hepatologists, vascular specialists, interventional radiologists, and hepatobiliary surgeons has improved both treatment efficacy and long-term patient management for Budd-Chiari syndrome.